| Targeted DNA methylation in human cells using engineered dCas9-methyltransferases T Xiong, GE Meister, RE Workman, NC Kato, MJ Spellberg, F Turker, ... Scientific reports 7 (1), 6732, 2017 | 94 | 2017 |
| Structure-guided discovery of aminoquinazolines as brain-penetrant and selective LRRK2 inhibitors MH Keylor, A Gulati, SD Kattar, RE Johnson, RW Chau, KA Margrey, ... Journal of medicinal chemistry 65 (1), 838-856, 2021 | 25 | 2021 |
| Stability of a guest protein depends on stability of a host protein in insertional fusion B Pierre, T Xiong, L Hayles, VR Guntaka, JR Kim Biotechnology and bioengineering 108 (5), 1011-1020, 2011 | 24 | 2011 |
| Molecular determinants for protein stabilization by insertional fusion to a thermophilic host protein B Pierre, JW Labonte, T Xiong, E Aoraha, A Williams, V Shah, E Chau, ... ChemBioChem 16 (16), 2392-2402, 2015 | 12 | 2015 |
| Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria T Xiong, D Rohm, RE Workman, L Roundtree, CD Novina, W Timp, ... PLoS One 13 (12), e0209408, 2018 | 11 | 2018 |
| Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease DA Candito, V Simov, A Gulati, S Kattar, RW Chau, BT Lapointe, ... Journal of Medicinal Chemistry 65 (24), 16801-16817, 2022 | 10 | 2022 |
| The interplay between effector binding and allostery in an engineered protein switch JH Choi, T Xiong, M Ostermeier Protein Science 25 (9), 1605-1616, 2016 | 7 | 2016 |
| Protein engineering strategies to improve efficiency in biomass degradation LF Ribeiro, T Xiong, P Hauk, LF Ribeiro Mycology: Current and Future Developments 1, 202-221, 2016 | 6 | 2016 |
| Protein-surfactant-polysaccharide nanoparticles increase the catalytic activity of an engineered β-lactamase maltose-activated switch enzyme JP Fuenzalida, T Xiong, BM Moerschbacher, M Ostermeier, ... bioRxiv, 746560, 2019 | 4 | 2019 |
| Discovery of MK-1468: a potent, kinome-selective, brain-penetrant amidoisoquinoline LRRK2 inhibitor for the potential treatment of Parkinson’s disease SD Kattar, A Gulati, KA Margrey, MH Keylor, M Ardolino, X Yan, ... Journal of Medicinal Chemistry 66 (21), 14912-14927, 2023 | 3 | 2023 |
| Systems and methods for genome modification and regulation C Novina, G Meister, M Ostermeier, T Xiong US Patent App. 15/539,256, 2017 | 2 | 2017 |
| Targeted Cytosine Methylation using dCas9-methyltransferases T Xiong Johns Hopkins University, 2017 | | 2017 |
| Fusion of both methyltransferase fragments to different DNA-binding domains T Xiong, C Novina, M Ostermeier Targeted Cytosine Methylation using dCas9-methyltransferases, 112, 2017 | | 2017 |
| Protein engineering strategies for improving the selective methylation of targeted CpG sites using a dCas9-directed cytosine methyltransferase T Xiong, RE Workman, D Rohm, L Roundtree, C Novina, W Timp, ... Targeted Cytosine Methylation using dCas9-methyltransferases, 81, 2017 | | 2017 |
| Supplemental Information Targeted DNA methylation in human cells using engineered dCas9-methyltransferases T Xiong, GE Meister, RE Workman, NC Kato, MJ Spellberg, F Turker, ... | | |
