Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions M Kutsch, L Sistemich, CF Lesser, MB Goldberg, C Herrmann, J Coers The EMBO journal 39 (13), e104926, 2020 | 115 | 2020 |
Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1 S Shydlovskyi, AY Zienert, S Ince, C Dovengerds, A Hohendahl, ... Proceedings of the National Academy of Sciences 114 (28), E5559-E5568, 2017 | 60 | 2017 |
Human guanylate binding proteins: nanomachines orchestrating host defense M Kutsch, J Coers The FEBS journal 288 (20), 5826-5849, 2021 | 56 | 2021 |
Dynamin‐related Irgm proteins modulate LPS‐induced caspase‐11 activation and septic shock R Finethy, J Dockterman, M Kutsch, N Orench‐Rivera, GD Wallace, ... EMBO reports 21 (11), e50830, 2020 | 45 | 2020 |
The human guanylate‐binding proteins hGBP‐1 and hGBP‐5 cycle between monomers and dimers only S Ince, M Kutsch, S Shydlovskyi, C Herrmann The FEBS Journal 284 (14), 2284-2301, 2017 | 35 | 2017 |
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction SC Walsh, JR Reitano, MS Dickinson, M Kutsch, D Hernandez, ... Cell host & microbe 30 (12), 1671-1684. e9, 2022 | 23 | 2022 |
The molecular mechanism of polymer formation of farnesylated human guanylate-binding protein 1 L Sistemich, M Kutsch, B Hämisch, P Zhang, S Shydlovskyi, ... Journal of molecular biology 432 (7), 2164-2185, 2020 | 22 | 2020 |
Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2 PS Athanasopoulos, W Jacob, S Neumann, M Kutsch, D Wolters, EK Tan, ... Biological Chemistry 397 (6), 541-554, 2016 | 21 | 2016 |
LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro MS Dickinson, M Kutsch, L Sistemich, D Hernandez, AS Piro, D Needham, ... Proceedings of the National Academy of Sciences 120 (15), e2216028120, 2023 | 20 | 2023 |
A rapidly evolving polybasic motif modulates bacterial detection by guanylate binding proteins KM Kohler, M Kutsch, AS Piro, GD Wallace, J Coers, MF Barber MBio 11 (3), 10.1128/mbio. 00340-20, 2020 | 18 | 2020 |
Structural requirements for membrane binding of human guanylate‐binding protein 1 L Sistemich, L Dimitrov Stanchev, M Kutsch, A Roux, ... The FEBS Journal 288 (13), 4098-4114, 2021 | 13 | 2021 |
Dissecting ion-specific from electrostatic salt effects on amyloid fibrillation: A case study of insulin M Kutsch, P Hortmann, C Herrmann, S Weibels, H Weingärtner Biointerphases 11 (1), 2016 | 12 | 2016 |
Catalytic activity of human guanylate‐binding protein 1 coupled to the release of structural restraints imposed by the C‐terminal domain S Ince, P Zhang, M Kutsch, O Krenczyk, S Shydlovskyi, C Herrmann The FEBS Journal 288 (2), 582-599, 2021 | 11 | 2021 |
Homo and hetero dimerisation of the human guanylate‐binding proteins hGBP‐1 and hGBP‐5 characterised by affinities and kinetics M Kutsch, S Ince, C Herrmann The FEBS Journal 285 (11), 2019-2036, 2018 | 8 | 2018 |
The GBP1 microcapsule interferes with IcsA-dependent septin cage assembly around Shigella flexneri M Kutsch, C Gonzalez-Prieto, CF Lesser, J Coers Pathogens and Disease 79 (5), ftab023, 2021 | 6 | 2021 |
GBP2 aggregates LPS and activates the caspase-4 inflammasome independent of the bacterial encapsulation factor GBP1 MS Dickinson, M Kutsch, L Sistemich, D Hernandez, AS Piro, D Needham, ... Biorxiv, 2022.10. 05.511023, 2022 | 3 | 2022 |
Kleb‘s zusammen & zerleg‘s: Detergensproteine in der zelleigenen Immunität M Kutsch BIOspektrum 30 (2), 162-164, 2024 | | 2024 |
Structural insights into the activation mechanism of antimicrobial GBP1 M Weismehl, X Chu, M Kutsch, P Lauterjung, C Herrmann, M Kudryashev, ... The EMBO Journal 43 (4), 615-636, 2024 | | 2024 |
Elucidating the activation mechanism for GBP1 oligomerization O Daumke, M Weismehl, X Chu, M Kutsch, P Lauterjung, C Herrmann, ... bioRxiv, 2023.08. 01.551421, 2023 | | 2023 |
A rapidly evolving polybasic motif modulates bacterial detection by guanylate binding proteins. mBio 11: e00340-20 KM Kohler, M Kutsch, AS Piro, GD Wallace, J Coers, MF Barber | | 2020 |