| TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species C Chen, Y Liu, R Liu, T Ikenoue, KL Guan, Y Liu, P Zheng The Journal of experimental medicine 205 (10), 2397-2408, 2008 | 763 | 2008 |
| mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells C Chen, Y Liu, Y Liu, P Zheng Science signaling 2 (98), ra75-ra75, 2009 | 715 | 2009 |
| MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia C Chen, Y Liu, AR Rappaport, T Kitzing, N Schultz, Z Zhao, AS Shroff, ... Cancer cell 25 (5), 652-665, 2014 | 343 | 2014 |
| Deletions linked to TP53 loss drive cancer through p53-independent mechanisms Y Liu, C Chen, Z Xu, C Scuoppo, CD Rillahan, J Gao, B Spitzer, ... Nature 531 (7595), 471-475, 2016 | 264 | 2016 |
| Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition C Chen, Y Liu, C Lu, JR Cross, JP Morris, AS Shroff, PS Ward, JE Bradner, ... Genes & development 27 (18), 1974-1985, 2013 | 217 | 2013 |
| Heat shock response relieves ER stress Y Liu, A Chang The EMBO journal 27 (7), 1049-1059, 2008 | 199 | 2008 |
| Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice C Chen, Y Liu, Y Liu, P Zheng The Journal of clinical investigation 120 (11), 4091-4101, 2010 | 123 | 2010 |
| An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose-and amino acid-deprivation P Ye, Y Liu, C Chen, F Tang, Q Wu, X Wang, CG Liu, X Liu, R Liu, Y Liu, ... Molecular cell 57 (4), 708-720, 2015 | 100 | 2015 |
| Nivolumab treatment of relapsed/refractory Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in adults P Liu, X Pan, C Chen, T Niu, X Shuai, J Wang, X Chen, J Liu, Y Guo, L Xie, ... Blood, The Journal of the American Society of Hematology 135 (11), 826-833, 2020 | 99 | 2020 |
| The tuberous sclerosis complex–mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells Q Wu, Y Liu, C Chen, T Ikenoue, Y Qiao, CS Li, W Li, KL Guan, Y Liu, ... The Journal of Immunology 187 (3), 1106-1112, 2011 | 90 | 2011 |
| Cytoplasmic Hsp70 promotes ubiquitination for endoplasmic reticulum-associated degradation of a misfolded mutant of the yeast plasma membrane ATPase, PMA1 S Han, Y Liu, A Chang Journal of Biological Chemistry 282 (36), 26140-26149, 2007 | 85 | 2007 |
| Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis C Yin, B Zhu, T Zhang, T Liu, S Chen, Y Liu, X Li, X Miao, S Li, X Mi, ... Cell 176 (5), 1113-1127. e16, 2019 | 76 | 2019 |
| The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells C Chen, Y Liu, Y Liu, P Zheng Cell cycle 8 (8), 1158-1160, 2009 | 70 | 2009 |
| Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma X Wang, R Zhou, Y Xiong, L Zhou, X Yan, M Wang, F Li, C Xie, Y Zhang, ... Cell research 31 (6), 684-702, 2021 | 57 | 2021 |
| KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming F Na, X Pan, J Chen, X Chen, M Wang, P Chi, L You, L Zhang, A Zhong, ... Nature cancer 3 (6), 753-767, 2022 | 51 | 2022 |
| Quality control of a mutant plasma membrane ATPase: ubiquitylation prevents cell-surface stability Y Liu, A Chang Journal of cell science 119 (2), 360-369, 2006 | 33 | 2006 |
| SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis P Tan, M Wang, A Zhong, Y Wang, J Du, J Wang, L Qi, Z Bi, P Zhang, ... Oncogene 40 (42), 6081-6092, 2021 | 32 | 2021 |
| Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer M Wang, X Chen, P Tan, Y Wang, X Pan, T Lin, Y Jiang, B Wang, H Xu, ... Cancer Cell 40 (9), 1044-1059. e8, 2022 | 27 | 2022 |
| Multiple degradation pathways for misfolded mutants of the yeast plasma membrane ATPase, Pma1 Y Liu, S Sitaraman, A Chang Journal of Biological Chemistry 281 (42), 31457-31466, 2006 | 27 | 2006 |
| Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis Q Zhang, L Zhao, Y Yang, S Li, Y Liu, C Chen JCI insight 7 (3), 2022 | 24 | 2022 |
