Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease A Snellman, FR López-Picón, J Rokka, M Salmona, G Forloni, M Scheinin, ... Journal of nuclear medicine 54 (8), 1434-1441, 2013 | 90 | 2013 |
Pharmacokinetics of [18F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer’s disease A Snellman, J Rokka, FR Lopez-Picon, O Eskola, I Wilson, G Farrar, ... European journal of nuclear medicine and molecular imaging 39, 1784-1795, 2012 | 72 | 2012 |
Transcriptome analysis of the hippocampal CA1 pyramidal cell region after kainic acid-induced status epilepticus in juvenile rats HB Lauren, FR Lopez-Picon, AM Brandt, CJ Rios-Rojas, IE Holopainen PloS one 5 (5), e10733, 2010 | 67 | 2010 |
Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells R Pihlaja, J Takkinen, O Eskola, J Vasara, FR López-Picón, ... Journal of Neuroinflammation 12, 1-6, 2015 | 66 | 2015 |
Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging JS Takkinen, FR Lopez-Picon, R Al Majidi, O Eskola, A Krzyczmonik, ... Journal of Cerebral Blood Flow & Metabolism 37 (8), 2870-2882, 2017 | 62 | 2017 |
Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus JT Järvelä, FR Lopez-Picon, A Plysjuk, S Ruohonen, IE Holopainen Journal of Neuroinflammation 8, 1-12, 2011 | 56 | 2011 |
Changes in microtubule-associated protein-2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus NS Jalava, FR Lopez-Picon, TK Kukko-Lukjanov, IE Holopainen International journal of developmental neuroscience 25 (2), 121-131, 2007 | 54 | 2007 |
Neuroinflammation appears early on PET imaging and then plateaus in a mouse model of Alzheimer disease FR López-Picón, A Snellman, O Eskola, S Helin, O Solin, ... Journal of Nuclear Medicine 59 (3), 509-515, 2018 | 53 | 2018 |
Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study AM Chaney, FR Lopez-Picon, S Serrière, R Wang, D Bochicchio, ... Theranostics 11 (14), 6644, 2021 | 50 | 2021 |
Mechanisms of kainate-induced region-specific neuronal death in immature organotypic hippocampal slice cultures IE Holopainen, J Järvelä, FR Lopez-Picon, LJ Pelliniemi, ... Neurochemistry international 45 (1), 1-10, 2004 | 45 | 2004 |
Kainic acid‐induced status epilepticus alters GABAA receptor subunit mRNA and protein expression in the developing rat hippocampus HB Laurén, FR Lopez‐Picon, ER Korpi, IE Holopainen Journal of neurochemistry 94 (5), 1384-1394, 2005 | 42 | 2005 |
Differential expression and localization of the phosphorylated and nonphosphorylated neurofilaments during the early postnatal development of rat hippocampus FR Lopez‐Picon, M Uusi‐Oukari, IE Holopainen Hippocampus 13 (7), 767-779, 2003 | 35 | 2003 |
[18F] F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease T Keller, FR López-Picón, A Krzyczmonik, S Forsback, AK Kirjavainen, ... Nuclear Medicine and Biology 67, 1-9, 2018 | 30 | 2018 |
The calpain inhibitor MDL‐28170 and the AMPA/KA receptor antagonist CNQX inhibit neurofilament degradation and enhance neuronal survival in kainic acid‐treated hippocampal … FR Lopez‐Picon, TK Kukko‐Lukjanov, IE Holopainen European Journal of Neuroscience 23 (10), 2686-2694, 2006 | 30 | 2006 |
Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist L Zhang, X Zhuang, P Kotitalo, T Keller, A Krzyczmonik, ... Theranostics 11 (3), 1147, 2021 | 29 | 2021 |
In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol A Snellman, J Rokka, FR López-Picón, O Eskola, M Salmona, G Forloni, ... EJNMMI research 4, 1-11, 2014 | 29 | 2014 |
Comparison of high and low molar activity TSPO tracer [18F]F-DPA in a mouse model of Alzheimer’s disease T Keller, FR López-Picón, A Krzyczmonik, S Forsback, JS Takkinen, ... Journal of Cerebral Blood Flow & Metabolism 40 (5), 1012-1020, 2020 | 27 | 2020 |
[18F] FMPEP-d2 PET imaging shows age-and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer's disease JS Takkinen, FR López-Picón, AK Kirjavainen, R Pihlaja, A Snellman, ... Neurobiology of Aging 69, 199-208, 2018 | 26 | 2018 |
Resistance of neurofilaments to degradation, and lack of neuronal death and mossy fiber sprouting after kainic acid-induced status epilepticus in the developing rat hippocampus F Lopez-Picon, N Puustinen, TK Kukko-Lukjanov, IE Holopainen Neurobiology of disease 17 (3), 415-426, 2004 | 26 | 2004 |
Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice TK Kukko-Lukjanov, M Lintunen, N Jalava, HB Laurén, FR Lopez-Picon, ... Epilepsy research 90 (1-2), 8-15, 2010 | 25 | 2010 |