| Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate AA Chakraborty, T Laukka, M Myllykoski, AE Ringel, MA Booker, ... Science 363 (6432), 1217-1222, 2019 | 356 | 2019 |
| Transaminase inhibition by 2-hydroxyglutarate impairs glutamate biosynthesis and redox homeostasis in glioma SK McBrayer, JR Mayers, GJ DiNatale, DD Shi, J Khanal, AA Chakraborty, ... Cell 175 (1), 101-116. e25, 2018 | 302 | 2018 |
| Developmental regulation of mitochondrial apoptosis by c-Myc governs age-and tissue-specific sensitivity to cancer therapeutics KA Sarosiek, C Fraser, N Muthalagu, PD Bhola, W Chang, SK McBrayer, ... Cancer cell 31 (1), 142-156, 2017 | 242 | 2017 |
| Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy SK McBrayer, JC Cheng, S Singhal, NL Krett, ST Rosen, M Shanmugam Blood, The Journal of the American Society of Hematology 119 (20), 4686-4697, 2012 | 211 | 2012 |
| GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis DM Kremer, BS Nelson, L Lin, EL Yarosz, CJ Halbrook, SA Kerk, ... Nature communications 12 (1), 4860, 2021 | 157 | 2021 |
| Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival MG Oser, R Fonseca, AA Chakraborty, R Brough, A Spektor, RB Jennings, ... Cancer discovery 9 (2), 230-247, 2019 | 142 | 2019 |
| Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion IS Harris, JE Endress, JL Coloff, LM Selfors, SK McBrayer, JM Rosenbluth, ... Cell metabolism 29 (5), 1166-1181. e6, 2019 | 132 | 2019 |
| Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function G Notarangelo, JB Spinelli, EM Perez, GJ Baker, K Kurmi, I Elia, ... Science 377 (6614), 1519-1529, 2022 | 129 | 2022 |
| Oncogenic R132 IDH1 mutations limit NADPH for de novo lipogenesis through (D) 2-hydroxyglutarate production in fibrosarcoma cells MG Badur, T Muthusamy, SJ Parker, S Ma, SK McBrayer, T Cordes, ... Cell reports 25 (4), 1018-1026. e4, 2018 | 86 | 2018 |
| Isocitrate dehydrogenase (IDH) mutant gliomas: a Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions JJ Miller, LN Gonzalez Castro, S McBrayer, M Weller, T Cloughesy, ... Neuro-oncology 25 (1), 4-25, 2023 | 76 | 2023 |
| Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma R Bajpai, A Sharma, A Achreja, CL Edgar, C Wei, AA Siddiqa, VA Gupta, ... Nature communications 11 (1), 1228, 2020 | 76 | 2020 |
| Targeting the Warburg effect in hematological malignancies: from PET to therapy M Shanmugam, SK McBrayer, ST Rosen Current opinion in oncology 21 (6), 531-536, 2009 | 64 | 2009 |
| De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma DD Shi, MR Savani, MM Levitt, AC Wang, JE Endress, CE Bird, J Buehler, ... Cancer cell 40 (9), 939-956. e16, 2022 | 59 | 2022 |
| Molecular and metabolic mechanisms underlying selective 5-aminolevulinic acid-induced fluorescence in gliomas JI Traylor, MN Pernik, AC Sternisha, SK McBrayer, KG Abdullah Cancers 13 (3), 580, 2021 | 55 | 2021 |
| Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine M Shanmugam, SK McBrayer, J Qian, K Raikoff, MJ Avram, S Singhal, ... Journal of Biological Chemistry 284 (39), 26816-26830, 2009 | 52 | 2009 |
| Peptidic degron for IMiD-induced degradation of heterologous proteins V Koduri, SK McBrayer, E Liberzon, AC Wang, KJ Briggs, H Cho, ... Proceedings of the National Academy of Sciences 116 (7), 2539-2544, 2019 | 51 | 2019 |
| Establishment of patient-derived organoid models of lower-grade glioma KG Abdullah, CE Bird, JD Buehler, LC Gattie, MR Savani, AC Sternisha, ... Neuro-oncology 24 (4), 612-623, 2022 | 48 | 2022 |
| A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma S Pal, JP Kaplan, H Nguyen, SA Stopka, MR Savani, MS Regan, ... Cancer Cell 40 (9), 957-972. e10, 2022 | 41 | 2022 |
| Contemporary mouse models in glioma research WH Hicks, CE Bird, JI Traylor, DD Shi, TY El Ahmadieh, TE Richardson, ... Cells 10 (3), 712, 2021 | 38 | 2021 |
| HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase AA Chakraborty, E Nakamura, J Qi, A Creech, JD Jaffe, J Paulk, JS Novak, ... Science translational medicine 9 (398), eaal5272, 2017 | 37 | 2017 |
