Evolution of Salmonella-host cell interactions through a dynamic bacterial genome B Ilyas, CN Tsai, BK Coombes Frontiers in cellular and infection microbiology 7, 428, 2017 | 132 | 2017 |
Selection maintains signaling function of a highly diverged intrinsically disordered region T Zarin, CN Tsai, ANN Ba, AM Moses Proceedings of the National Academy of Sciences 114 (8), E1450-E1459, 2017 | 77 | 2017 |
Host-Specific Adaptive Diversification of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli W Elhenawy, CN Tsai, BK Coombes Cell host & microbe 25 (2), 301-312. e5, 2019 | 66 | 2019 |
A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium MJ Ellis, CN Tsai, JW Johnson, S French, W Elhenawy, S Porwollik, ... Nature communications 10 (1), 1-14, 2019 | 66 | 2019 |
High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli W Elhenawy, S Hordienko, S Gould, AM Oberc, CN Tsai, TP Hubbard, ... Nature Communications 12 (1), 1-13, 2021 | 45 | 2021 |
Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens LA Carfrae, CR MacNair, CM Brown, CN Tsai, BS Weber, S Zlitni, VN Rao, ... Nature microbiology 5 (1), 93-101, 2020 | 41 | 2020 |
Creative targeting of the Gram‐negative outer membrane in antibiotic discovery CR MacNair, CN Tsai, ED Brown Annals of the New York Academy of Sciences 1459 (1), 69-85, 2020 | 38 | 2020 |
Targeting two-component systems uncovers a small-molecule inhibitor of Salmonella virulence CN Tsai, CR MacNair, MPT Cao, JN Perry, J Magolan, ED Brown, ... Cell chemical biology 27 (7), 793-805. e7, 2020 | 35 | 2020 |
The role of the host in driving phenotypic heterogeneity in Salmonella CN Tsai, BK Coombes Trends in microbiology 27 (6), 508-523, 2019 | 30 | 2019 |
Regulatory evolution drives evasion of host inflammasomes by Salmonella Typhimurium B Ilyas, DT Mulder, DJ Little, W Elhenawy, MM Banda, D Pérez-Morales, ... Cell Reports 25 (4), 825-832. e5, 2018 | 30 | 2018 |
Antibiotics Potentiate Adherent-Invasive E. coli Infection and Expansion AM Oberc, AA Fiebig-Comyn, CN Tsai, W Elhenawy, BK Coombes Inflammatory bowel diseases 25 (4), 711-721, 2019 | 27 | 2019 |
Inhibiting fatty acid synthesis overcomes colistin resistance LA Carfrae, K Rachwalski, S French, R Gordzevich, L Seidel, CN Tsai, ... Nature Microbiology 8 (6), 1026-1038, 2023 | 24 | 2023 |
Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria K Klobucar, E Jardine, MA Farha, MR MacKinnon, M Fragis, B Nkonge, ... ACS Infectious Diseases 8 (10), 2187-2197, 2022 | 10 | 2022 |
Genetic contributions to ectopic sperm cell migration in Caenorhabditis nematodes JJ Ting, CN Tsai, R Schalkowski, AD Cutter G3: Genes, Genomes, Genetics 8 (12), 3891-3902, 2018 | 8 | 2018 |
Returning to Nature for the Next Generation of Antimicrobial Therapeutics CR MacNair, CN Tsai, ST Rutherford, MW Tan Antibiotics 12 (8), 1267, 2023 | 5 | 2023 |
Emergence of invasive Salmonella in Africa CN Tsai, BK Coombes Nature Microbiology 6 (3), 273-274, 2021 | 5 | 2021 |
Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal Salmonella (iNTS) CN Tsai, MA Massicotte, CR MacNair, J Perry, ED Brown, B Coombes RSC Chemical Biology, 2023 | | 2023 |
High-Throughput Chemical Screening for Inhibitors of Salmonella Pathogenicity Island 2 CN Tsai, BK Coombes STAR Protocols 1 (2), 100057, 2020 | | 2020 |