| Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity E Passini, OJ Britton, HR Lu, J Rohrbacher, AN Hermans, DJ Gallacher, ... Frontiers in physiology 8, 668, 2017 | 283 | 2017 |
| Variability in cardiac electrophysiology: using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm A Muszkiewicz, OJ Britton, P Gemmell, E Passini, C Sánchez, X Zhou, ... Progress in biophysics and molecular biology 120 (1-3), 115-127, 2016 | 180 | 2016 |
| Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block J Tomek, A Bueno-Orovio, E Passini, X Zhou, A Minchole, O Britton, ... Elife 8, e48890, 2019 | 169 | 2019 |
| Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior V András, J Tomek, N Nagy, L Virág, E Passini, B Rodriguez, I Baczkó Physiological reviews, 2021 | 142 | 2021 |
| Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy E Passini, A Mincholé, R Coppini, E Cerbai, B Rodriguez, S Severi, ... Journal of molecular and cellular cardiology 96, 72-81, 2016 | 133 | 2016 |
| General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy Z Li, GR Mirams, T Yoshinaga, BJ Ridder, X Han, JE Chen, ... Clinical Pharmacology & Therapeutics 107 (1), 102-111, 2020 | 75 | 2020 |
| Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: an in silico approach M Paci, E Passini, S Severi, J Hyttinen, B Rodriguez Heart Rhythm 14 (11), 1704-1712, 2017 | 69 | 2017 |
| All-optical electrophysiology refines populations of in silico human iPSC-CMs for drug evaluation M Paci, E Passini, A Klimas, S Severi, J Hyttinen, B Rodriguez, ... Biophysical journal 118 (10), 2596-2611, 2020 | 60 | 2020 |
| Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias E Passini, C Trovato, P Morissette, F Sannajust, A Bueno‐Orovio, ... British journal of pharmacology 176 (19), 3819-3833, 2019 | 58 | 2019 |
| Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop B Rodriguez, A Carusi, N Abi-Gerges, R Ariga, O Britton, G Bub, ... Ep Europace 18 (9), 1287-1298, 2015 | 53 | 2015 |
| Recurrent intradialytic paroxysmal atrial fibrillation: hypotheses on onset mechanisms based on clinical data and computational analysis A Vincenti, E Passini, P Fabbrini, MC Luise, S Severi, S Genovesi Europace 16 (3), 396-404, 2014 | 48 | 2014 |
| Simulation of the effects of extracellular calcium changes leads to a novel computational model of human ventricular action potential with a revised calcium handling C Bartolucci, E Passini, J Hyttinen, M Paci, S Severi Frontiers in Physiology 11, 314, 2020 | 38 | 2020 |
| Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities C Trovato, E Passini, N Nagy, A Varró, N Abi-Gerges, S Severi, ... Journal of molecular and cellular cardiology 142, 24-38, 2020 | 36 | 2020 |
| Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment X Zhou, Y Qu, E Passini, A Bueno-Orovio, Y Liu, HM Vargas, B Rodriguez Frontiers in Pharmacology 10, 1643, 2020 | 27 | 2020 |
| Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19 A Delaunois, M Abernathy, WD Anderson, KA Beattie, KW Chaudhary, ... Clinical and Translational Science 14 (3), 1133-1146, 2021 | 25 | 2021 |
| The virtual assay software for human in silico drug trials to augment drug cardiac testing E Passini, X Zhou, C Trovato, OJ Britton, A Bueno-Orovio, B Rodriguez Journal of Computational Science 52, 101202, 2021 | 19 | 2021 |
| Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions M Paci, JT Koivumäki, HR Lu, DJ Gallacher, E Passini, B Rodriguez Frontiers in Pharmacology 12, 604713, 2021 | 18 | 2021 |
| Advancing the 3Rs: innovation, implementation, ethics and society H Grimm, N Biller-Andorno, T Buch, M Dahlhoff, G Davies, CR Cederroth, ... Frontiers in Veterinary Science 10, 1185706, 2023 | 15 | 2023 |
| A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study M Paci, E Passini, S Severi, J Hyttinen, B Rodriguez 2016 Computing in Cardiology Conference (CinC), 1189-1192, 2016 | 10 | 2016 |
| In silico populations optimized on optogenetic recordings predict drug effects in human induced pluripotent stem cell-derived cardiomyocytes M Paci, E Passini, A Klimas, S Severi, J Hyttinen, B Rodriguez, ... 2018 Computing in Cardiology Conference (CinC) 45, 1-4, 2018 | 8 | 2018 |
