CRISPR-Cas9 knockin mice for genome editing and cancer modeling RJ Platt, S Chen, Y Zhou, MJ Yim, L Swiech, HR Kempton, JE Dahlman, ... Cell 159 (2), 440-455, 2014 | 1993 | 2014 |
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype H Yin, W Xue, S Chen, RL Bogorad, E Benedetti, M Grompe, ... Nature biotechnology 32 (6), 551-553, 2014 | 1204 | 2014 |
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells X Wu, DA Scott, AJ Kriz, AC Chiu, PD Hsu, DB Dadon, AW Cheng, ... Nature biotechnology 32 (7), 670-676, 2014 | 1160 | 2014 |
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis S Chen, NE Sanjana, K Zheng, O Shalem, K Lee, X Shi, DA Scott, J Song, ... Cell 160 (6), 1246-1260, 2015 | 1070 | 2015 |
CRISPR-mediated direct mutation of cancer genes in the mouse liver W Xue, S Chen, H Yin, T Tammela, T Papagiannakopoulos, NS Joshi, ... Nature 514 (7522), 380-384, 2014 | 880 | 2014 |
Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase K Fan, P Wei, Q Feng, S Chen, C Huang, L Ma, B Lai, J Pei, Y Liu, J Chen, ... Journal of Biological Chemistry 279 (3), 1637-1642, 2004 | 375 | 2004 |
New genes as drivers of phenotypic evolution S Chen, BH Krinsky, M Long Nature Reviews Genetics 14 (9), 645-660, 2013 | 369 | 2013 |
High-content CRISPR screening C Bock, P Datlinger, F Chardon, MA Coelho, MB Dong, KA Lawson, T Lu, ... Nature Reviews Methods Primers 2 (1), 1-23, 2022 | 319 | 2022 |
New genes in Drosophila quickly become essential S Chen, YE Zhang, M Long science 330 (6011), 1682-1685, 2010 | 305 | 2010 |
New gene evolution: little did we know M Long, NW VanKuren, S Chen, MD Vibranovski Annual review of genetics 47, 307-333, 2013 | 264 | 2013 |
Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells MB Dong, G Wang, RD Chow, L Ye, L Zhu, X Dai, JJ Park, HR Kim, ... Cell 178 (5), 1189-1204. e23, 2019 | 239 | 2019 |
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma RD Chow, CD Guzman, G Wang, F Schmidt, MW Youngblood, L Ye, ... Nature neuroscience 20 (10), 1329-1341, 2017 | 223 | 2017 |
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes NG Ravindra, MM Alfajaro, V Gasque, NC Huston, H Wan, K Szigeti-Buck, ... PLoS biology 19 (3), e3001143, 2021 | 190 | 2021 |
Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA S Yuan, L Peng, JJ Park, Y Hu, SC Devarkar, MB Dong, Q Shen, S Wu, ... Molecular cell 80 (6), 1055-1066. e6, 2020 | 164 | 2020 |
In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma L Ye, JJ Park, MB Dong, Q Yang, RD Chow, L Peng, Y Du, J Guo, X Dai, ... Nature biotechnology 37 (11), 1302-1313, 2019 | 143 | 2019 |
One-step generation of modular CAR-T cells with AAV–Cpf1 X Dai, JJ Park, Y Du, HR Kim, G Wang, Y Errami, S Chen Nature methods 16 (3), 247-254, 2019 | 140 | 2019 |
Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids DK Ma, Z Li, AY Lu, F Sun, S Chen, M Rothe, R Menzel, F Sun, HR Horvitz Cell 161 (5), 1152-1163, 2015 | 124 | 2015 |
A web tool for the design of prime-editing guide RNAs RD Chow, JS Chen, J Shen, S Chen Nature biomedical engineering 5 (2), 190-194, 2021 | 111 | 2021 |
Cancer CRISPR screens in vivo RD Chow, S Chen Trends in cancer 4 (5), 349-358, 2018 | 102 | 2018 |
Global microRNA depletion suppresses tumor angiogenesis S Chen, Y Xue, X Wu, C Le, A Bhutkar, EL Bell, F Zhang, R Langer, ... Genes & development 28 (10), 1054-1067, 2014 | 99 | 2014 |