Pegylated arginine deiminase (ADI-SS PEG20, 000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo CM Ensor, FW Holtsberg, JS Bomalaski, MA Clark Cancer research 62 (19), 5443-5450, 2002 | 436 | 2002 |
Prostaglandin catabolizing enzymes HH Tai, CM Ensor, M Tong, H Zhou, F Yan Prostaglandins & other lipid mediators 68, 483-493, 2002 | 400 | 2002 |
Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation BJ Dillon, VG Prieto, SA Curley, CM Ensor, FW Holtsberg, JS Bomalaski, ... Cancer 100 (4), 826-833, 2004 | 329 | 2004 |
Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies F Izzo, P Marra, G Beneduce, G Castello, P Vallone, V De Rosa, ... Journal of clinical oncology 22 (10), 1815-1822, 2004 | 320 | 2004 |
Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies PA Ascierto, S Scala, G Castello, A Daponte, E Simeone, A Ottaiano, ... Journal of Clinical Oncology 23 (30), 7660-7668, 2005 | 293 | 2005 |
Poly (ethylene glycol)(PEG) conjugated arginine deiminase: effects of PEG formulations on its pharmacological properties FW Holtsberg, CM Ensor, MR Steiner, JS Bomalaski, MA Clark Journal of controlled release 80 (1-3), 259-271, 2002 | 195 | 2002 |
15-Hydroxyprostaglandin dehydrogenase CM Ensor, HH Tai Journal of lipid mediators and cell signalling 12 (2-3), 313-319, 1995 | 154 | 1995 |
Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. JS Bomalaski, FW Holtsberg, CM Ensor, MA Clark The Journal of rheumatology 29 (9), 1942-1949, 2002 | 146 | 2002 |
Immunohistochemical localization, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and … RK Sangha, JC Walton, CM Ensor, HH Tai, JR Challis The Journal of Clinical Endocrinology & Metabolism 78 (4), 982-989, 1994 | 145 | 1994 |
Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme CM Ensor, HH Tai Biochemical and biophysical research communications 176 (2), 840-845, 1991 | 128 | 1991 |
Cloning and sequence analysis of the cDNA for human placental NAD (+)-dependent 15-hydroxyprostaglandin dehydrogenase. CM Ensor, JY Yang, RT Okita, HH Tai Journal of Biological Chemistry 265 (25), 14888-14891, 1990 | 128 | 1990 |
A novel reagentless sensing system for measuring glucose based on the galactose/glucose-binding protein LLE Salins, RA Ware, CM Ensor, S Daunert Analytical Biochemistry 294 (1), 19-26, 2001 | 126 | 2001 |
Paper strip whole cell biosensors: a portable test for the semiquantitative detection of bacterial quorum signaling molecules A Struss, P Pasini, CM Ensor, N Raut, S Daunert Analytical chemistry 82 (11), 4457-4463, 2010 | 116 | 2010 |
Peer reviewed: Applications of reporter genes JC Lewis, A Feltus, CM Ensor, S Ramanathan, S Daunert Analytical Chemistry 70 (17), 579A-585A, 1998 | 116 | 1998 |
PEG-modified uricase CM Ensor, MA Clark, FW Holtsberg US Patent 6,913,915, 2005 | 79 | 2005 |
Biochemical characterization of the arginine degrading enzymes arginase and arginine deiminase and their effect on nitric oxide production BJ Dillon, FW Holtsberg, CM Ensor, JS Bomalaski, MA Clark Medical Science Monitor 8 (7), BR248-BR253, 2002 | 78 | 2002 |
Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase CM Ensor, HH Tai Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 1994 | 78 | 1994 |
Regression of hepatocellular cancer in a patient treated with arginine deiminase. SA Curley, JS Bomalaski, CM Ensor, FW Holtsberg, MA Clark Hepato-gastroenterology 50 (53), 1214-1216, 2003 | 63 | 2003 |
Pegylated arginine deiminase lowers hepatitis C viral titers and inhibits nitric oxide synthesis F Izzo, M Montella, AP Orlando, G Nasti, G Beneduce, G Castello, ... Journal of gastroenterology and hepatology 22 (1), 86-91, 2007 | 55 | 2007 |
Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung CM Ensor, H Zhang, HH Tai Biochemical Journal 330 (1), 103-108, 1998 | 53 | 1998 |