| An integrated encyclopedia of DNA elements in the human genome ENCODE Project Consortium Nature 489 (7414), 57-74, 2012 | 16820 | 2012 |
| The accessible chromatin landscape of the human genome RE Thurman, E Rynes, R Humbert, J Vierstra, MT Maurano, E Haugen, ... Nature 489 (7414), 75-82, 2012 | 3093 | 2012 |
| A map of open chromatin in human pancreatic islets KJ Gaulton, T Nammo, L Pasquali, JM Simon, PG Giresi, MP Fogarty, ... Nature genetics 42 (3), 255-259, 2010 | 648 | 2010 |
| Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity L Song, Z Zhang, LL Grasfeder, AP Boyle, PG Giresi, BK Lee, ... Genome research 21 (10), 1757-1767, 2011 | 628 | 2011 |
| Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA JM Simon, PG Giresi, IJ Davis, JD Lieb Nature protocols 7 (2), 256-267, 2012 | 414 | 2012 |
| Single-cell transcriptomic analysis of mouse neocortical development L Loo, JM Simon, L Xing, ES McCoy, JK Niehaus, J Guo, ES Anton, ... Nature communications 10 (1), 134, 2019 | 261 | 2019 |
| An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation GP Souroullas, WR Jeck, JS Parker, JM Simon, JY Liu, J Paulk, J Xiong, ... Nature medicine 22 (6), 632-640, 2016 | 215 | 2016 |
| Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects JM Simon, KE Hacker, D Singh, AR Brannon, JS Parker, M Weiser, TH Ho, ... Genome research 24 (2), 241-250, 2014 | 206 | 2014 |
| VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma J Zhang, T Wu, J Simon, M Takada, R Saito, C Fan, XD Liu, E Jonasch, ... Science 361 (6399), 290-295, 2018 | 145 | 2018 |
| BRG1/SMARCA4 inactivation promotes non–small cell lung cancer aggressiveness by altering chromatin organization T Orvis, A Hepperla, V Walter, S Song, J Simon, J Parker, MD Wilkerson, ... Cancer research 74 (22), 6486-6498, 2014 | 139 | 2014 |
| Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration BL Pearson, JM Simon, ES McCoy, G Salazar, G Fragola, MJ Zylka Nature communications 7 (1), 11173, 2016 | 129 | 2016 |
| Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription M Patel, JM Simon, MD Iglesia, SB Wu, AW McFadden, JD Lieb, IJ Davis Genome research 22 (2), 259-270, 2012 | 128 | 2012 |
| Gene length matters in neurons MJ Zylka, JM Simon, BD Philpot Neuron 86 (2), 353-355, 2015 | 124 | 2015 |
| Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA JM Wolter, H Mao, G Fragola, JM Simon, JL Krantz, HO Bazick, B Oztemiz, ... Nature 587 (7833), 281-284, 2020 | 119 | 2020 |
| Molecular classification of Crohn's disease reveals two clinically relevant subtypes M Weiser, JM Simon, B Kochar, A Tovar, JW Israel, A Robinson, ... Gut, gutjnl-2016-312518, 2016 | 119 | 2016 |
| scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy JK Ocasio, B Babcock, D Malawsky, SJ Weir, L Loo, JM Simon, MJ Zylka, ... Nature communications 10 (1), 5829, 2019 | 96 | 2019 |
| A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder BDN Phan, JF Bohlen, BA Davis, Z Ye, HY Chen, B Mayfield, SR Sripathy, ... Nature neuroscience 23 (3), 375-385, 2020 | 95 | 2020 |
| Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models J Guo, JM Otis, SK Suciu, C Catalano, L Xing, S Constable, D Wachten, ... Developmental Cell 51 (6), 759-774. e5, 2019 | 87 | 2019 |
| Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury JK Niehaus, B Taylor-Blake, L Loo, JM Simon, MJ Zylka Neuron 109 (8), 1274-1282. e6, 2021 | 82 | 2021 |
| Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma RS McNeill, DA Canoutas, TJ Stuhlmiller, HD Dhruv, DM Irvin, RE Bash, ... Neuro-oncology 19 (11), 1469-1480, 2017 | 58 | 2017 |
Mark J. ZylkaThe University of North Carolina at Chapel Hill在 med.unc.edu 的电子邮件经过验证
