| What makes a good protein–protein interaction stabilizer: Analysis and application of the dual-binding mechanism SY Chen, M Zacharias ACS central science 9 (5), 969-979, 2023 | 15 | 2023 |
| How mutations perturb γ-secretase active site studied by free energy simulations SY Chen, M Zacharias ACS Chemical Neuroscience 11 (20), 3321-3332, 2020 | 14 | 2020 |
| An internal docking site stabilizes substrate binding to γ-secretase: Analysis by molecular dynamics simulations SY Chen, M Zacharias Biophysical Journal 121 (12), 2330-2344, 2022 | 10 | 2022 |
| APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release M Koch, T Enzlein, SY Chen, D Petit, S Lismont, M Zacharias, C Hopf, ... The EMBO Journal 42 (23), e114372, 2023 | 7 | 2023 |
| Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site SY Chen, LP Feilen, L Chávez-Gutiérrez, H Steiner, M Zacharias Communications Biology 6 (1), 670, 2023 | 6 | 2023 |
| Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis LP Feilen, SY Chen, A Fukumori, R Feederle, M Zacharias, H Steiner Elife 11, e76090, 2022 | 6 | 2022 |
| Unraveling the mechanism of small molecule induced activation of Staphylococcus aureus signal peptidase IB SY Chen, MK Fiedler, TF Gronauer, O Omelko, MK von Wrisberg, T Wang, ... Communications Biology 7 (1), 895, 2024 | 1 | 2024 |
| How Modulator Binding at the Amyloidβ-γ-Secretase Interface Enhances Substrate Binding and Attenuates Membrane Distortion SY Chen, M Koch, L Chávez-Gutiérrez, M Zacharias Journal of Medicinal Chemistry 66 (24), 16772-16782, 2023 | 1 | 2023 |
| A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites JN Dienemann, SY Chen, M Hitzenberger, ML Sievert, SM Hacker, ... Angewandte Chemie International Edition 62 (31), e202304533, 2023 | 1 | 2023 |
| Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action D Schum, FAV Elsen, S Ruddell, K Schorpp, H Junca, M Müsken, ... JACS Au 4 (8), 3125-3134, 2024 | | 2024 |
| Eine chemisch‐proteomische Strategie identifiziert Inhibitoren der Lipoat‐Wiederverwertung in Bakterien und Parasiten JN Dienemann, SY Chen, M Hitzenberger, ML Sievert, SM Hacker, ... Angewandte Chemie 135 (31), e202304533, 2023 | | 2023 |
| APP substrate ectodomain defines amyloid-b peptide length by restraining c-secretase processivity and facilitating product release M Koch, T Enzlein, SY Chen, D Petit, S Lismont, M Zacharias, C Hopf, ... The EMBO Journal 114372, e114372, 2023 | | 2023 |
