A single molecular descriptor to predict solution behavior of therapeutic antibodies JS Kingsbury, A Saini, SM Auclair, L Fu, MM Lantz, KT Halloran, ... Science Advances 6 (32), eabb0372, 2020 | 109 | 2020 |
The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal: direct analysis by fluorescence-detected analytical ultracentrifugation JS Kingsbury, TM Laue, ES Klimtchuk, R Théberge, CE Costello, ... Journal of Biological Chemistry 283 (18), 11887-11896, 2008 | 74 | 2008 |
Fluorescence-detected sedimentation in dilute and highly concentrated solutions JS Kingsbury, TM Laue Methods in enzymology 492, 283-304, 2011 | 48 | 2011 |
Detailed structural analysis of amyloidogenic wild-type transthyretin using a novel purification strategy and mass spectrometry JS Kingsbury, R Théberge, JA Karbassi, A Lim, CE Costello, LH Connors Analytical chemistry 79 (5), 1990-1998, 2007 | 48 | 2007 |
Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin JS Kingsbury, ES Klimtchuk, R Théberge, CE Costello, LH Connors Protein expression and purification 53 (2), 370-377, 2007 | 38 | 2007 |
Valence and anion binding of bovine ribonuclease A between pH 6 and 8 TP Moody, JS Kingsbury, JA Durant, TJ Wilson, SF Chase, TM Laue Analytical biochemistry 336 (2), 243-252, 2005 | 35 | 2005 |
Machine learning feature selection for predicting high concentration therapeutic antibody aggregation PK Lai, A Fernando, TK Cloutier, JS Kingsbury, Y Gokarn, KT Halloran, ... Journal of Pharmaceutical Sciences 110 (4), 1583-1591, 2021 | 30 | 2021 |
Site-specific PEGylation of human thyroid stimulating hormone to prolong duration of action H Qiu, E Boudanova, A Park, JJ Bird, DM Honey, C Zarazinski, B Greene, ... Bioconjugate chemistry 24 (3), 408-418, 2013 | 29 | 2013 |
Impact of cysteine variants on the structure, activity, and stability of recombinant human α‐galactosidase A H Qiu, DM Honey, JS Kingsbury, A Park, E Boudanova, RR Wei, CQ Pan, ... Protein Science 24 (9), 1401-1411, 2015 | 28 | 2015 |
Ultradilute measurements of self-association for the identification of antibodies with favorable high-concentration solution properties CG Starr, EK Makowski, L Wu, B Berg, JS Kingsbury, YR Gokarn, ... Molecular Pharmaceutics 18 (7), 2744-2753, 2021 | 25 | 2021 |
Carbohydrate-mediated polyethylene glycol conjugation of TSH improves its pharmacological properties A Park, DM Honey, L Hou, JJ Bird, C Zarazinski, M Searles, C Braithwaite, ... Endocrinology 154 (3), 1373-1383, 2013 | 21 | 2013 |
Detection of high-molecular-weight amyloid serum protein complexes using biological on-line tracer sedimentation JS Kingsbury, TM Laue, SF Chase, LH Connors Analytical biochemistry 425 (2), 151-156, 2012 | 10 | 2012 |
A single molecular descriptor to predict solution behavior of therapeutic antibodies. Sci Adv 6: eabb0372 JS Kingsbury, A Saini, SM Auclair, L Fu, MM Lantz, KT Halloran, ... | 4 | 2020 |
Characterization of opalescence in low volume monoclonal antibody solutions enabled by microscale nephelometry JS Kingsbury, MM Lantz, A Saini, MZ Wang, YR Gokarn Journal of Pharmaceutical Sciences 110 (9), 3176-3182, 2021 | 2 | 2021 |
Combining scattering experiments and colloid theory to characterize charge effects in concentrated antibody solutions A Gulotta, M Polimeni, S Lenton, CG Starr, A Stradner, E Zaccarelli, ... Molecular Pharmaceutics 21 (5), 2250-2271, 2024 | 1 | 2024 |
Computational Screening for mAb Colloidal Stability with Coarse-Grained, Molecular-Scale Simulations JJ Janke, CG Starr, JS Kingsbury, N Furtmann, CJ Roberts, ... The Journal of Physical Chemistry B 128 (6), 1515-1526, 2024 | 1 | 2024 |
Means for antibody characterization Y Gokarn, J Kingsbury, CG Starr, PM Tessier US Patent App. 18/269,118, 2024 | | 2024 |
Native and Non-Native aggregation pathways of antibodies anticipated by cold-accelerated studies MA Rodrigues, A Duarte, V Geraldes, JS Kingsbury, P Sanket, V Filipe, ... European Journal of Pharmaceutics and Biopharmaceutics 192, 174-184, 2023 | | 2023 |
AF4 and PEG Precipitation as Predictive Assays for Antibody Self-Association I Condado-Morales, V Sokolova, PO Wahlund, KE Heding, S Auclair, ... Molecular Pharmaceutics 20 (2), 1323-1330, 2023 | | 2023 |
Preformulation of New Biological Entities R Torosantucci, V Filipe, J Kingsbury, A Saluja, Y Gokarn Parenteral Medications, Fourth Edition, 69-91, 2019 | | 2019 |