关注
J. Nathaniel Diehl
J. Nathaniel Diehl
其他姓名J. Nate Diehl
Surgery Resident, Hosp. of Univ. of Pennsylvania
在 pennmedicine.upenn.edu 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
KL Bryant, CA Stalnecker, D Zeitouni, JE Klomp, S Peng, AP Tikunov, ...
Nature medicine 25 (4), 628-640, 2019
5852019
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, ...
Cancer discovery 10 (1), 104-123, 2020
1632020
Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer
H Zhang, A Schaefer, Y Wang, RG Hodge, DR Blake, JN Diehl, ...
Cancer discovery 10 (2), 288-305, 2020
1152020
Low-dose vertical inhibition of the RAF-MEK-ERK cascade causes apoptotic death of KRAS mutant cancers
I Ozkan-Dagliyan, JN Diehl, SD George, A Schaefer, B Papke, ...
Cell reports 31 (11), 2020
842020
The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma
EK Lee, Z Lian, K D'Andrea, R Letrero, WQ Sheng, S Liu, JN Diehl, ...
Molecular and cellular biology, 2013
632013
The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing
AA Kelso, SD Goodson, LE Watts, LAL Ledford, SM Waldvogel, JN Diehl, ...
Nucleic acids research 45 (2), 711-725, 2017
262017
CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
JE Klomp, YS Lee, CM Goodwin, B Papke, JA Klomp, AM Waters, ...
Cell reports 37 (9), 2021
212021
Targeting p130Cas-and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
AM Waters, TO Khatib, B Papke, CM Goodwin, GA Hobbs, JN Diehl, ...
Cell reports 35 (13), 2021
192021
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer
JN Diehl, JE Klomp, KR Snare, PS Hibshman, DR Blake, ZD Kaiser, ...
Journal of Biological Chemistry 297 (5), 2021
182021
Functional and biological heterogeneity of KRASQ61 mutations
MV Huynh, GA Hobbs, A Schaefer, M Pierobon, LM Carey, JN Diehl, ...
Science signaling 15 (746), eabn2694, 2022
172022
Concurrent inhibition of ERK and farnesyltransferase suppresses the growth of HRAS mutant head and neck squamous cell carcinoma
S Javaid, A Schaefer, CM Goodwin, VV Nguyen, FL Massey, M Pierobon, ...
Molecular cancer therapeutics 21 (5), 762-774, 2022
132022
Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer
JN Diehl, PS Hibshman, I Ozkan-Dagliyan, CM Goodwin, SV Howard, ...
Advances in Cancer Research 153, 101-130, 2022
92022
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation
B Mucha, S Qie, S Bajpai, V Tarallo, JN Diehl, F Tedeschi, G Zhou, Z Gao, ...
Nature Communications 13 (1), 6614, 2022
62022
Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
KL Bryant, CA Stalnecker, D Zeitouni, JE Klomp, S Peng, AP Tikunov, ...
Nature medicine 26 (6), 982-982, 2020
62020
A standardized method for plasma extracellular vesicle isolation and size distribution analysis
JN Diehl, A Ray, LB Collins, A Peterson, KC Alexander, JG Boutros, ...
Plos one 18 (4), e0284875, 2023
52023
Long-term outcomes of robotic versus video-assisted pulmonary lobectomy for non-small cell lung cancer: systematic review and meta-analysis of reconstructed patient data
PT Tasoudis, JN Diehl, A Merlo, JM Long
Journal of Thoracic Disease 15 (10), 5700, 2023
42023
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
JE Klomp, JN Diehl, JA Klomp, AC Edwards, R Yang, AJ Morales, ...
Science 384 (6700), eadk0850, 2024
32024
Defining the KRAS-and ERK-dependent transcriptome in KRAS-mutant cancers
JA Klomp, JE Klomp, CA Stalnecker, KL Bryant, AC Edwards, ...
Science 384 (6700), eadk0775, 2024
32024
RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
A Schaefer, RG Hodge, H Zhang, GA Hobbs, J Dilly, MV Huynh, ...
Science signaling 16 (816), eadg5289, 2023
12023
RAS: Past, Present, and Future
JP O'Bryan, G Piazza
Academic Press, 2022
12022
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