关注
Ciric To
Ciric To
Dana Farber Cancer Institute; Harvard Medical School
在 dfci.harvard.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Treatment-induced tumor dormancy through YAP-mediated transcriptional reprogramming of the apoptotic pathway
KJ Kurppa, Y Liu, C To, T Zhang, M Fan, A Vajdi, EH Knelson, Y Xie, ...
Cancer cell 37 (1), 104-122. e12, 2020
3332020
Single and dual targeting of mutant EGFR with an allosteric inhibitor
C To, J Jang, T Chen, E Park, M Mushajiang, DJH De Clercq, M Xu, ...
Cancer discovery 9 (7), 926-943, 2019
2492019
Mutant‐selective allosteric EGFR degraders are effective against a broad range of drug‐resistant mutations
J Jang, C To, DJH De Clercq, E Park, CM Ponthier, BH Shin, ...
Angewandte Chemie 132 (34), 14589-14597, 2020
952020
The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice
C To, EH Kim, DB Royce, CR Williams, RM Collins, R Risingsong, ...
Cancer Prevention Research 7 (7), 698-707, 2014
852014
EGFR-mutated lung cancers resistant to osimertinib through EGFR C797S respond to first-generation reversible EGFR inhibitors but eventually acquire EGFR T790M/C797S in …
D Rangachari, C To, JE Shpilsky, PA VanderLaan, SS Kobayashi, ...
Journal of Thoracic Oncology 14 (11), 1995-2002, 2019
772019
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer
C To, TS Beyett, J Jang, WW Feng, M Bahcall, HM Haikala, BH Shin, ...
Nature cancer 3 (4), 402-417, 2022
752022
Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung …
C To, CS Ringelberg, DB Royce, CR Williams, R Risingsong, MB Sporn, ...
Carcinogenesis 36 (7), 769-781, 2015
692015
Discovery and optimization of dibenzodiazepinones as allosteric mutant-selective EGFR inhibitors
DJH De Clercq, DE Heppner, C To, J Jang, E Park, CH Yun, ...
ACS medicinal chemistry letters 10 (11), 1549-1553, 2019
632019
Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization
C To, BH Shilton, GM Di Guglielmo
Journal of Biological Chemistry 285 (36), 27944-27957, 2010
492010
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
TS Beyett, C To, DE Heppner, JK Rana, AM Schmoker, J Jang, ...
Nature communications 13 (1), 2530, 2022
392022
The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid-imidazolide alters transforming growth factor β-dependent signaling and cell migration by affecting …
C To, S Kulkarni, T Pawson, T Honda, GW Gribble, MB Sporn, JL Wrana, ...
Journal of Biological Chemistry 283 (17), 11700-11713, 2008
362008
Discovery of a potent dual ALK and EGFR T790M inhibitor
J Jang, JB Son, C To, M Bahcall, SY Kim, SY Kang, M Mushajiang, Y Lee, ...
European journal of medicinal chemistry 136, 497-510, 2017
352017
Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019; 9 (7): 926-43. doi: 10.1158/2159-8290
C To, J Jang, T Chen, E Park, M Mushajiang, DJH De Clercq, M Xu, ...
CD-18-0903, 0
24
Design of a “two-in-one” mutant-selective epidermal growth factor receptor inhibitor that spans the orthosteric and allosteric sites
F Wittlinger, DE Heppner, C To, M Günther, BH Shin, JK Rana, ...
Journal of medicinal chemistry 65 (2), 1370-1383, 2021
182021
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer
PÖ Eser, RM Paranal, J Son, E Ivanova, Y Kuang, HM Haikala, C To, ...
Science translational medicine 13 (609), eabb3738, 2021
142021
Synthetic triterpenoids inhibit GSK3β activity and localization and affect focal adhesions and cell migration
C To, A Roy, E Chan, MAM Prado, GM Di Guglielmo
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (7), 1274-1284, 2017
132017
Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC
TW Gero, DE Heppner, TS Beyett, C To, SC Azevedo, J Jang, T Bunnell, ...
Bioorganic & medicinal chemistry letters 68, 128718, 2022
112022
Allosteric inhibition of drug resistant forms of EGFR L858R mutant NSCLC
C To, TS Beyett, J Jang, WW Feng, M Bahcall, HM Haikala, BH Shin, ...
Nature cancer 3 (4), 402, 2022
52022
PARP inhibitors for chemoprevention—Reply
C To, MB Sporn, KT Liby
Cancer Prevention Research 7 (11), 1172-1172, 2014
32014
Pharmaceutical combinations of egfr inhibitors and methods of use thereof
NS Gray, D De Clercq, J Jaebong, P Janne, C To, M Eck, P Eunyoung
US Patent App. 16/970,860, 2021
22021
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