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Malcolm P. Huestis
Malcolm P. Huestis
Scientist 4, Genentech, Inc.
在 gene.com 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Intramolecular Pd (II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope
B Liégault, D Lee, MP Huestis, DR Stuart, K Fagnou
The Journal of organic chemistry 73 (13), 5022-5028, 2008
4442008
The Vinyl Moiety as a Handle for Regiocontrol in the Preparation of Unsymmetrical 2, 3‐Aliphatic‐Substituted Indoles and Pyrroles
MP Huestis, L Chan, DR Stuart, K Fagnou
Angewandte Chemie International Edition 50 (6), 1338-1341, 2011
3682011
Site-Selective Azaindole Arylation at the Azine and Azole Rings via N-Oxide Activation
MP Huestis, K Fagnou
Organic letters 11 (6), 1357-1360, 2009
1672009
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models
S Patel, F Cohen, BJ Dean, K De La Torre, G Deshmukh, AA Estrada, ...
Journal of medicinal chemistry 58 (1), 401-418, 2015
832015
Dual Photoredox/Nickel-Catalyzed Conversion of Aryl Halides to Aryl Aminooxetanes: Computational Evidence for a Substrate-Dependent Switch in Mechanism
K Kolahdouzan, R Khalaf, JM Grandner, Y Chen, JA Terrett, MP Huestis
ACS Catalysis 10, 405-411, 2019
372019
Directed Cp*RhIII-Catalyzed Fluorosulfonylvinylation of Arenes
G Ncube, MP Huestis
Organometallics 38 (1), 76-80, 2018
352018
Cyanide anion as a leaving group in nucleophilic aromatic substitution: synthesis of quaternary centers at azine heterocycles
AD Thompson, MP Huestis
The Journal of organic chemistry 78 (2), 762-769, 2013
352013
Rhodium(III)-Catalyzed C–H Functionalization of 1-(2H)-Phthalazinones at C8
MP Huestis
The Journal of organic chemistry 81 (24), 12545-12552, 2016
342016
Engineering ribonucleoside triphosphate specificity in a thymidylyltransferase
DL Jakeman, JL Young, MP Huestis, P Peltier, R Daniellou, ...
Biochemistry 47 (33), 8719-8725, 2008
312008
Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability
E Ladi, C Everett, CE Stivala, BE Daniels, MR Durk, SF Harris, MP Huestis, ...
Journal of medicinal chemistry 62 (15), 7032-7041, 2019
302019
Iridium (III)‐Catalyzed Benzylic Amine Directed C H Sulfonamidation of Arenes with Sulfonyl Azides
H Chen, MP Huestis
ChemCatChem 7 (5), 743-746, 2015
272015
Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates
MP Huestis, GA Aish, JPM Hui, EC Soo, DL Jakeman
Organic & biomolecular chemistry 6 (3), 477-484, 2008
272008
Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides
SA Beaton, MP Huestis, A Sadeghi-Khomami, NR Thomas, DL Jakeman
Chemical Communications, 238-240, 2009
232009
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor
MP Huestis, D Dela Cruz, AG DiPasquale, MR Durk, C Eigenbrot, ...
Journal of Medicinal Chemistry 64 (7), 3940-3955, 2021
192021
Sequential C3 and C5 Direct C–H Arylation of Imidazo [1, 2‐a] pyrazines with (Hetero) aryl Bromides
BM Johnson, MP Huestis
European Journal of Organic Chemistry 2014 (8), 1589-1593, 2014
182014
Ni-Catalyzed Reductive Cross-Coupling of Cyclopropylamines and Other Strained Ring NHP Esters with (Hetero) Aryl Halides
MS West, AL Gabbey, MP Huestis, SAL Rousseaux
Organic Letters 24 (45), 8441-8446, 2022
132022
Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors
M Volgraf, L Chan, MP Huestis, HE Purkey, M Burkard, MG Do, J Harris, ...
Bioorganic & medicinal chemistry letters 24 (11), 2477-2480, 2014
132014
Substituted dipyridylamines and uses thereof
F Cohen, M Huestis, C Ly, S Patel, M Siu, X Zhao
US Patent 9,399,636, 2016
92016
Naphthyridines as inhibitors of HPK1
B Chan, N Rajapaksa, M Siu, C Stivala, J Tellis, W Wang, BQ Wei, A Zhou, ...
US Patent 10,407,424, 2019
82019
AB3 building blocks for the synthesis of polyester dendrimers
KT Jean-d’Amour, MP Huestis, TB Grindley
Tetrahedron Letters 55 (23), 3436-3439, 2014
82014
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