| A mitochondrial-targeted nitroxide is a potent inhibitor of ferroptosis T Krainz, MM Gaschler, C Lim, JR Sacher, BR Stockwell, P Wipf ACS central science 2 (9), 653-659, 2016 | 220 | 2016 |
| Synthetic lethality of Wnt pathway activation and asparaginase in drug-resistant acute leukemias L Hinze, M Pfirrmann, S Karim, J Degar, C McGuckin, D Vinjamur, ... Cancer cell 35 (4), 664-676. e7, 2019 | 104 | 2019 |
| Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia FF Wagner, L Benajiba, AJ Campbell, M Weïwer, JR Sacher, JP Gale, ... Science translational medicine 10 (431), eaam8460, 2018 | 91 | 2018 |
| Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats N Escobales, RE Nuñez, S Jang, R Parodi-Rullan, S Ayala-Peña, ... Journal of molecular and cellular cardiology 77, 136-146, 2014 | 87 | 2014 |
| Inhibitors of glycogen synthase kinase 3 with exquisite kinome-wide selectivity and their functional effects FF Wagner, JA Bishop, JP Gale, X Shi, M Walk, J Ketterman, D Patnaik, ... ACS Chemical Biology 11 (7), 1952-1963, 2016 | 61 | 2016 |
| Exploiting the therapeutic interaction of WNT pathway activation and asparaginase for colorectal cancer therapy L Hinze, R Labrosse, J Degar, T Han, EM Schatoff, S Schreek, S Karim, ... Cancer discovery 10 (11), 1690-1705, 2020 | 49 | 2020 |
| Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria MC Frantz, EM Skoda, JR Sacher, MW Epperly, JP Goff, JS Greenberger, ... Organic & biomolecular chemistry 11 (25), 4147-4153, 2013 | 43 | 2013 |
| Exploratory studies toward a total synthesis of the marine ascidian metabolite perophoramidine MA Evans, JR Sacher, SM Weinreb Tetrahedron 65 (33), 6712-6719, 2009 | 40 | 2009 |
| An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility EM Skoda, JR Sacher, MZ Kazancioglu, J Saha, P Wipf ACS Medicinal Chemistry Letters 5 (8), 900-904, 2014 | 34 | 2014 |
| Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells J Ma, C Lim, JR Sacher, B Van Houten, W Qian, P Wipf Bioorganic & medicinal chemistry letters 25 (21), 4828-4833, 2015 | 33 | 2015 |
| Functionally biased D2R antagonists: targeting the β-arrestin pathway to improve antipsychotic treatment M Weïwer, Q Xu, JP Gale, M Lewis, AJ Campbell, FA Schroeder, ... ACS chemical biology 13 (4), 1038-1047, 2018 | 32 | 2018 |
| Construction of the Azocane (Azacyclooctane) Moiety of the Lycopodium Alkaloid Lycopladine H via an Intramolecular Hydroaminomethylation Strategy JR Sacher, SM Weinreb Organic letters 14 (8), 2172-2175, 2012 | 32 | 2012 |
| Virtual screening for small-molecule pathway regulators by image-profile matching MH Rohban, AM Fuller, C Tan, JT Goldstein, D Syangtan, A Gutnick, ... Cell systems 13 (9), 724-736. e9, 2022 | 30 | 2022 |
| Effectiveness of analogs of the GS-nitroxide, JP4-039, as total body irradiation mitigators MW Epperly, JR Sacher, T Krainz, X Zhang, P Wipf, M Liang, R Fisher, ... in vivo 31 (1), 39-43, 2017 | 22 | 2017 |
| Characterization of primary muscle tension dysphonia using acoustic and aerodynamic voice metrics AC Shembel, J Lee, JR Sacher, AM Johnson Journal of Voice 37 (6), 897-906, 2023 | 21 | 2023 |
| Multimodal small-molecule screening for human prion protein binders AG Reidenbach, MF Mesleh, D Casalena, SM Vallabh, JL Dahlin, ... Journal of Biological Chemistry 295 (39), 13516-13531, 2020 | 21 | 2020 |
| Synthesis of the Tetracyclic Skeleton of the Lycopodium Alkaloid Lycopladine H via a Pivotal Double Hydroformylation/Intramolecular Reductive Amination Sequence PS Chauhan, JR Sacher, SM Weinreb Organic letters 17 (4), 806-808, 2015 | 15 | 2015 |
| SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo Y Wang, C Yang, MM Sims, JR Sacher, M Raje, H Deokar, P Yue, ... Cancer Letters 533, 215614, 2022 | 14 | 2022 |
| Novel structural-related analogs of PFI-3 (SRAPs) that target the BRG1 catalytic subunit of the SWI/SNF complex increase the activity of temozolomide in glioblastoma cells Y He, C Yang, Y Wang, JR Sacher, MM Sims, LM Pfeffer, DD Miller Bioorganic & Medicinal Chemistry 53, 116533, 2022 | 8 | 2022 |
| Exploratory studies towards a total synthesis of the unusual bridged tetracyclic Lycopodium alkaloid lycopladine H JR Sacher, SM Weinreb Tetrahedron 67 (52), 10203-10207, 2011 | 8 | 2011 |
