| Acrolein disrupts tight junction proteins and causes endoplasmic reticulum stress-mediated epithelial cell death leading to intestinal barrier dysfunction and permeability WY Chen, M Wang, J Zhang, SS Barve, CJ McClain, S Joshi-Barve The American journal of pathology 187 (12), 2686-2697, 2017 | 88 | 2017 |
| Releasing addiction memories trapped in perineuronal nets AW Lasek, H Chen, WY Chen Trends in Genetics 34 (3), 197-208, 2018 | 64 | 2018 |
| Acrolein is a pathogenic mediator of alcoholic liver disease and the scavenger hydralazine is protective in mice WY Chen, J Zhang, S Ghare, S Barve, C McClain, S Joshi-Barve Cellular and molecular gastroenterology and hepatology 2 (5), 685-700, 2016 | 61 | 2016 |
| The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol … WY Chen, H Zhang, E Gatta, EJ Glover, SC Pandey, AW Lasek Alcohol 78, 79-87, 2019 | 55 | 2019 |
| Elevated fructose and uric acid through aldose reductase contribute to experimental and human alcoholic liver disease M Wang, WY Chen, J Zhang, L Gobejishvili, SS Barve, CJ McClain, ... Hepatology 72 (5), 1617-1637, 2020 | 38 | 2020 |
| Kidney Organoid and Microfluidic Kidney Chip Models to Accelerate Drug Development and Reduce Animal Testing WY Chen, EA Evangelista, J Yang, EJ Kelly, CK Yeung Frontiers in Pharmacology, 1908, 2021 | 28* | 2021 |
| Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure WY Chen, H Chen, K Hamada, E Gatta, Y Chen, H Zhang, J Drnevich, ... Translational psychiatry 11 (1), 298, 2021 | 22 | 2021 |
| Epigenetic mechanisms underlying stress-induced depression LM de Carvalho, WY Chen, AW Lasek International review of neurobiology 156, 87-126, 2021 | 21 | 2021 |
| Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients V Vatsalya, M Kong, L Gobejishvili, WY Chen, S Srivastava, S Barve, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 316 (1 …, 2019 | 19 | 2019 |
| Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine SS Ghare, H Donde, WY Chen, DF Barker, L Gobejishvilli, CJ McClain, ... Toxicology in Vitro 35, 66-76, 2016 | 8 | 2016 |
| Acrolein disrupts tight junction proteins and causes ER stress-mediated epithelial cell death leading to intestinal barrier dysfunction and permeability WY Chen, M Wang, J Zhang, SS Barve, CJ McClain, S Joshi-Barve Am J Pathol, 2017 | 5 | 2017 |
| Intestinal epithelial barrier function is disrupted by acrolein, an environmental/dietary pollutant and lipid metabolite WY Chen, J Zhang, S Barve, C McClain, S Joshi‐Barve The FASEB Journal 31, 1067.9-1067.9, 2017 | 1 | 2017 |
| Lipid‐derived aldehyde, acrolein, is a critical mediator of alcohol‐induced gut‐liver injury in alcoholic liver disease WY Chen, J Zhang, S Barve, C McClain, S Joshi‐Barve The FASEB Journal 29, 1020.8, 2015 | 1 | 2015 |
| STAT3 REGULATES NEUROIMMUNE GENE EXPRESSION IN THE RAT HIPPOCAMPUS AND DEPRESSION-LIKE BEHAVIOR DURING WITHDRAWAL FROM CHRONIC ALCOHOL DRINKING WY Chen, K Hamada, H Chen, HR Krishnan, SC Pandey, AW Lasek ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 44, 20-20, 2020 | | 2020 |
| THE HDAC INHIBITOR SAHA ALLEVIATES DEPRESSION-LIKE BEHAVIOR AND NORMALIZES HDAC2 AND ACETYLATED HISTONE H3 LEVELS IN THE HIPPOCAMPUS DURING ALCOHOL WITHDRAWAL WY Chen, H Zhang, E Gatta, H Chen, SC Pandey, AW Lasek ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 43, 144A-144A, 2019 | | 2019 |
| CHRONIC ALCOHOL DRINKING AND WITHDRAWAL INCREASES THE EXPRESSION OF THE RNA SPLICING MACHINERY IN THE RAT HIPPOCAMPUS AW Lasek, WY Chen, H Zhang, H Chen, HR Krishnan, DR Grayson, ... ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 43, 320A-320A, 2019 | | 2019 |
| ALDOSE REDUCTASE IS INVOLVED IN THE PATHOGENESIS OF ALCOHOL-ASSOCIATED LIVER DISEASE IN MICE AND PATIENTS M Wang, WY Chen, J Zhang, L Gobejishvili, S Barve, CJ McClain, ... ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 43, 42A-42A, 2019 | | 2019 |
| Aldose Reductase Is Involved in the Pathogenesis of Alcohol-Associated Liver Disease in Mice and Patients M Wang, WY Chen, L Gobejishvili, S Barve, CJ McClain, S Joshi-Barve HEPATOLOGY 68, 785A-786A, 2018 | | 2018 |
| GENOME-WIDE TRANSCRIPTIONAL CHANGES IN THE RAT HIPPOCAMPUS DURING WITHDRAWAL FROM CHRONIC ALCOHOL DRINKING IDENTIFIES ALTERED NEUROIMMUNE SIGNALING SCP Amy W Lasek, Wei-Yang Chen, Hu Chen, Ying Chen, Huaibo Zhang, Harish R ... 19th World Congress of International Society for Biomedical Research on …, 2018 | | 2018 |
| GENOME-WIDE TRANSCRIPTIONAL CHANGES IN THE RAT HIPPOCAMPUS DURING WITHDRAWAL FROM CHRONIC ALCOHOL DRINKING IDENTIFIES NEUROIMMUNE SIGNALING DISRUPTIONS WY Chen, H Chen, Y Chen, H Zhang, HR Krishnan, C Liu, DR Grayson, ... ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 42, 87A-87A, 2018 | | 2018 |
Amy W. LasekProfessor, Department of Pharmacology and Toxicology, Virginia Commonwealth University在 vcuhealth.org 的电子邮件经过验证
