| β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy C Soto, EM Sigurdsson, L Morelli, R Asok Kumar, EM Castaño, ... Nature medicine 4 (7), 822-826, 1998 | 1115 | 1998 |
| New insights into the genetic etiology of Alzheimer’s disease and related dementias C Bellenguez, F Küçükali, IE Jansen, L Kleineidam, S Moreno-Grau, ... Nature genetics 54 (4), 412-436, 2022 | 1102 | 2022 |
| Degradation of soluble amyloid β-peptides 1–40, 1–42, and the Dutch variant 1–40Q by insulin degrading enzyme from Alzheimer disease and control brains A Pérez, L Morelli, JC Cresto, EM Castaño Neurochemical research 25, 247-255, 2000 | 315 | 2000 |
| Defective ubiquitination of cerebral proteins in Alzheimer's disease M López Salon, L Morelli, EM Castano, EF Soto, JM Pasquini Journal of neuroscience research 62 (2), 302-310, 2000 | 269 | 2000 |
| Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores I De Rojas, S Moreno-Grau, N Tesi, B Grenier-Boley, V Andrade, ... Nature communications 12 (1), 3417, 2021 | 201 | 2021 |
| Insulin-degrading enzyme sorting in exosomes: A secretory pathway for a key brain amyloid-β degrading protease A Bulloj, MC Leal, H Xu, EM Castaño, L Morelli Journal of Alzheimer's Disease 19 (1), 79-95, 2010 | 162 | 2010 |
| Carbohydrates and immunology: synthetic oligosaccharide antigens for vaccine formulation L Morelli, L Poletti, L Lay European Journal of Organic Chemistry 2011 (29), 5723-5777, 2011 | 136 | 2011 |
| Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease A Fernandez-Gamba, MC Leal, L Morelli, EM Castaño Current pharmaceutical design 15 (31), 3644-3655, 2009 | 131 | 2009 |
| The cell cycle in Alzheimer disease: a unique target for neuropharmacology KM Webber, AK Raina, MW Marlatt, X Zhu, MI Prat, L Morelli, ... Mechanisms of ageing and development 126 (10), 1019-1025, 2005 | 129 | 2005 |
| Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease VB Dorfman, L Pasquini, M Riudavets, JJ López-Costa, A Villegas, ... Neurobiology of aging 31 (10), 1743-1757, 2010 | 109 | 2010 |
| Differential degradation of amyloid β genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme L Morelli, R Llovera, SA Gonzalez, JL Affranchino, F Prelli, B Frangione, ... Journal of biological chemistry 278 (26), 23221-23226, 2003 | 104 | 2003 |
| Dementia in Latin America: paving the way toward a regional action plan MA Parra, S Baez, L Sedeño, C Gonzalez Campo, H Santamaría‐García, ... Alzheimer's & Dementia 17 (2), 295-313, 2021 | 98 | 2021 |
| Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology MC Leal, VB Dorfman, AF Gamba, B Frangione, T Wisniewski, ... Journal of Neuropathology & Experimental Neurology 65 (10), 976-987, 2006 | 97 | 2006 |
| Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer's disease P Galeano, PV Martino Adami, S Do Carmo, E Blanco, C Rotondaro, ... Frontiers in behavioral neuroscience 8, 321, 2014 | 92 | 2014 |
| Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid β vasculotropic variants and reduced activity in cerebral amyloid angiopathy L Morelli, RE Llovera, I Mathov, LF Lue, B Frangione, J Ghiso, ... Journal of Biological Chemistry 279 (53), 56004-56013, 2004 | 88 | 2004 |
| Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP‐1‐associated regulator of cyclin B, in Alzheimer's disease X Zhu, A McShea, PLR Harris, AK Raina, RJ Castellani, JO Funk, S Shah, ... Journal of neuroscience research 75 (5), 698-703, 2004 | 85 | 2004 |
| Activation of Hsp90 enzymatic activity and conformational dynamics through rationally designed allosteric ligands S Sattin, J Tao, G Vettoretti, E Moroni, M Pennati, A Lopergolo, L Morelli, ... Chemistry–A European Journal 21 (39), 13598-13608, 2015 | 78 | 2015 |
| Structure of the type IX group B Streptococcus capsular polysaccharide and its evolutionary relationship with types V and VII F Berti, E Campisi, C Toniolo, L Morelli, S Crotti, R Rosini, MR Romano, ... Journal of Biological Chemistry 289 (34), 23437-23448, 2014 | 76 | 2014 |
| New insights on the genetic etiology of Alzheimer’s and related dementia C Bellenguez, F Küçükali, I Jansen, V Andrade, S Moreno-Grau, N Amin, ... MedRxiv, 2020.10. 01.20200659, 2020 | 73 | 2020 |
| Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation A Bulloj, MC Leal, EI Surace, X Zhang, H Xu, MD Ledesma, EM Castaño, ... Molecular neurodegeneration 3, 1-13, 2008 | 64 | 2008 |
