| High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources RA Haraszti, MC Didiot, E Sapp, J Leszyk, SA Shaffer, HE Rockwell, ... Journal of extracellular vesicles 5 (1), 32570, 2016 | 640 | 2016 |
| Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing MC Didiot, LM Hall, AH Coles, RA Haraszti, BMDC Godinho, K Chase, ... Molecular Therapy 24 (10), 1836-1847, 2016 | 458 | 2016 |
| Exosomes produced from 3D cultures of MSCs by tangential flow filtration show higher yield and improved activity RA Haraszti, R Miller, M Stoppato, YY Sere, A Coles, MC Didiot, ... Molecular Therapy 26 (12), 2838-2847, 2018 | 374 | 2018 |
| A novel function for fragile X mental retardation protein in translational activation EG Bechara, MC Didiot, M Melko, L Davidovic, M Bensaid, P Martin, ... PLoS biology 7 (1), e1000016, 2009 | 249 | 2009 |
| The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer MC Didiot, Z Tian, C Schaeffer, M Subramanian, JL Mandel, H Moine Nucleic acids research 36 (15), 4902-4912, 2008 | 208 | 2008 |
| Hydrophobically modified siRNAs silence huntingtin mRNA in primary neurons and mouse brain JF Alterman, LM Hall, AH Coles, MR Hassler, MC Didiot, K Chase, ... Molecular Therapy-Nucleic Acids 4, 2015 | 152 | 2015 |
| Cells lacking the fragile X mental retardation protein (FMRP) have normal RISC activity but exhibit altered stress granule assembly MC Didiot, M Subramanian, E Flatter, JL Mandel, H Moine Molecular biology of the cell 20 (1), 428-437, 2009 | 125 | 2009 |
| Visualization of self-delivering hydrophobically modified siRNA cellular internalization S Ly, DM Navaroli, MC Didiot, J Cardia, L Pandarinathan, JF Alterman, ... Nucleic acids research 45 (1), 15-25, 2017 | 98 | 2017 |
| Optimized cholesterol-siRNA chemistry improves productive loading onto extracellular vesicles RA Haraszti, R Miller, MC Didiot, A Biscans, JF Alterman, MR Hassler, ... Molecular Therapy 26 (8), 1973-1982, 2018 | 86 | 2018 |
| Serum deprivation of mesenchymal stem cells improves exosome activity and alters lipid and protein composition RA Haraszti, R Miller, ML Dubuke, HE Rockwell, AH Coles, E Sapp, ... Iscience 16, 230-241, 2019 | 74 | 2019 |
| Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs MF Osborn, JF Alterman, M Nikan, H Cao, MC Didiot, MR Hassler, ... Nucleic acids research 43 (18), 8664-8672, 2015 | 50 | 2015 |
| Nuclear localization of huntingtin mRNA is specific to cells of neuronal origin MC Didiot, CM Ferguson, S Ly, AH Coles, AO Smith, AA Bicknell, LM Hall, ... Cell reports 24 (10), 2553-2560. e5, 2018 | 48 | 2018 |
| Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles A Biscans, RA Haraszti, D Echeverria, R Miller, MC Didiot, M Nikan, ... Molecular Therapy 26 (6), 1520-1528, 2018 | 40 | 2018 |
| Identification of cardiac glycoside molecules as inhibitors of c-Myc IRES-mediated translation MC Didiot, J Hewett, T Varin, F Freuler, D Selinger, H Nick, J Reinhardt, ... Journal of biomolecular screening 18 (4), 407-419, 2013 | 29 | 2013 |
| Multiplexed reporter gene assays: monitoring the cell viability and the compound kinetics on luciferase activity MC Didiot, S Serafini, MJ Pfeifer, FJ King, CN Parker Journal of biomolecular screening 16 (7), 786-793, 2011 | 21 | 2011 |
| Latent hit series hidden in high-throughput screening data T Varin, MC Didiot, CN Parker, A Schuffenhauer Journal of medicinal chemistry 55 (3), 1161-1170, 2012 | 19 | 2012 |
| Loading of extracellular vesicles with hydrophobically modified siRNAs MC Didiot, RA Haraszti, N Aronin, A Khvorova Extracellular RNA: Methods and Protocols, 199-214, 2018 | 18 | 2018 |
| Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains S Ly, MC Didiot, CM Ferguson, AH Coles, R Miller, K Chase, D Echeverria, ... Brain Communications 4 (6), fcac248, 2022 | 10 | 2022 |
| A high-throughput assay for mRNA silencing in primary cortical neurons in vitro with oligonucleotide therapeutics JF Alterman, AH Coles, LM Hall, N Aronin, A Khvorova, MC Didiot Bio-protocol 7 (16), e2501-e2501, 2017 | 10 | 2017 |
| Loading of extracellular vesicles with chemically stabilized hydrophobic siRNAs for the treatment of disease in the central nervous system RA Haraszti, A Coles, N Aronin, A Khvorova, MC Didiot Bio-protocol 7 (12), e2338-e2338, 2017 | 10 | 2017 |
