Intramolecular Pd (II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope B Liégault, D Lee, MP Huestis, DR Stuart, K Fagnou The Journal of organic chemistry 73 (13), 5022-5028, 2008 | 444 | 2008 |
The Vinyl Moiety as a Handle for Regiocontrol in the Preparation of Unsymmetrical 2, 3‐Aliphatic‐Substituted Indoles and Pyrroles MP Huestis, L Chan, DR Stuart, K Fagnou Angewandte Chemie International Edition 50 (6), 1338-1341, 2011 | 368 | 2011 |
Site-Selective Azaindole Arylation at the Azine and Azole Rings via N-Oxide Activation MP Huestis, K Fagnou Organic letters 11 (6), 1357-1360, 2009 | 167 | 2009 |
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models S Patel, F Cohen, BJ Dean, K De La Torre, G Deshmukh, AA Estrada, ... Journal of medicinal chemistry 58 (1), 401-418, 2015 | 83 | 2015 |
Dual Photoredox/Nickel-Catalyzed Conversion of Aryl Halides to Aryl Aminooxetanes: Computational Evidence for a Substrate-Dependent Switch in Mechanism K Kolahdouzan, R Khalaf, JM Grandner, Y Chen, JA Terrett, MP Huestis ACS Catalysis 10, 405-411, 2019 | 37 | 2019 |
Directed Cp*RhIII-Catalyzed Fluorosulfonylvinylation of Arenes G Ncube, MP Huestis Organometallics 38 (1), 76-80, 2018 | 35 | 2018 |
Cyanide anion as a leaving group in nucleophilic aromatic substitution: synthesis of quaternary centers at azine heterocycles AD Thompson, MP Huestis The Journal of organic chemistry 78 (2), 762-769, 2013 | 35 | 2013 |
Rhodium(III)-Catalyzed C–H Functionalization of 1-(2H)-Phthalazinones at C8 MP Huestis The Journal of organic chemistry 81 (24), 12545-12552, 2016 | 34 | 2016 |
Engineering ribonucleoside triphosphate specificity in a thymidylyltransferase DL Jakeman, JL Young, MP Huestis, P Peltier, R Daniellou, ... Biochemistry 47 (33), 8719-8725, 2008 | 31 | 2008 |
Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability E Ladi, C Everett, CE Stivala, BE Daniels, MR Durk, SF Harris, MP Huestis, ... Journal of medicinal chemistry 62 (15), 7032-7041, 2019 | 30 | 2019 |
Iridium (III)‐Catalyzed Benzylic Amine Directed C H Sulfonamidation of Arenes with Sulfonyl Azides H Chen, MP Huestis ChemCatChem 7 (5), 743-746, 2015 | 27 | 2015 |
Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates MP Huestis, GA Aish, JPM Hui, EC Soo, DL Jakeman Organic & biomolecular chemistry 6 (3), 477-484, 2008 | 27 | 2008 |
Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides SA Beaton, MP Huestis, A Sadeghi-Khomami, NR Thomas, DL Jakeman Chemical Communications, 238-240, 2009 | 23 | 2009 |
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor MP Huestis, D Dela Cruz, AG DiPasquale, MR Durk, C Eigenbrot, ... Journal of Medicinal Chemistry 64 (7), 3940-3955, 2021 | 19 | 2021 |
Sequential C3 and C5 Direct C–H Arylation of Imidazo [1, 2‐a] pyrazines with (Hetero) aryl Bromides BM Johnson, MP Huestis European Journal of Organic Chemistry 2014 (8), 1589-1593, 2014 | 18 | 2014 |
Ni-Catalyzed Reductive Cross-Coupling of Cyclopropylamines and Other Strained Ring NHP Esters with (Hetero) Aryl Halides MS West, AL Gabbey, MP Huestis, SAL Rousseaux Organic Letters 24 (45), 8441-8446, 2022 | 13 | 2022 |
Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors M Volgraf, L Chan, MP Huestis, HE Purkey, M Burkard, MG Do, J Harris, ... Bioorganic & medicinal chemistry letters 24 (11), 2477-2480, 2014 | 13 | 2014 |
Substituted dipyridylamines and uses thereof F Cohen, M Huestis, C Ly, S Patel, M Siu, X Zhao US Patent 9,399,636, 2016 | 9 | 2016 |
Naphthyridines as inhibitors of HPK1 B Chan, N Rajapaksa, M Siu, C Stivala, J Tellis, W Wang, BQ Wei, A Zhou, ... US Patent 10,407,424, 2019 | 8 | 2019 |
AB3 building blocks for the synthesis of polyester dendrimers KT Jean-d’Amour, MP Huestis, TB Grindley Tetrahedron Letters 55 (23), 3436-3439, 2014 | 8 | 2014 |