| Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction PM Zakas, HC Brown, K Knight, SL Meeks, HT Spencer, EA Gaucher, ... Nature biotechnology 35 (1), 35-37, 2017 | 120 | 2017 |
| Target-cell-directed bioengineering approaches for gene therapy of hemophilia A HC Brown, PM Zakas, SN George, ET Parker, HT Spencer, CB Doering Molecular Therapy-Methods & Clinical Development 9, 57-69, 2018 | 53 | 2018 |
| Enhanced biosynthesis of coagulation factor VIII through diminished engagement of the unfolded protein response HC Brown, B Gangadharan, CB Doering Journal of Biological Chemistry 286 (27), 24451-24457, 2011 | 48 | 2011 |
| Effects of FVIII immunity on hepatocyte and hematopoietic stem cell–directed gene therapy of murine hemophilia A AM Lytle, HC Brown, NY Paik, KA Knight, JF Wright, HT Spencer, ... Molecular Therapy-Methods & Clinical Development 3, 2016 | 44 | 2016 |
| Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery HC Brown, JF Wright, S Zhou, AM Lytle, JE Shields, HT Spencer, ... Molecular therapy Methods & clinical development 1, 2014 | 44 | 2014 |
| Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein RJ Summers, SL Meeks, JF Healey, HC Brown, ET Parker, CL Kempton, ... Blood, The Journal of the American Society of Hematology 117 (11), 3190-3198, 2011 | 31 | 2011 |
| Development of a clinical candidate AAV3 vector for gene therapy of hemophilia B HC Brown, CB Doering, RW Herzog, C Ling, DM Markusic, HT Spencer, ... Human Gene Therapy 31 (19-20), 1114-1123, 2020 | 22 | 2020 |
| De novo and salvage purine synthesis pathways across tissues and tumors DH Tran, D Kim, R Kesavan, H Brown, T Dey, MH Soflaee, HS Vu, ... Cell, 2024 | 14 | 2024 |
| Recombinant promoters and vectors for protein expression in liver and use thereof CB Doering, HT Spencer, HC Brown US Patent 10,058,624, 2018 | 12 | 2018 |
| Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers SA Becker, BG Petrich, B Yu, KA Knight, HC Brown, SS Raikar, ... Molecular Therapy-Oncolytics 29, 145-157, 2023 | 10 | 2023 |
| Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette SRP Kumar, J Xie, S Hu, J Ko, Q Huang, HC Brown, A Srivastava, ... Molecular Therapy-Methods & Clinical Development 23, 98-107, 2021 | 10 | 2021 |
| Exploratory study of haptoglobin levels by genotype in adult sickle cell patients HC Brown, F Kutlar, B Clair, A Kutlar Blood 118 (21), 2145, 2011 | 7 | 2011 |
| Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function EL Braverman, MA McQuaid, H Schuler, M Qin, S Hani, K Hippen, ... Journal of Biological Chemistry 300 (1), 2024 | 6 | 2024 |
| Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction CW Coyle, KA Knight, HC Brown, SN George, G Denning, GM Branella, ... Journal of Thrombosis and Haemostasis 22 (3), 633-644, 2024 | 2 | 2024 |
| Ligand-based targeting of c-kit using engineered γδ T cells as a strategy for treating acute myeloid leukemia GM Branella, JY Lee, J Okalova, KK Parwani, JS Alexander, RF Arthuzo, ... Frontiers in Immunology 14, 1294555, 2023 | 2 | 2023 |
| Compositions and methods for nucleic acid transfer AG Ziady, M Siefert, S Lin, H Brown US Patent 10,894,960, 2021 | 2 | 2021 |
| Bioengineering Viral Transgenes for the Treatment of the Hemophilias HC Brown | 2 | 2016 |
| 728. Tissue-Directed Transgene Engineering for AAV and Lentivector Gene Therapy Approaches HC Brown, PM Zakas, SN George, ET Parker, HT Spencer, CB Doering Molecular Therapy 24, S287, 2016 | 2 | 2016 |
| Compositions and methods for promoting hematopoietic cell cytotoxicity HT Spencer, C Doering, S Chandrakasan, L Fleischer, J Zoine, ... US Patent App. 17/602,593, 2022 | 1 | 2022 |
| Bioengineering coagulation factor IX through ancestral sequence reconstruction K Knight, HC Brown, A Fedanov, HT Spencer, EA Gaucher, C Doering MOLECULAR THERAPY 27 (4), 276-276, 2019 | 1 | 2019 |
