β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade F Zhang, M Gannon, Y Chen, S Yan, S Zhang, W Feng, J Tao, B Sha, ... Science translational medicine 12 (526), eaay6931, 2020 | 116 | 2020 |
Role of the Active Site Guanine in the glmS Ribozyme Self-Cleavage Mechanism: Quantum Mechanical/Molecular Mechanical Free Energy Simulations S Zhang, A Ganguly, P Goyal, JL Bingaman, PC Bevilacqua, ... Journal of the American Chemical Society 137 (2), 784-798, 2015 | 64 | 2015 |
The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme JL Bingaman, S Zhang, DR Stevens, NH Yennawar, S Hammes-Schiffer, ... Nature chemical biology 13 (4), 439-445, 2017 | 48 | 2017 |
Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro CJ Landis, S Zhang, GA Benavides, SE Scott, Y Li, M Redmann, AN Tran, ... ACS chemical biology 13 (8), 2048-2057, 2018 | 28 | 2018 |
Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design S Zhang, A Garzan, N Haese, R Bostwick, Y Martinez-Gzegozewska, ... PLoS One 16 (1), e0245013, 2021 | 27 | 2021 |
A role for GLUT3 in glioblastoma cell invasion that is not recapitulated by GLUT1 CJ Libby, S Gc, GA Benavides, JL Fisher, SE Williford, S Zhang, AN Tran, ... Cell Adhesion & Migration 15 (1), 101-115, 2021 | 25 | 2021 |
Synthesis and structure–activity relationships of 5′-aryl-14-alkoxypyridomorphinans: Identification of a μ opioid receptor agonist/δ opioid receptor antagonist ligand with … RH Vekariya, W Lei, A Ray, SK Saini, S Zhang, G Molnar, D Barlow, ... Journal of medicinal chemistry 63 (14), 7663-7694, 2020 | 24 | 2020 |
Targeting the HuR oncogenic role with a new class of cytoplasmic dimerization inhibitors N Filippova, X Yang, S Ananthan, J Calano, V Pathak, L Bratton, ... Cancer research 81 (8), 2220-2233, 2021 | 23 | 2021 |
Assessing the Potential Effects of Active Site Mg2+ Ions in the glmS Ribozyme–Cofactor Complex S Zhang, DR Stevens, P Goyal, JL Bingaman, PC Bevilacqua, ... The Journal of Physical Chemistry Letters 7 (19), 3984-3988, 2016 | 18 | 2016 |
Discovery of novel delta opioid receptor (DOR) inverse agonist and irreversible (non-competitive) antagonists P Tanguturi, V Pathak, S Zhang, O Moukha-Chafiq, CE Augelli-Szafran, ... Molecules 26 (21), 6693, 2021 | 10 | 2021 |
Targeting chikungunya virus replication by benzoannulene inhibitors SK Ahmed, NN Haese, JT Cowan, V Pathak, O Moukha-Chafiq, VJ Smith, ... Journal of medicinal chemistry 64 (8), 4762-4786, 2021 | 10 | 2021 |
Inhibitors of HIV-1 Nef-mediated activation of the myeloid Src-family kinase Hck block HIV-1 replication in macrophages and disrupt MHC-I downregulation LA Emert-Sedlak, O Moukha-Chafiq, H Shi, S Du, JJ Alvarado, V Pathak, ... ACS infectious diseases 8 (1), 91-105, 2022 | 9 | 2022 |
Efficient expression and purification of methyltransferase in acetyl-coenzyme A synthesis pathway of the human pathogen Clostridium difficile X Zhu, X Gu, S Zhang, Y Liu, ZX Huang, X Tan Protein Expression and Purification 78 (1), 86-93, 2011 | 8 | 2011 |
Identification of quinolinones as antivirals against venezuelan equine Encephalitis virus NN Haese, NA May, S Taft-Benz, O Moukha-Chafiq, N Madadi, S Zhang, ... Antimicrobial agents and chemotherapy 65 (9), 10.1128/aac. 00244-21, 2021 | 6 | 2021 |
Structural and functional insights into corrinoid iron-sulfur protein from human pathogen Clostridium difficile Y Wei, X Zhu, S Zhang, X Tan Journal of inorganic biochemistry 170, 26-33, 2017 | 6 | 2017 |
Structural and functional investigation into acetyl-coenzyme A synthase and methyltransferase from human pathogen Clostridium difficile X Zhu, T Li, X Gu, S Zhang, Y Liu, Y Wang, X Tan Metallomics 5 (5), 551-558, 2013 | 6 | 2013 |
Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals MF Yatchang, B Mathew, RK Srivastava, J Khan, S Muzaffar, S Zhang, ... Bioorganic & medicinal chemistry letters 64, 128696, 2022 | 4 | 2022 |
Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl) thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS B Mathew, P Ruiz, S Dutta, JT Entrekin, S Zhang, KD Patel, MS Simmons, ... European Journal of Medicinal Chemistry 210, 112952, 2021 | 4 | 2021 |
Activation of a novel α2AAR-spinophilin-cofilin axis determines the effect of α2 adrenergic drugs on fear memory reconsolidation S Saggu, Y Chen, C Cottingham, H Rehman, H Wang, S Zhang, ... Molecular Psychiatry 28 (2), 588-600, 2023 | 3 | 2023 |
The D3 receptor antagonist SR 21502 reduces cue-induced reinstatement of methamphetamine-seeking in rats R Ranaldi, P Timken, D Parasram, T Ali, S Zhang, O Moukha-Chafiq, ... Neuroscience letters 806, 137237, 2023 | | 2023 |