| A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase ME Matyskiela, G Lu, T Ito, B Pagarigan, CC Lu, K Miller, W Fang, ... Nature 535 (7611), 252-257, 2016 | 543 | 2016 |
| Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs PP Chamberlain, A Lopez-Girona, K Miller, G Carmel, B Pagarigan, ... Nature structural & molecular biology 21 (9), 803-809, 2014 | 537 | 2014 |
| Structural analysis of a set of proteins resulting from a bacterial genomics project J Badger, JM Sauder, JM Adams, S Antonysamy, K Bain, MG Bergseid, ... Proteins: Structure, Function, and Bioinformatics 60 (4), 787-796, 2005 | 294 | 2005 |
| A cereblon modulator (CC-220) with improved degradation of Ikaros and Aiolos ME Matyskiela, W Zhang, HW Man, G Muller, G Khambatta, F Baculi, ... Journal of medicinal chemistry 61 (2), 535-542, 2018 | 273 | 2018 |
| Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex ME Matyskiela, T Clayton, X Zheng, C Mayne, E Tran, A Carpenter, ... Nature Structural & Molecular Biology 27 (4), 319-322, 2020 | 77 | 2020 |
| The discovery of a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor for the treatment of triple negative breast cancer initiated from a phenotypic screen JR Riggs, M Nagy, J Elsner, P Erdman, D Cashion, D Robinson, R Harris, ... Journal of medicinal chemistry 60 (21), 8989-9002, 2017 | 55 | 2017 |
| Structure of the human marker of self 5-transmembrane receptor CD47 G Fenalti, N Villanueva, M Griffith, B Pagarigan, SK Lakkaraju, ... Nature communications 12 (1), 5218, 2021 | 32 | 2021 |
| The 1.59 A resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima F Park, K Gajiwala, B Noland, L Wu, D He, J Molinari, K Loomis, ... Proteins 55 (3), 772-774, 2004 | 23 | 2004 |
| Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes P Chamberlain, S Delker, B Pagarigan, A Mahmoudi, P Jackson, ... PloS one 9 (8), e103638, 2014 | 20 | 2014 |
| Design and optimization leading to an orally active TTK protein kinase inhibitor with robust single agent efficacy JR Riggs, J Elsner, D Cashion, D Robinson, L Tehrani, M Nagy, KE Fultz, ... Journal of Medicinal Chemistry 62 (9), 4401-4410, 2019 | 16 | 2019 |
| A novel triazolopyridine-based spleen tyrosine kinase inhibitor that arrests joint inflammation GD Ferguson, M Delgado, V Plantevin-Krenitsky, K Jensen-Pergakes, ... PloS one 11 (1), e0145705, 2016 | 13 | 2016 |
| eIF4E mRNA-cap-competitive covalent inhibitors: Design, synthesis and effectiveness V Grant, D Mortensen, L Nadolny, S Norris, D Huang, J Elsner, J Parnes, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019 | | 2019 |
| Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects M Matyskiela, G Lu, T Ito, B Pagarigan, CC Lu, K Miller, W Fang, NY Wang, ... Cancer Research 77 (13_Supplement), SY37-02-SY37-02, 2017 | | 2017 |
| Potent [1, 2, 4] triazolo [1, 5-a] pyridine and 1H-pyrazolo [3, 4-d] pyrimidine inhibitors of polo-like kinase 1 and the structural basis for divergent SAR between the series P Chamberlain, SS Bahmanyar, B Pagarigan, P Patel, J Muir, D Zhu, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014 | | 2014 |
| Inhibitor Binding Mode Differences Within the AGC Subfamily S Delker, D Robinson, S Bahmanyar, B Pagarigan, W Fang, M Abbasian, ... Acta Crystallographica Section A: Foundations and Advances 70, C1640-C1640, 2014 | | 2014 |
| MiRNAs appear to target about 60% of the genes of humans and other mammals. ME Matyskiela, W Zhang, HW Man, G Muller, G Khambatta, F Baculi, ... | | |
