Function-oriented synthesis, step economy, and drug design PA Wender, VA Verma, TJ Paxton, TH Pillow Accounts of chemical research 41 (1), 40-49, 2008 | 1248 | 2008 |
Structural basis for dual-mode inhibition of the ABC transporter MsbA H Ho, A Miu, MK Alexander, NK Garcia, A Oh, I Zilberleyb, M Reichelt, ... Nature 557 (7704), 196-201, 2018 | 164 | 2018 |
Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity PA Wender, JL Baryza, SE Brenner, BA DeChristopher, BA Loy, ... Proceedings of the National Academy of Sciences 108 (17), 6721-6726, 2011 | 122 | 2011 |
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2 … JA Menendez, I Mehmi, VA Verma, PK Teng, R Lupu Molecular Carcinogenesis: Published in cooperation with the University of …, 2004 | 107 | 2004 |
Actin is the primary cellular receptor of bistramide A AV Statsuk, R Bai, JL Baryza, VA Verma, E Hamel, PA Wender, ... Nature Chemical Biology 1 (7), 383-388, 2005 | 101 | 2005 |
Discovery of peptidomimetic antibody–drug conjugate linkers with enhanced protease specificity BQ Wei, J Gunzner-Toste, H Yao, T Wang, J Wang, Z Xu, J Chen, J Wai, ... Journal of medicinal chemistry 61 (3), 989-1000, 2018 | 94 | 2018 |
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment A Balestrini, V Joseph, M Dourado, RM Reese, SD Shields, L Rougé, ... Journal of Experimental Medicine 218 (4), 2021 | 86 | 2021 |
A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts TK Khan, TJ Nelson, VA Verma, PA Wender, DL Alkon Neurobiology of disease 34 (2), 332-339, 2009 | 84 | 2009 |
The cryptophycins as potent payloads for antibody drug conjugates VA Verma, TH Pillow, L DePalatis, G Li, GL Phillips, AG Polson, HE Raab, ... Bioorganic & medicinal chemistry letters 25 (4), 864-868, 2015 | 69 | 2015 |
Disrupting gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA MK Alexander, A Miu, A Oh, M Reichelt, H Ho, C Chalouni, S Labadie, ... Antimicrobial Agents and Chemotherapy 62 (11), 10.1128/aac. 01142-18, 2018 | 67 | 2018 |
2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases V Girijavallabhan, FG Njoroge, S Bogen, F Bennett, V Verma, ... US Patent 9,156,872, 2015 | 67 | 2015 |
The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity PA Wender, VA Verma Organic letters 10 (15), 3331-3334, 2008 | 65 | 2008 |
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol-and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial … JA Menendez, BP Oza, E Atlas, VA Verma, I Mehmi, R Lupu Oncogene 23 (28), 4945-4958, 2004 | 62 | 2004 |
2′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases V Girijavallabhan, FG Njoroge, S Bogen, V Verma, F Bennett, A Kerekes, ... US Patent 9,061,041, 2015 | 59 | 2015 |
Total synthesis and initial biological evaluation of new B-ring-modified bryostatin analogs PA Wender, JC Horan, VA Verma Organic Letters 8 (23), 5299-5302, 2006 | 52 | 2006 |
Curse or cure? A perspective on the developability of aldehydes as active pharmaceutical ingredients C Gampe, VA Verma Journal of Medicinal Chemistry 63 (23), 14357-14381, 2020 | 47 | 2020 |
Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin PA Wender, VA Verma Organic Letters 8 (9), 1893-1896, 2006 | 43 | 2006 |
Substituted pyridine and pyrimidine derivatives and their use in treating viral infections A Arasappan, FG Njoroge, CD Kwong, S Ananthan, F Bennett, J Clark, ... US Patent 8,697,694, 2014 | 42 | 2014 |
Discovery of a Potent (4R,5S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug … H Chen, M Volgraf, S Do, A Kolesnikov, DG Shore, VA Verma, E Villemure, ... Journal of Medicinal Chemistry 61 (8), 3641-3659, 2018 | 41 | 2018 |
Peptidomimetic compounds and antibody-drug conjugates thereof J Flygare, J Gunzner-Toste, T Pillow, B Safina, V Verma, BQ Wei, G Zhao, ... US Patent 10,533,058, 2020 | 32 | 2020 |