Dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer V Singh, B San Yeoh, B Chassaing, X Xiao, P Saha, RA Olvera, JD Lapek, ... Cell 175 (3), 679-694. e22, 2018 | 413 | 2018 |
Essential metabolism for a minimal cell M Breuer, TM Earnest, C Merryman, KS Wise, L Sun, MR Lynott, ... Elife 8, e36842, 2019 | 148 | 2019 |
Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities JD Lapek Jr, P Greninger, R Morris, A Amzallag, I Pruteanu-Malinici, ... Nature biotechnology 35 (10), 983-989, 2017 | 142 | 2017 |
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor K Freeman-Cook, RL Hoffman, N Miller, J Almaden, J Chionis, Q Zhang, ... Cancer cell 39 (10), 1404-1421. e11, 2021 | 93 | 2021 |
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation BN Nicolay, PS Danielian, F Kottakis, JD Lapek, I Sanidas, WO Miles, ... Genes & development 29 (17), 1875-1889, 2015 | 93 | 2015 |
Functional analysis of NsrR, a nitric oxide‐sensing Rrf2 repressor in Neisseria gonorrhoeae VM Isabella, JD Lapek Jr, EM Kennedy, VL Clark Molecular microbiology 71 (1), 227-239, 2009 | 89 | 2009 |
Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models F Askarian, JD Lapek Jr, M Dongre, CM Tsai, M Kumaraswamy, A Kousha, ... Frontiers in microbiology 9, 262, 2018 | 72 | 2018 |
Quantitative temporal viromics of an inducible HIV-1 model yields insight to global host targets and phospho-dynamics associated with protein Vpr JD Lapek, MK Lewinski, JM Wozniak, J Guatelli, DJ Gonzalez Molecular & Cellular Proteomics 16 (8), 1447-1461, 2017 | 66 | 2017 |
Mitogen-and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes IK Sundar, S Chung, J Hwang, JD Lapek Jr, M Bulger, AE Friedman, ... PloS one 7 (2), e31378, 2012 | 66 | 2012 |
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer KD Freeman-Cook, RL Hoffman, DC Behenna, B Boras, J Carelli, W Diehl, ... Journal of Medicinal Chemistry 64 (13), 9056-9077, 2021 | 63 | 2021 |
Group B Streptococcus Biofilm Regulatory Protein A Contributes to Bacterial Physiology and Innate Immune Resistance KA Patras, J Derieux, MM Al-Bassam, N Adiletta, A Vrbanac, JD Lapek, ... The Journal of infectious diseases 218 (10), 1641-1652, 2018 | 51 | 2018 |
Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance L Formentini, AJ Ryan, M Gálvez-Santisteban, L Carter, P Taub, JD Lapek, ... Diabetologia 60, 2052-2065, 2017 | 47 | 2017 |
Proteomic and functional analyses of protein–DNA complexes during gene transfer MA Badding, JD Lapek, AE Friedman, DA Dean Molecular Therapy 21 (4), 775-785, 2013 | 47 | 2013 |
Reversible lysine-targeted probes reveal residence time-based kinase selectivity T Yang, A Cuesta, X Wan, GB Craven, B Hirakawa, P Khamphavong, ... Nature chemical biology 18 (9), 934-941, 2022 | 43 | 2022 |
A tyrosine switch on NEDD4-2 E3 ligase transmits GPCR inflammatory signaling NJ Grimsey, R Narala, CC Rada, S Mehta, BS Stephens, I Kufareva, ... Cell reports 24 (12), 3312-3323. e5, 2018 | 42 | 2018 |
Discovery of novel plasma biomarkers for future incident venous thromboembolism by untargeted synchronous precursor selection mass spectrometry proteomics SB Jensen, K Hindberg, T Solomon, EN Smith, JD Lapek Jr, DJ Gonzalez, ... Journal of Thrombosis and Haemostasis 16 (9), 1763-1774, 2018 | 42 | 2018 |
Cardiolipin biosynthesis in Streptococcus mutans is regulated in response to external pH ME MacGilvray, JD Lapek Jr, AE Friedman, RG Quivey Jr Microbiology 158 (8), 2133-2143, 2012 | 37 | 2012 |
Mass spectrometry detection of histidine phosphorylation on NM23-H1 JD Lapek Jr, G Tombline, AE Friedman Journal of proteome research 10 (2), 751-755, 2011 | 34 | 2011 |
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function Y Lin, JM Wozniak, NJ Grimsey, S Girada, A Patwardhan, O Molinar-Inglis, ... Proceedings of the National Academy of Sciences 117 (9), 5039-5048, 2020 | 32 | 2020 |
Quantitative multiplex substrate profiling of peptidases by mass spectrometry JD Lapek, Z Jiang, JM Wozniak, E Arutyunova, SC Wang, MJ Lemieux, ... Molecular & Cellular Proteomics 18 (5), 968a, 2019 | 32 | 2019 |