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Leslie Gewin
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年份
β1 integrin expression by podocytes is required to maintain glomerular structural integrity
A Pozzi, G Jarad, GW Moeckel, S Coffa, X Zhang, L Gewin, V Eremina, ...
Developmental biology 316 (2), 288-301, 2008
2242008
Renal fibrosis: primacy of the proximal tubule
LS Gewin
Matrix Biology 68, 248-262, 2018
2022018
Progression of chronic kidney disease: too much cellular talk causes damage
L Gewin, R Zent, A Pozzi
Kidney international 91 (3), 552-560, 2017
1472017
How does TGF-β mediate tubulointerstitial fibrosis?
L Gewin, R Zent
Seminars in nephrology 32 (3), 228-235, 2012
1082012
TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration
S Chung, JM Overstreet, Y Li, Y Wang, A Niu, S Wang, X Fan, K Sasaki, ...
JCI insight 3 (21), 2018
1012018
Deleting the TGF-β receptor attenuates acute proximal tubule injury
L Gewin, S Vadivelu, S Neelisetty, MB Srichai, P Paueksakon, A Pozzi, ...
Journal of the American Society of Nephrology 23 (12), 2001-2011, 2012
902012
Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells
S Neelisetty, C Alford, K Reynolds, L Woodbury, S Nlandu-Khodo, H Yang, ...
Kidney international 88 (3), 503-514, 2015
832015
Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses
S Kishi, CR Brooks, K Taguchi, T Ichimura, Y Mori, A Akinfolarin, N Gupta, ...
The Journal of clinical investigation 129 (11), 4797-4816, 2019
812019
β1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity
X Zhang, G Mernaugh, DH Yang, L Gewin, MB Srichai, RC Harris, ...
Development 136 (19), 3357-3366, 2009
802009
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling
X Chen, H Wang, HJ Liao, W Hu, L Gewin, G Mernaugh, S Zhang, ...
The Journal of clinical investigation 124 (8), 3295-3310, 2014
782014
Sugar or fat? Renal tubular metabolism reviewed in health and disease
LS Gewin
Nutrients 13 (5), 1580, 2021
672021
Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis
JM Overstreet, Y Wang, X Wang, A Niu, LS Gewin, B Yao, RC Harris, ...
The FASEB Journal 31 (10), 4407, 2017
672017
Pharmacologic blockade of αvβ1 integrin ameliorates renal failure and fibrosis in vivo
Y Chang, WL Lau, H Jo, K Tsujino, L Gewin, NI Reed, A Atakilit, ...
Journal of the American Society of Nephrology 28 (7), 1998-2005, 2017
632017
Blocking TGF-β and β-catenin epithelial crosstalk exacerbates CKD
S Nlandu-Khodo, S Neelisetty, M Phillips, M Manolopoulou, G Bhave, ...
Journal of the American Society of Nephrology 28 (12), 3490-3503, 2017
612017
TGF-β receptor deletion in the renal collecting system exacerbates fibrosis
L Gewin, N Bulus, G Mernaugh, G Moeckel, RC Harris, HL Moses, A Pozzi, ...
Journal of the American Society of Nephrology 21 (8), 1334-1343, 2010
542010
Wnt/β-catenin in acute kidney injury and progression to chronic kidney disease
T Huffstater, WD Merryman, LS Gewin
Seminars in nephrology 40 (2), 126-137, 2020
472020
Cytometry‐based single‐cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF‐α‐induced apoptosis in vivo
AJ Simmons, A Banerjee, ET McKinley, CR Scurrah, CA Herring, ...
Molecular systems biology 11 (10), 835, 2015
462015
Transforming growth factor-β in the acute kidney injury to chronic kidney disease transition
LS Gewin
Nephron 143 (3), 154-157, 2019
422019
Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model
S Colon, H Luan, Y Liu, C Meyer, L Gewin, G Bhave
American Journal of Physiology-Renal Physiology 316 (2), F360-F371, 2019
382019
Renal tubule repair: is Wnt/β-catenin a friend or foe?
LS Gewin
Genes 9 (2), 58, 2018
312018
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