Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer KL Bryant, CA Stalnecker, D Zeitouni, JE Klomp, S Peng, AP Tikunov, ... Nature medicine 25 (4), 628-640, 2019 | 585 | 2019 |
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, ... Cancer discovery 10 (1), 104-123, 2020 | 163 | 2020 |
Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer H Zhang, A Schaefer, Y Wang, RG Hodge, DR Blake, JN Diehl, ... Cancer discovery 10 (2), 288-305, 2020 | 115 | 2020 |
Low-dose vertical inhibition of the RAF-MEK-ERK cascade causes apoptotic death of KRAS mutant cancers I Ozkan-Dagliyan, JN Diehl, SD George, A Schaefer, B Papke, ... Cell reports 31 (11), 2020 | 84 | 2020 |
The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma EK Lee, Z Lian, K D'Andrea, R Letrero, WQ Sheng, S Liu, JN Diehl, ... Molecular and cellular biology, 2013 | 63 | 2013 |
The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing AA Kelso, SD Goodson, LE Watts, LAL Ledford, SM Waldvogel, JN Diehl, ... Nucleic acids research 45 (2), 711-725, 2017 | 26 | 2017 |
CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment JE Klomp, YS Lee, CM Goodwin, B Papke, JA Klomp, AM Waters, ... Cell reports 37 (9), 2021 | 21 | 2021 |
Targeting p130Cas-and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition AM Waters, TO Khatib, B Papke, CM Goodwin, GA Hobbs, JN Diehl, ... Cell reports 35 (13), 2021 | 19 | 2021 |
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer JN Diehl, JE Klomp, KR Snare, PS Hibshman, DR Blake, ZD Kaiser, ... Journal of Biological Chemistry 297 (5), 2021 | 18 | 2021 |
Functional and biological heterogeneity of KRASQ61 mutations MV Huynh, GA Hobbs, A Schaefer, M Pierobon, LM Carey, JN Diehl, ... Science signaling 15 (746), eabn2694, 2022 | 17 | 2022 |
Concurrent inhibition of ERK and farnesyltransferase suppresses the growth of HRAS mutant head and neck squamous cell carcinoma S Javaid, A Schaefer, CM Goodwin, VV Nguyen, FL Massey, M Pierobon, ... Molecular cancer therapeutics 21 (5), 762-774, 2022 | 13 | 2022 |
Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer JN Diehl, PS Hibshman, I Ozkan-Dagliyan, CM Goodwin, SV Howard, ... Advances in Cancer Research 153, 101-130, 2022 | 9 | 2022 |
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation B Mucha, S Qie, S Bajpai, V Tarallo, JN Diehl, F Tedeschi, G Zhou, Z Gao, ... Nature Communications 13 (1), 6614, 2022 | 6 | 2022 |
Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer KL Bryant, CA Stalnecker, D Zeitouni, JE Klomp, S Peng, AP Tikunov, ... Nature medicine 26 (6), 982-982, 2020 | 6 | 2020 |
A standardized method for plasma extracellular vesicle isolation and size distribution analysis JN Diehl, A Ray, LB Collins, A Peterson, KC Alexander, JG Boutros, ... Plos one 18 (4), e0284875, 2023 | 5 | 2023 |
Long-term outcomes of robotic versus video-assisted pulmonary lobectomy for non-small cell lung cancer: systematic review and meta-analysis of reconstructed patient data PT Tasoudis, JN Diehl, A Merlo, JM Long Journal of Thoracic Disease 15 (10), 5700, 2023 | 4 | 2023 |
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer JE Klomp, JN Diehl, JA Klomp, AC Edwards, R Yang, AJ Morales, ... Science 384 (6700), eadk0850, 2024 | 3 | 2024 |
Defining the KRAS-and ERK-dependent transcriptome in KRAS-mutant cancers JA Klomp, JE Klomp, CA Stalnecker, KL Bryant, AC Edwards, ... Science 384 (6700), eadk0775, 2024 | 3 | 2024 |
RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling A Schaefer, RG Hodge, H Zhang, GA Hobbs, J Dilly, MV Huynh, ... Science signaling 16 (816), eadg5289, 2023 | 1 | 2023 |
RAS: Past, Present, and Future JP O'Bryan, G Piazza Academic Press, 2022 | 1 | 2022 |