| Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases F Andrade, D Rafael, M Videira, D Ferreira, A Sosnik, B Sarmento Advanced drug delivery reviews 65 (13-14), 1816-1827, 2013 | 259 | 2013 |
| Stimuli-responsive hydrogels for cancer treatment: The role of pH, light, ionic strength and magnetic field F Andrade, MM Roca-Melendres, EF Durán-Lara, D Rafael, S Schwartz Jr Cancers 13 (5), 1164, 2021 | 105 | 2021 |
| Fluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cells P Gener, LP Gouveia, GR Sabat, DF de Sousa Rafael, NB Fort, A Arranja, ... Nanomedicine: Nanotechnology, Biology and Medicine 11 (8), 1883-1892, 2015 | 79 | 2015 |
| Preclinical development of siRNA therapeutics: towards the match between fundamental science and engineered systems M Videira, A Arranja, D Rafael, R Gaspar Nanomedicine: Nanotechnology, Biology and Medicine 10 (4), 689-702, 2014 | 68 | 2014 |
| Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics A Ulldemolins, J Seras-Franzoso, F Andrade, D Rafael, I Abasolo, ... Cancer Drug Resistance 4 (1), 44, 2021 | 66 | 2021 |
| Zileuton™ loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells P Gener, S Montero, H Xandri-Monje, ZV Díaz-Riascos, D Rafael, ... Nanomedicine: Nanotechnology, Biology and Medicine 24, 102106, 2020 | 53 | 2020 |
| Thermo-responsive hydrogels for cancer local therapy: Challenges and state-of-art D Rafael, MMR Melendres, F Andrade, S Montero, F Martinez-Trucharte, ... International journal of pharmaceutics 606, 120954, 2021 | 47 | 2021 |
| EMT blockage strategies: targeting Akt dependent mechanisms for breast cancer metastatic behaviour modulation D Rafael, S Doktorovova, HF Florindo, P Gener, I Abasolo, S Schwartz Jr, ... Current gene therapy 15 (3), 300-312, 2015 | 43 | 2015 |
| Polymeric micelles targeted against CD44v6 receptor increase niclosamide efficacy against colorectal cancer stem cells and reduce circulating tumor cells in vivo F Andrade, D Rafael, M Vilar-Hernandez, S Montero, ... Journal of Controlled Release 331, 198-212, 2021 | 41 | 2021 |
| AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells D Rafael, P Gener, F Andrade, J Seras-Franzoso, S Montero, ... Drug delivery 25 (1), 961-972, 2018 | 40 | 2018 |
| Pivotal role of AKT2 during dynamic phenotypic change of breast cancer stem cells P Gener, D Rafael, J Seras-Franzoso, A Perez, L Alamo Pindado, ... Cancers 11 (8), 1058, 2019 | 37 | 2019 |
| Efficient EFGR mediated siRNA delivery to breast cancer cells by Cetuximab functionalized Pluronic® F127/Gelatin D Rafael, F Martínez, F Andrade, J Seras-Franzoso, N Garcia-Aranda, ... Chemical Engineering Journal 340, 81-93, 2018 | 34 | 2018 |
| Extracellular vesicles as drug delivery systems in cancer L Hernandez-Oller, J Seras-Franzoso, F Andrade, D Rafael, I Abasolo, ... Pharmaceutics 12 (12), 1146, 2020 | 30 | 2020 |
| Sterilization procedure for temperature-sensitive hydrogels loaded with silver nanoparticles for clinical applications D Rafael, F Andrade, F Martinez-Trucharte, J Basas, J Seras-Franzoso, ... Nanomaterials 9 (3), 380, 2019 | 27 | 2019 |
| Self-assembly PEGylation assists SLN-paclitaxel delivery inducing cancer cell apoptosis upon internalization A Arranja, LF Gouveia, P Gener, DF Rafael, C Pereira, S Schwartz Jr, ... International journal of pharmaceutics 501 (1-2), 180-189, 2016 | 27 | 2016 |
| Gene therapy for advanced melanoma: selective targeting and therapeutic nucleic acids JR Viola, DF Rafael, E Wagner, R Besch, M Ogris Journal of Drug Delivery 2013 (1), 897348, 2013 | 27 | 2013 |
| Cancer stem cells and personalized cancer nanomedicine P Gener, DFS Rafael, Y Fernández, JS Ortega, D Arango, I Abasolo, ... Nanomedicine 11 (3), 307-320, 2016 | 25 | 2016 |
| Development of “on-demand” thermo-responsive hydrogels for anti-cancer drugs sustained release: Rational design, in silico prediction and in vitro validation in colon cancer models G Carreño, A Pereira, F Ávila-Salas, A Marican, F Andrade, ... Materials Science and Engineering: C 131, 112483, 2021 | 24 | 2021 |
| Lipoplexes and polyplexes: gene therapy D Rafael, F Andrade, A Arranja, S Luís, M Videira Encycl. Biomed. Polym. Polym. Biomater, 4335-4347, 2015 | 24 | 2015 |
| The biological potential hidden in inclusion bodies L Gifre-Renom, J Seras-Franzoso, D Rafael, F Andrade, O Cano-Garrido, ... Pharmaceutics 12 (2), 157, 2020 | 23 | 2020 |
