Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice F Penas, GA Mirkin, M Vera, Á Cevey, CD González, MI Gómez, ME Sales, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (5), 893-904, 2015 | 134 | 2015 |
IL-10 inhibits the NF-κB and ERK/MAPK-mediated production of pro-inflammatory mediators by up-regulation of SOCS-3 in Trypanosoma cruzi-infected cardiomyocytes E Hovsepian, F Penas, S Siffo, GA Mirkin, NB Goren PloS one 8 (11), e79445, 2013 | 103 | 2013 |
IL-10/STAT3/SOCS3 axis is involved in the anti-inflammatory effect of benznidazole ÁC Cevey, FN Penas, CD Alba Soto, GA Mirkin, NB Goren Frontiers in immunology 10, 1267, 2019 | 80 | 2019 |
Modulation of inflammatory response and parasitism by 15-Deoxy-Δ12, 14 prostaglandin J2 in Trypanosoma cruzi-infected cardiomyocytes E Hovsepian, GA Mirkin, F Penas, A Manzano, R Bartrons, NB Goren International Journal for Parasitology 41 (5), 553-562, 2011 | 47 | 2011 |
Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent … ÁC Cevey, GA Mirkin, FN Penas, NB Goren International Journal for Parasitology: Drugs and Drug Resistance 6 (1), 12-22, 2016 | 46 | 2016 |
PPARγ ligand treatment inhibits cardiac inflammatory mediators induced by infection with different lethality strains of Trypanosoma cruzi F Penas, GA Mirkin, E Hovsepian, Á Cevey, R Caccuri, ME Sales, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (1), 239-248, 2013 | 38 | 2013 |
Hepatic injury associated with Trypanosoma cruzi infection is attenuated by treatment with 15-deoxy-Δ12, 14 prostaglandin J2 FN Penas, ÁC Cevey, S Siffo, GA Mirkin, NB Goren Experimental Parasitology 170, 100-108, 2016 | 31 | 2016 |
15-deoxy-Δ12, 14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome … E Hovsepian, F Penas, NB Goren Shock 34 (1), 60-67, 2010 | 31 | 2010 |
Infants younger than 6 months infected with SARS-CoV-2 show the highest respiratory viral loads V Ochoa, FE Díaz, E Ramirez, MC Fentini, M Carobene, J Geffner, ... The Journal of Infectious Diseases 225 (3), 392-395, 2022 | 24 | 2022 |
Genetic deletion of galectin-3 alters the temporal evolution of macrophage infiltration and healing affecting the cardiac remodeling and function after myocardial infarction in … P Cassaglia, F Penas, C Betazza, FF Estevez, V Miksztowicz, NM Naya, ... The American Journal of Pathology 190 (9), 1789-1800, 2020 | 23 | 2020 |
Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease ÁC Cevey, GA Mirkin, M Donato, MJ Rada, FN Penas, RJ Gelpi, ... International Journal for Parasitology: Drugs and Drug Resistance 7 (3), 378-387, 2017 | 21 | 2017 |
Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy E Hovsepian, F Penas, GA Mirkin, NB Goren PPAR research 2012 (1), 528435, 2012 | 20 | 2012 |
Pyridinecarboxylic acid derivative stimulates pro-angiogenic mediators by PI3K/AKT/mTOR and inhibits reactive nitrogen and oxygen species and NF-κB activation through a PPARγ … FN Penas, D Carta, ÁC Cevey, MJ Rada, AV Pieralisi, MG Ferlin, ... Frontiers in Immunology 10, 2955, 2020 | 18 | 2020 |
Treatment with a new peroxisome proliferator-activated receptor gamma agonist, pyridinecarboxylic acid derivative, increases angiogenesis and reduces inflammatory mediators in … FN Penas, D Carta, G Dmytrenko, GA Mirkin, CP Modenutti, ÁC Cevey, ... Frontiers in Immunology 8, 1738, 2017 | 16 | 2017 |
IL-10-dependent and-independent mechanisms are involved in the cardiac pathology modulation mediated by fenofibrate in an experimental model of chagas heart disease J Rada, M Donato, FN Penas, C Alba Soto, ÁC Cevey, AV Pieralisi, ... Frontiers in Immunology 11, 572178, 2020 | 15 | 2020 |
Benznidazole anti-inflammatory effects in murine cardiomyocytes and macrophages are mediated by class I PI3Kδ ÁC Cevey, PD Mascolo, FN Penas, AV Pieralisi, AS Sequeyra, GA Mirkin, ... Frontiers in Immunology 12, 782891, 2021 | 9 | 2021 |
Macrophages derived from septic mice modulate nitric oxide synthase and angiogenic mediators in the heart E de la Torre, E Hovsepian, FN Penas, G Dmytrenko, ME Castro, ... Journal of Cellular Physiology 228 (7), 1584-1593, 2013 | 9 | 2013 |
Genetic deletion of galectin-3 exacerbates age-related myocardial hypertrophy and fibrosis in mice FS Fontana Estevez, C Betazza, VJ Miksztowicz, IM Seropian, MG Silva, ... Karger, 2022 | 8 | 2022 |
Involvement of lipids from Leishmania braziliensis promastigotes and amastigotes in macrophage activation IE Carfagna, FN Penas, E Bott, EM Lammel, NB Goren, ML Belaunzarán, ... Molecular Immunology 125, 104-114, 2020 | 7 | 2020 |
Galectin-3 contributes to acute cardiac dysfunction and toxicity by increasing oxidative stress and fibrosis in doxorubicin-treated mice IM Seropian, FSF Estevez, A Villaverde, L Cacciagiú, R Bustos, ... International Journal of Cardiology 393, 131386, 2023 | 6 | 2023 |