Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin B Lehnertz, Y Ueda, AAHA Derijck, U Braunschweig, L Perez-Burgos, ... Current Biology 13 (14), 1192-1200, 2003 | 1501 | 2003 |
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin AHFM Peters, S Kubicek, K Mechtler, RJ O'Sullivan, AAHA Derijck, ... Molecular cell 12 (6), 1577-1589, 2003 | 1342 | 2003 |
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase S Kubicek, RJ O'Sullivan, EM August, ER Hickey, Q Zhang, ML Teodoro, ... Molecular cell 25 (3), 473-481, 2007 | 934 | 2007 |
Repression of p53 activity by Smyd2-mediated methylation J Huang, L Perez-Burgos, BJ Placek, R Sengupta, M Richter, JA Dorsey, ... Nature 444 (7119), 629-632, 2006 | 750 | 2006 |
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing S Schoeftner, AK Sengupta, S Kubicek, K Mechtler, L Spahn, H Koseki, ... The EMBO journal 25 (13), 3110-3122, 2006 | 492 | 2006 |
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse G Schotta, R Sengupta, S Kubicek, S Malin, M Kauer, E Callén, A Celeste, ... Genes & development 22 (15), 2048-2061, 2008 | 477 | 2008 |
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells BD Fodor, S Kubicek, M Yonezawa, RJ O’Sullivan, R Sengupta, ... Genes & development 20 (12), 1557-1562, 2006 | 448 | 2006 |
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres RJ O'sullivan, S Kubicek, SL Schreiber, J Karlseder Nature structural & molecular biology 17 (10), 1218-1225, 2010 | 431 | 2010 |
Artemisinins target GABAA receptor signaling and impair α cell identity J Li, T Casteels, T Frogne, C Ingvorsen, C Honore, M Courtney, ... Cell 168 (1), 86-100. e15, 2017 | 385 | 2017 |
Su (var) genes regulate the balance between euchromatin and heterochromatin in Drosophila A Ebert, G Schotta, S Lein, S Kubicek, V Krauss, T Jenuwein, G Reuter Genes & development 18 (23), 2973-2983, 2004 | 340 | 2004 |
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU (VAR) 3-3 T Rudolph, M Yonezawa, S Lein, K Heidrich, S Kubicek, C Schäfer, ... Molecular cell 26 (1), 103-115, 2007 | 306 | 2007 |
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling OA Guryanova, K Shank, B Spitzer, L Luciani, RP Koche, ... Nature medicine 22 (12), 1488-1495, 2016 | 241 | 2016 |
Single‐cell transcriptomes reveal characteristic features of human pancreatic islet cell types J Li, J Klughammer, M Farlik, T Penz, A Spittler, C Barbieux, E Berishvili, ... EMBO reports 17 (2), 178-187, 2016 | 238 | 2016 |
Rational discovery of molecular glue degraders via scalable chemical profiling C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka, M Siklos, H Imrichova, ... Nature chemical biology 16 (11), 1199-1207, 2020 | 228 | 2020 |
Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1 EM Tomazou, NC Sheffield, C Schmidl, M Schuster, A Schönegger, ... Cell reports 10 (7), 1082-1095, 2015 | 223 | 2015 |
A crack in histone lysine methylation S Kubicek, T Jenuwein Cell 119 (7), 903-906, 2004 | 199 | 2004 |
A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis A Fauster, M Rebsamen, KVM Huber, JW Bigenzahn, A Stukalov, ... Cell death & disease 6 (5), e1767-e1767, 2015 | 194 | 2015 |
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity GE Winter, B Radic, C Mayor-Ruiz, VA Blomen, C Trefzer, RK Kandasamy, ... Nature chemical biology 10 (9), 768-773, 2014 | 175 | 2014 |
Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study B Snijder, GI Vladimer, N Krall, K Miura, AS Schmolke, C Kornauth, ... The Lancet Haematology 4 (12), e595-e606, 2017 | 172 | 2017 |
A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases X Luo, Y Liu, S Kubicek, J Myllyharju, A Tumber, S Ng, KH Che, J Podoll, ... Journal of the American Chemical Society 133 (24), 9451-9456, 2011 | 170 | 2011 |