| Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice TP Prakash, MJ Graham, J Yu, R Carty, A Low, A Chappell, K Schmidt, ... Nucleic acids research 42 (13), 8796-8807, 2014 | 618 | 2014 |
| Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes E Koller, TM Vincent, A Chappell, S De, M Manoharan, CF Bennett Nucleic acids research 39 (11), 4795-4807, 2011 | 305 | 2011 |
| Single-stranded siRNAs activate RNAi in animals WF Lima, TP Prakash, HM Murray, GA Kinberger, W Li, AE Chappell, ... Cell 150 (5), 883-894, 2012 | 281 | 2012 |
| Pharmacokinetics of a tumor necrosis factor-α phosphorothioate 2′-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species RS Geary, ZY Rosie, T Watanabe, SP Henry, GE Hardee, A Chappell, ... Drug Metabolism and Disposition 31 (11), 1419-1428, 2003 | 188 | 2003 |
| Development of an ultrasensitive noncompetitive hybridization–ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma ZY Rosie, B Baker, A Chappell, RS Geary, E Cheung, AA Levin Analytical biochemistry 304 (1), 19-25, 2002 | 173 | 2002 |
| Comprehensive Structure–Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes TP Prakash, J Yu, MT Migawa, GA Kinberger, WB Wan, ME Østergaard, ... Journal of medicinal chemistry 59 (6), 2718-2733, 2016 | 139 | 2016 |
| Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle TP Prakash, AE Mullick, RG Lee, J Yu, ST Yeh, A Low, AE Chappell, ... Nucleic Acids Research 47 (12), 6029-6044, 2019 | 134 | 2019 |
| Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay HJ Gaus, R Gupta, AE Chappell, ME Østergaard, EE Swayze, PP Seth Nucleic acids research 47 (3), 1110-1122, 2019 | 120 | 2019 |
| Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity TP Prakash, WF Lima, HM Murray, W Li, GA Kinberger, AE Chappell, ... Nucleic acids research 43 (6), 2993-3011, 2015 | 98 | 2015 |
| TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length … S Murray, D Ittig, E Koller, A Berdeja, A Chappell, TP Prakash, M Norrbom, ... Nucleic acids research 40 (13), 6135-6143, 2012 | 92 | 2012 |
| Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA TP Prakash, GA Kinberger, HM Murray, A Chappell, S Riney, MJ Graham, ... Bioorganic & medicinal chemistry letters 26 (12), 2817-2820, 2016 | 70 | 2016 |
| Spinal distribution and metabolism of 2′-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats M Butler, CS Hayes, A Chappell, SF Murray, TL Yaksh, XY Hua Neuroscience 131 (3), 705-715, 2005 | 58 | 2005 |
| Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals TP Prakash, WF Lima, HM Murray, S Elbashir, W Cantley, D Foster, ... ACS chemical biology 8 (7), 1402-1406, 2013 | 53 | 2013 |
| Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes GA Kinberger, TP Prakash, J Yu, G Vasquez, A Low, A Chappell, ... Bioorganic & Medicinal Chemistry Letters 26 (15), 3690-3693, 2016 | 52 | 2016 |
| Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice AE Chappell, HJ Gaus, A Berdeja, R Gupta, M Jo, TP Prakash, ... Nucleic Acids Research 48 (8), 4382-4395, 2020 | 51 | 2020 |
| Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide–mediated complement activation compared with humans L Shen, A Frazer-Abel, PR Reynolds, PC Giclas, A Chappell, ... Journal of Pharmacology and Experimental Therapeutics 351 (3), 709-717, 2014 | 43 | 2014 |
| Reactions of Carbonyl-Conjugated Alkynes with N-Bromosuccinimide and N-Iodosuccinimide in DMF/H2O and Methanol/Sulfuric Acid: Syntheses of Dihalo Diketones … VL Heasley, DF Shellhamer, AE Chappell, JM Cox, DJ Hill, SL McGovern, ... The Journal of Organic Chemistry 63 (13), 4433-4437, 1998 | 38 | 1998 |
| Addition of bromine chloride and iodine monochloride to carbonyl-conjugated, acetylenic ketones: synthesis and mechanisms VL Heasley, DM Buczala, AE Chappell, DJ Hill, JM Whisenand, ... The Journal of Organic Chemistry 67 (7), 2183-2187, 2002 | 32 | 2002 |
| Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility J Floehr, E Dietzel, C Schmitz, A Chappell, W Jahnen-Dechent MHR: Basic science of reproductive medicine, 1-11, 2016 | 31 | 2016 |
| Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry TP Prakash, WB Wan, A Low, J Yu, AE Chappell, H Gaus, GA Kinberger, ... Bioorganic & medicinal chemistry letters 25 (19), 4127-4130, 2015 | 30 | 2015 |
