Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes M Prabu-Jeyabalan, E Nalivaika, CA Schiffer Structure 10 (3), 369-381, 2002 | 426 | 2002 |
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor DLNG Surleraux, A Tahri, WG Verschueren, GME Pille, HA De Kock, ... Journal of medicinal chemistry 48 (6), 1813-1822, 2005 | 318 | 2005 |
Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor NM King, M Prabu-Jeyabalan, EA Nalivaika, P Wigerinck, MP de Béthune, ... Journal of virology 78 (21), 12012-12021, 2004 | 306 | 2004 |
Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments TD Wu, CA Schiffer, MJ Gonzales, J Taylor, R Kantor, S Chou, D Israelski, ... Journal of virology 77 (8), 4836-4847, 2003 | 290 | 2003 |
Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance WRP Scott, CA Schiffer Structure 8 (12), 1259-1265, 2000 | 257 | 2000 |
Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations F Muecksch, Y Weisblum, CO Barnes, F Schmidt, D Schaefer-Babajew, ... Immunity 54 (8), 1853-1868. e7, 2021 | 250 | 2021 |
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors KP Romano, A Ali, C Aydin, D Soumana, A Özen, LM Deveau, C Silver, ... PLoS pathogens 8 (7), e1002832, 2012 | 247 | 2012 |
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding KP Romano, A Ali, WE Royer, CA Schiffer Proceedings of the National Academy of Sciences 107 (49), 20986-20991, 2010 | 217 | 2010 |
How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease M Prabu-Jeyabalan, E Nalivaika, CA Schiffer Journal of molecular biology 301 (5), 1207-1220, 2000 | 217 | 2000 |
TEMP: a computational method for analyzing transposable element polymorphism in populations J Zhuang, J Wang, W Theurkauf, Z Weng Nucleic acids research 42 (11), 6826-6838, 2014 | 194* | 2014 |
Combating susceptibility to drug resistance: lessons from HIV-1 protease NM King, M Prabu-Jeyabalan, EA Nalivaika, CA Schiffer Chemistry & biology 11 (10), 1333-1338, 2004 | 185 | 2004 |
Viral protease inhibitors J Anderson, C Schiffer, SK Lee, R Swanstrom Antiviral strategies, 85-110, 2009 | 178 | 2009 |
Molecular basis for drug resistance in HIV-1 protease A Ali, RM Bandaranayake, Y Cai, NM King, M Kolli, S Mittal, JF Murzycki, ... Viruses 2 (11), 2509-2535, 2010 | 174 | 2010 |
Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A MA Carpenter, M Li, A Rathore, L Lackey, EK Law, AM Land, B Leonard, ... Journal of Biological Chemistry 287 (41), 34801-34808, 2012 | 156 | 2012 |
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces SMD Shandilya, MNL Nalam, EA Nalivaika, PJ Gross, JC Valesano, ... Structure 18 (1), 28-38, 2010 | 154 | 2010 |
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction M Ejemel, Q Li, S Hou, ZA Schiller, JA Tree, A Wallace, A Amcheslavsky, ... Nature communications 11 (1), 4198, 2020 | 150 | 2020 |
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease SC Pettit, GJ Henderson, CA Schiffer, R Swanstrom Journal of virology 76 (20), 10226-10233, 2002 | 149 | 2002 |
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site CA Schiffer, IJ Clifton, VJ Davisson, DV Santi, RM Stroud Biochemistry 34 (50), 16279-16287, 1995 | 149 | 1995 |
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity T Kouno, TV Silvas, BJ Hilbert, SMD Shandilya, MF Bohn, BA Kelch, ... Nature communications 8 (1), 15024, 2017 | 147 | 2017 |
HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants MD Altman, A Ali, GSK Kumar Reddy, MNL Nalam, SG Anjum, H Cao, ... Journal of the American Chemical Society 130 (19), 6099-6113, 2008 | 143 | 2008 |