Accurate classification of BRCA1 variants with saturation genome editing GM Findlay, RM Daza, B Martin, MD Zhang, AP Leith, M Gasperini, ... Nature 562 (7726), 217-222, 2018 | 732 | 2018 |
A genome-wide framework for mapping gene regulation via cellular genetic screens M Gasperini, AJ Hill, JL McFaline-Figueroa, B Martin, S Kim, MD Zhang, ... Cell 176 (1), 377-390. e19, 2019 | 518 | 2019 |
Towards a comprehensive catalogue of validated and target-linked human enhancers M Gasperini, JM Tome, J Shendure Nature Reviews Genetics 21 (5), 292-310, 2020 | 307 | 2020 |
On the design of CRISPR-based single-cell molecular screens AJ Hill, JL McFaline-Figueroa, LM Starita, MJ Gasperini, KA Matreyek, ... Nature methods 15 (4), 271-274, 2018 | 202 | 2018 |
The power of multiplexed functional analysis of genetic variants M Gasperini, L Starita, J Shendure Nature protocols 11 (10), 1782-1787, 2016 | 161 | 2016 |
MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation MS Alexander, G Kawahara, N Motohashi, JC Casar, I Eisenberg, ... Cell Death & Differentiation 20 (9), 1194-1208, 2013 | 154 | 2013 |
CRISPR/Cas9-mediated scanning for regulatory elements required for HPRT1 expression via thousands of large, programmed genomic deletions M Gasperini, GM Findlay, A McKenna, JH Milbank, C Lee, MD Zhang, ... The American Journal of Human Genetics 101 (2), 192-205, 2017 | 147 | 2017 |
MicroRNA-486–dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy–associated symptoms MS Alexander, JC Casar, N Motohashi, NM Vieira, I Eisenberg, ... The Journal of clinical investigation 124 (6), 2651-2667, 2014 | 145 | 2014 |
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples JS Bloom, L Sathe, C Munugala, EM Jones, M Gasperini, NB Lubock, ... Nature Biomedical Engineering 5 (7), 657-665, 2021 | 59 | 2021 |
Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia C Rippey, T Walsh, S Gulsuner, M Brodsky, AS Nord, M Gasperini, ... The American Journal of Human Genetics 93 (4), 697-710, 2013 | 55 | 2013 |
Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing JS Bloom, L Sathe, C Munugala, EM Jones, M Gasperini, NB Lubock, ... MedRxiv, 2020 | 50 | 2020 |
Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling G Kawahara, MJ Gasperini, JA Myers, JJ Widrick, A Eran, PR Serafini, ... Human Molecular Genetics 23 (7), 1869-1878, 2014 | 50 | 2014 |
Identifying novel enhancer elements with CRISPR-based screens JC Klein, W Chen, M Gasperini, J Shendure ACS chemical biology 13 (2), 326-332, 2018 | 33 | 2018 |
Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A MS Alexander, MJ Gasperini, PT Tsai, DE Gibbs, JM Spinazzola, ... Translational psychiatry 6 (9), e901-e901, 2016 | 13 | 2016 |
crisprQTL mapping as a genome-wide association framework for cellular genetic screens M Gasperini, AJ Hill, JL McFaline-Figueroa, B Martin, C Trapnell, N Ahituv, ... BioRxiv, 314344, 2018 | 10 | 2018 |
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy JL McFaline-Figueroa, S Srivatsan, AJ Hill, M Gasperini, DL Jackson, ... Cell Genomics 4 (2), 2024 | 5 | 2024 |
Accurate functional classification of thousands of BRCA1 variants with saturation genome editing GM Findlay, R Daza, BK Martin, MD Zhang, AP Leith, M Gasperini, ... bioRxiv, 2019 | 5 | 2019 |
Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling G Kawahara, MJ Gasperini, JA Myers, JJ Widrick, A Eran, PR Serafini, ... Human Molecular Genetics 24 (15), 4480-4481, 2015 | 3 | 2015 |
Paired CRISPR/Cas9 guide-RNAs enable high-throughput deletion scanning (ScanDel) of a Mendelian disease locus for functionally critical non-coding elements M Gasperini, GM Findlay, A McKenna, JH Milbank, C Lee, MD Zhang, ... bioRxiv, 092445, 2016 | 2 | 2016 |
A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types Y Ben-Simon, M Hooper, S Narayan, T Daigle, D Dwivedi, SW Way, ... bioRxiv, 2024.06. 10.597244, 2024 | 1 | 2024 |