Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer L Bar-Peled, EK Kemper, RM Suciu, EV Vinogradova, KM Backus, ... Cell 171 (3), 696-709. e23, 2017 | 225 | 2017 |
A global map of lipid-binding proteins and their ligandability in cells MJ Niphakis, KM Lum, AB Cognetta, BE Correia, TA Ichu, J Olucha, ... Cell 161 (7), 1668-1680, 2015 | 220 | 2015 |
Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling J Bi, TA Ichu, C Zanca, H Yang, W Zhang, Y Gu, S Chowdhry, A Reed, ... Cell metabolism 30 (3), 525-538. e8, 2019 | 161 | 2019 |
A proteome-wide atlas of lysine-reactive chemistry ME Abbasov, ME Kavanagh, TA Ichu, MR Lazear, Y Tao, VM Crowley, ... Nature chemistry 13 (11), 1081-1092, 2021 | 131 | 2021 |
Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II SWG Cheng, MA Kuzyk, A Moradian, TA Ichu, VCD Chang, JF Tien, ... Molecular and cellular biology, 2012 | 110 | 2012 |
LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis A Reed, TA Ichu, N Milosevich, B Melillo, MA Schafroth, Y Otsuka, ... ACS chemical biology 17 (6), 1607-1618, 2022 | 69 | 2022 |
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo D Ogasawara, TA Ichu, VF Vartabedian, J Benthuysen, H Jing, A Reed, ... Nature chemical biology 14 (12), 1099-1108, 2018 | 61 | 2018 |
Rethinking the biological relationships of the thyroid hormones, l-thyroxine and 3, 5, 3′-triiodothyronine SK Maher, P Wojnarowicz, TA Ichu, N Veldhoen, L Lu, M Lesperance, ... Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 18 …, 2016 | 48 | 2016 |
Metabolomic insights into system-wide coordination of vertebrate metamorphosis TA Ichu, J Han, CH Borchers, M Lesperance, CC Helbing BMC developmental biology 14, 1-24, 2014 | 38 | 2014 |
Discovery and optimization of selective and in vivo active inhibitors of the lysophosphatidylserine lipase α/β-hydrolase domain-containing 12 (ABHD12) D Ogasawara, TA Ichu, H Jing, JJ Hulce, A Reed, OA Ulanovskaya, ... Journal of medicinal chemistry 62 (3), 1643-1656, 2019 | 34 | 2019 |
ABHD12 and LPCAT3 interplay regulates a lyso-phosphatidylserine-C20: 4 phosphatidylserine lipid network implicated in neurological disease TA Ichu, A Reed, D Ogasawara, O Ulanovskaya, A Roberts, CA Aguirre, ... Biochemistry 59 (19), 1793-1799, 2020 | 22 | 2020 |
ABHD12-LPCAT3 Interplay Regulates Immunomodulatory (Lyso) Phosphatidylserine Pathways in the Neurodegenerative Disease PHARC TA Ichu The Scripps Research Institute, 2020 | | 2020 |