Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers E Lim, F Vaillant, D Wu, NC Forrest, B Pal, AH Hart, ML Asselin-Labat, ... Nature medicine 15 (8), 907-913, 2009 | 1632 | 2009 |
Association analysis identifies 65 new breast cancer risk loci K Michailidou, S Lindström, J Dennis, J Beesley, S Hui, S Kar, A Lemaçon, ... Nature 551 (7678), 92-94, 2017 | 1364 | 2017 |
Beyond GWASs: illuminating the dark road from association to function SL Edwards, J Beesley, JD French, AM Dunning The American Journal of Human Genetics 93 (5), 779-797, 2013 | 912 | 2013 |
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer SE Bojesen, KA Pooley, SE Johnatty, J Beesley, K Michailidou, JP Tyrer, ... Nature genetics 45 (4), 371-384, 2013 | 649 | 2013 |
SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer ME Askarian-Amiri, J Crawford, JD French, CE Smart, MA Smith, MB Clark, ... Rna 17 (5), 878-891, 2011 | 380 | 2011 |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer KB Kuchenbaecker, SJ Ramus, J Tyrer, A Lee, HC Shen, J Beesley, ... Nature genetics 47 (2), 164-171, 2015 | 310 | 2015 |
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers JD French, M Ghoussaini, SL Edwards, KB Meyer, K Michailidou, ... The American Journal of Human Genetics 92 (4), 489-503, 2013 | 254 | 2013 |
Point mutations in exon 1B of APC reveal gastric adenocarcinoma and proximal polyposis of the stomach as a familial adenomatous polyposis variant J Li, SL Woods, S Healey, J Beesley, X Chen, JS Lee, H Sivakumaran, ... The American Journal of Human Genetics 98 (5), 830-842, 2016 | 226 | 2016 |
Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value. CSJ Stirzaker C, Zotenko E, Song JZ, Qu W, Nair SS, Locke WJ, Stone A ... Nature Communications 6, 5899, 2015 | 219 | 2015 |
Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene SM Tan-Wong, JD French, NJ Proudfoot, MA Brown Proceedings of the National Academy of Sciences 105 (13), 5160-5165, 2008 | 172 | 2008 |
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes L Fachal, H Aschard, J Beesley, DR Barnes, J Allen, S Kar, KA Pooley, ... Nature genetics 52 (1), 56-73, 2020 | 157 | 2020 |
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 AM Dunning, K Michailidou, KB Kuchenbaecker, D Thompson, JD French, ... Nature genetics 48 (4), 374-386, 2016 | 155 | 2016 |
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1 KB Meyer, M O’Reilly, K Michailidou, S Carlebur, SL Edwards, JD French, ... The American Journal of Human Genetics 93 (6), 1046-1060, 2013 | 142 | 2013 |
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation M Ghoussaini, SL Edwards, K Michailidou, S Nord, R Cowper-Sal· lari, ... Nature communications 5 (1), 4999, 2014 | 134 | 2014 |
The expression of Ras–GTPase activating protein SH3 domain-binding proteins, G3BPs, in human breast cancers J French, R Stirling, M Walsh, H Daniel Kennedy The Histochemical journal 34, 223-231, 2002 | 120 | 2002 |
Characterization of G3BPs: Tissue specific expression, chromosomal localisation and rasGAP120 binding studies D Kennedy, J French, E Guitard, K Ru, B Tocque, J Mattick Journal of cellular biochemistry 84 (1), 173-187, 2002 | 115 | 2002 |
Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster … EJH Wee, K Peters, SS Nair, T Hulf, S Stein, S Wagner, P Bailey, SY Lee, ... Oncogene 31 (38), 4182-4195, 2012 | 100 | 2012 |
The role of noncoding variants in heritable disease JD French, SL Edwards Trends in Genetics 36 (11), 880-891, 2020 | 99 | 2020 |
Five endometrial cancer risk loci identified through genome-wide association analysis THT Cheng, DJ Thompson, TA O'Mara, JN Painter, DM Glubb, S Flach, ... Nature genetics 48 (6), 667-674, 2016 | 98 | 2016 |
Functional mechanisms underlying pleiotropic risk alleles at the 19p13. 1 breast–ovarian cancer susceptibility locus K Lawrenson, S Kar, K McCue, K Kuchenbaeker, K Michailidou, J Tyrer, ... Nature communications 7 (1), 12675, 2016 | 93 | 2016 |