The microbial metabolite desaminotyrosine protects from influenza through type I interferon AL Steed, GP Christophi, GE Kaiko, L Sun, VM Goodwin, U Jain, ... Science 357 (6350), 498-502, 2017 | 470 | 2017 |
Debaryomyces is enriched in Crohn’s disease intestinal tissue and impairs healing in mice U Jain, AM Ver Heul, S Xiong, MH Gregory, EG Demers, JT Kern, CW Lai, ... Science 371 (6534), 1154-1159, 2021 | 161 | 2021 |
Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation TC Liu, JT Kern, U Jain, NM Sonnek, S Xiong, KF Simpson, ... Cell host & microbe 29 (6), 988-1001. e6, 2021 | 100 | 2021 |
Do antimicrobial peptides and complement collaborate in the intestinal mucosa? ZA Kopp, U Jain, J Van Limbergen, AW Stadnyk Frontiers in immunology 6, 17, 2015 | 74 | 2015 |
The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL‐4 and IL‐10 U Jain, TM Woodruff, AW Stadnyk British journal of pharmacology 168 (2), 488-501, 2013 | 74 | 2013 |
PAI-1 augments mucosal damage in colitis GE Kaiko, F Chen, CW Lai, IL Chiang, J Perrigoue, A Stojmirović, K Li, ... Science translational medicine 11 (482), eaat0852, 2019 | 65 | 2019 |
The complement system in inflammatory bowel disease U Jain, AR Otley, J Van Limbergen, AW Stadnyk Inflammatory bowel diseases 20 (9), 1628-1637, 2014 | 56 | 2014 |
Temporal regulation of the bacterial metabolite deoxycholate during colonic repair is critical for crypt regeneration U Jain, CW Lai, S Xiong, VM Goodwin, Q Lu, BD Muegge, GP Christophi, ... Cell host & microbe 24 (3), 353-363. e5, 2018 | 55 | 2018 |
Properdin provides protection from citrobacter rodentium–induced intestinal inflammation in a C5a/IL-6–dependent manner U Jain, Q Cao, NA Thomas, TM Woodruff, WJ Schwaeble, CM Stover, ... The Journal of Immunology 194 (7), 3414-3421, 2015 | 26 | 2015 |
Reverse translation approach generates a signature of penetrating fibrosis in Crohn’s disease that is associated with anti-TNF response S Xiong, CE Whitehurst, L Li, GS Heo, CW Lai, U Jain, BD Muegge, ... Gut 71 (7), 1289-1301, 2022 | 17 | 2022 |
Properdin Regulation of Complement Activation Affects Colitis in Interleukin 10 Gene–Deficient Mice U Jain, CA Midgen, WJ Schwaeble, CM Stover, AW Stadnyk Inflammatory bowel diseases 21 (7), 1519-1528, 2015 | 15 | 2015 |
Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanism U Jain, CA Midgen, TM Woodruff, WJ Schwaeble, CM Stover, AW Stadnyk Clinical & Experimental Immunology 188 (1), 36-44, 2017 | 14 | 2017 |
Tandem tyrosine phosphosites in the Enteropathogenic Escherichia coli chaperone CesT are required for differential type III effector translocation and virulence CS Runte, U Jain, LJ Getz, S Secord, A Kuwae, A Abe, JJ LeBlanc, ... Molecular Microbiology 108 (5), 536-550, 2018 | 11 | 2018 |
Erdheim-Chester Disease presenting with histiocytic colitis and cytokine storm. GP Christophi, Y Sharma, Q Farhan, U Jain, T Walker, GS Sayuk, ... Journal of Gastrointestinal & Liver Diseases 26 (2), 2017 | 7 | 2017 |
Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair P Mehrotra, S Maschalidi, L Boeckaerts, C Maueröder, R Tixeira, J Pinney, ... Nature, 1-9, 2024 | 3 | 2024 |
NAD+ precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction A Malique, S Sun, K Chandwe, B Amadi, T Haritunians, U Jain, ... Science translational medicine 16 (728), eabq4145, 2024 | 1 | 2024 |
INSIGHTS INTO THE ROLE OF COMPLEMENT DURING INTESTINAL INFLAMMATION U Jain | | 2016 |
Properdin mediates complement activation and is protective against infectious colitis (902.6) U Jain, N Thomas, C Stover, A Stadnyk The FASEB Journal 28, 902.6, 2014 | | 2014 |
Antagonizing C5aR reduces T Cell-IL-10-dependent colitis in pre-clinical models U Jain, T Woodruff, A Stadnyk Inflammatory Bowel Diseases 18 (Supplement 1), S110-S110, 2012 | | 2012 |