Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1 Y Zhuang, WK Miskimins Journal of molecular signaling 3, 1-11, 2008 | 366 | 2008 |
DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine J Yu, BO Qin, AM Moyer, S Nowsheen, T Liu, S Qin, Y Zhuang, D Liu, ... The Journal of clinical investigation 128 (6), 2376-2388, 2018 | 171 | 2018 |
Mechanisms by which low glucose enhances the cytotoxicity of metformin to cancer cells both in vitro and in vivo Y Zhuang, DK Chan, AB Haugrud, WK Miskimins PloS one 9 (9), e108444, 2014 | 158 | 2014 |
Metformin induces both caspase-dependent and poly (ADP-ribose) polymerase-dependent cell death in breast cancer cells Y Zhuang, WK Miskimins Molecular Cancer Research 9 (5), 603-615, 2011 | 147 | 2011 |
Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells AB Haugrud, Y Zhuang, JD Coppock, WK Miskimins Breast cancer research and treatment 147, 539-550, 2014 | 126 | 2014 |
ERICH3: vesicular association and antidepressant treatment response D Liu, Y Zhuang, L Zhang, H Gao, D Neavin, T Carrillo-Roa, Y Wang, J Yu, ... Molecular psychiatry 26 (6), 2415-2428, 2021 | 27 | 2021 |
The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer Y Zhuang, RC Ly, CV Frazier, J Yu, S Qin, XY Fan, MP Goetz, ... Cancer & metabolism 7, 1-15, 2019 | 17 | 2019 |
NDUFA4L2 promotes trastuzumab resistance in HER2-positive breast cancer Y Yuan, H Gao, Y Zhuang, L Wei, J Yu, Z Zhang, L Zhang, L Wang Therapeutic advances in medical oncology 13, 17588359211027836, 2021 | 14 | 2021 |
Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2 TM Dudenkov, D Liu, J Cairns, S Devarajan, Y Zhuang, JN Ingle, ... Clinical Pharmacology & Therapeutics 106 (1), 219-227, 2019 | 12 | 2019 |
Identification of Src family kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer IN Kohale, J Yu, Y Zhuang, X Fan, RJ Reddy, J Sinnwell, KR Kalari, ... Cancers 14 (17), 4220, 2022 | 9 | 2022 |
Use of Antimetastatic SOD3‐Mimetic Albumin as a Primer in Triple Negative Breast Cancer SM Messerli, AM Schaefer, Y Zhuang, BJ Soltys, N Keime, J Jin, L Ma, ... Journal of Oncology 2019 (1), 3253696, 2019 | 9 | 2019 |
Biomarkers for predicting abiraterone treatment outcome and selecting alternative therapies in castration‐resistant prostate cancer S Qin, H Gao, W Kim, H Zhang, Y Gu, KR Kalari, JP Sinnwell, JA Scholz, ... Clinical Pharmacology & Therapeutics 111 (6), 1296-1306, 2022 | 8 | 2022 |
Oncolytic Urabe mumps virus: A promising virotherapy for triple-negative breast cancer MD Behrens, RJ Stiles, GM Pike, LA Sikkink, Y Zhuang, J Yu, L Wang, ... Molecular Therapy-Oncolytics 27, 239-255, 2022 | 7 | 2022 |
Establishment and characterization of immortalized human breast cancer cell lines from breast cancer patient-derived xenografts (PDX) Y Zhuang, JM Grainger, PT Vedell, J Yu, AM Moyer, H Gao, XY Fan, S Qin, ... NPJ Breast Cancer 7 (1), 79, 2021 | 7 | 2021 |
A genome-wide association study in human lymphoblastoid cells supports safety of mitochondrial complex I inhibitor H Gao, U Tripathi, S Trushin, L Okromelidze, NP Pichurin, L Wei, ... Mitochondrion 58, 83-94, 2021 | 7 | 2021 |
Preventing feedback activation of glycolytic ATP production enhances metformin cytotoxicity in breast cancer cells when oxidative phosphorylation is inhibited Y Zhuang, DK Chan, WK Miskimins Cancer & Metabolism 2, 1-2, 2014 | 2 | 2014 |
Mechanisms by Which Low Glucose Enhances the Cytotoxicity of Metformin to Cancer Cells Both Y Zhuang, DK Chan, AB Haugrud, WK Miskimins Vitro, 2014 | 2 | 2014 |
Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression Y Zhuang, AB Haugrud, MA Schaefer, SM Messerli, WK Miskimins Frontiers in Oncology 13, 1225220, 2023 | 1 | 2023 |
HPV+ cancer cell lactate production attenuates immune response during treatment: lactate production inhibition leads to improved long-term cures Y Zhuang, D Vermeer, Y Jung, A Haugrud, J Lee, WK Infectious Agents and Cancer 7 (Suppl 1), p35, 2012 | 1* | 2012 |
Metformin inhibits breast cancer cell proliferation by downregulating cyclin D1 Y Zhuang, WK Miskimins CANCER RESEARCH 66 (8), 2006 | 1 | 2006 |