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Taka Ichu
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Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer
L Bar-Peled, EK Kemper, RM Suciu, EV Vinogradova, KM Backus, ...
Cell 171 (3), 696-709. e23, 2017
2252017
A global map of lipid-binding proteins and their ligandability in cells
MJ Niphakis, KM Lum, AB Cognetta, BE Correia, TA Ichu, J Olucha, ...
Cell 161 (7), 1668-1680, 2015
2202015
Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling
J Bi, TA Ichu, C Zanca, H Yang, W Zhang, Y Gu, S Chowdhry, A Reed, ...
Cell metabolism 30 (3), 525-538. e8, 2019
1612019
A proteome-wide atlas of lysine-reactive chemistry
ME Abbasov, ME Kavanagh, TA Ichu, MR Lazear, Y Tao, VM Crowley, ...
Nature chemistry 13 (11), 1081-1092, 2021
1312021
Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II
SWG Cheng, MA Kuzyk, A Moradian, TA Ichu, VCD Chang, JF Tien, ...
Molecular and cellular biology, 2012
1102012
LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis
A Reed, TA Ichu, N Milosevich, B Melillo, MA Schafroth, Y Otsuka, ...
ACS chemical biology 17 (6), 1607-1618, 2022
692022
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo
D Ogasawara, TA Ichu, VF Vartabedian, J Benthuysen, H Jing, A Reed, ...
Nature chemical biology 14 (12), 1099-1108, 2018
612018
Rethinking the biological relationships of the thyroid hormones, l-thyroxine and 3, 5, 3′-triiodothyronine
SK Maher, P Wojnarowicz, TA Ichu, N Veldhoen, L Lu, M Lesperance, ...
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 18 …, 2016
482016
Metabolomic insights into system-wide coordination of vertebrate metamorphosis
TA Ichu, J Han, CH Borchers, M Lesperance, CC Helbing
BMC developmental biology 14, 1-24, 2014
382014
Discovery and optimization of selective and in vivo active inhibitors of the lysophosphatidylserine lipase α/β-hydrolase domain-containing 12 (ABHD12)
D Ogasawara, TA Ichu, H Jing, JJ Hulce, A Reed, OA Ulanovskaya, ...
Journal of medicinal chemistry 62 (3), 1643-1656, 2019
342019
ABHD12 and LPCAT3 interplay regulates a lyso-phosphatidylserine-C20: 4 phosphatidylserine lipid network implicated in neurological disease
TA Ichu, A Reed, D Ogasawara, O Ulanovskaya, A Roberts, CA Aguirre, ...
Biochemistry 59 (19), 1793-1799, 2020
222020
ABHD12-LPCAT3 Interplay Regulates Immunomodulatory (Lyso) Phosphatidylserine Pathways in the Neurodegenerative Disease PHARC
TA Ichu
The Scripps Research Institute, 2020
2020
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