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Simon Linder
Simon Linder
在 dkfz-heidelberg.de 的电子邮件经过验证
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An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer
A Davies, S Nouruzi, D Ganguli, T Namekawa, D Thaper, S Linder, ...
Nature cell biology 23 (9), 1023-1034, 2021
1142021
Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond
S Linder, HG van der Poel, AM Bergman, W Zwart, S Prekovic
Endocrine-related cancer 26 (1), R31-R52, 2019
722019
Optimized ChIP-seq method facilitates transcription factor profiling in human tumors
AA Singh, K Schuurman, E Nevedomskaya, S Stelloo, S Linder, M Droog, ...
Life science alliance 2 (1), 2019
532019
Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer toward androgen independence
S Linder, M Hoogstraat, S Stelloo, N Eickhoff, K Schuurman, H de Barros, ...
Cancer discovery 12 (9), 2074-2097, 2022
492022
Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division
ARR Maia, S Linder, JY Song, C Vaarting, U Boon, CEJ Pritchard, A Velds, ...
British Journal of Cancer 118 (12), 1586-1595, 2018
452018
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer
T Bernasocchi, G El Tekle, M Bolis, A Mutti, A Vallerga, LP Brandt, ...
Nature communications 12 (1), 734, 2021
392021
Molecular underpinnings of enzalutamide resistance
S Prekovic, T Van den Broeck, S Linder, ME van Royen, AB Houtsmuller, ...
Endocrine-related cancer 25 (11), R545-R557, 2018
382018
Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation
SC Baca, C Singler, S Zacharia, JH Seo, T Morova, F Hach, Y Ding, ...
Nature genetics 54 (9), 1364-1375, 2022
342022
Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer
MD Long, JJ Jacobi, PK Singh, G Llimos, SA Wani, AM Rowsam, ...
Cell reports 37 (11), 2021
282021
Functional mapping of androgen receptor enhancer activity
CCF Huang, S Lingadahalli, T Morova, D Ozturan, E Hu, IPL Yu, S Linder, ...
Genome biology 22 (1), 149, 2021
232021
Transposable elements are co-opted as oncogenic regulatory elements by lineage-specific transcription factors in prostate cancer
G Grillo, T Keshavarzian, S Linder, C Arlidge, L Mout, A Nand, M Teng, ...
Cancer discovery 13 (11), 2470-2487, 2023
142023
A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated …
SAL Palit, J van Dorp, D Vis, C Lieftink, S Linder, R Beijersbergen, ...
Scientific reports 11 (1), 13683, 2021
142021
Radiogenomics analysis linking multiparametric MRI and transcriptomics in prostate cancer
C Dinis Fernandes, A Schaap, J Kant, P van Houdt, H Wijkstra, E Bekers, ...
Cancers 15 (12), 3074, 2023
102023
Androgen modulation of XBP1 is functionally driving part of the AR transcriptional program
S Stelloo, S Linder, E Nevedomskaya, E Valle-Encinas, I de Rink, ...
Endocrine-related cancer 27 (2), 67-79, 2020
102020
Grade Group 1 Prostate Cancers Exhibit Tumor-defining Androgen Receptor–driven Programs
S Linder, TM Severson, KJC van der Mijn, E Nevedomskaya, JC Siefert, ...
European Urology 84 (5), 455-460, 2023
72023
Unexpected gene activation following CRISPR‐Cas9‐mediated genome editing
AG Manjón, S Linder, H Teunissen, A Friskes, W Zwart, E de Wit, ...
EMBO reports 23 (2), e53902, 2022
72022
Enhancer profiling identifies epigenetic markers of endocrine resistance and reveals therapeutic options for metastatic castration-resistant prostate cancer patients
TM Severson, Y Zhu, S Prekovic, K Schuurman, HM Nguyen, LG Brown, ...
medRxiv, 2023.02. 24.23286403, 2023
32023
Compartmentalization of androgen receptors at endogenous genes in living cells
S Yavuz, H Kabbech, J van Staalduinen, S Linder, WA van Cappellen, ...
Nucleic Acids Research 51 (20), 10992-11009, 2023
22023
Abstract B041: AR suppresses MHC Class I expression and T-cell response in prostate cancer
L Chesner, J Graff, F Polesso, A Smith, A Lundberg, M Sjoestroem, Z Xia, ...
Cancer Research 83 (11_Supplement), B041-B041, 2023
22023
AR inhibition increases MHC class I expression and improves immune response in prostate cancer
LN Chesner, JN Graff, F Polesso, A Smith, A Lundberg, R Das, T Shenoy, ...
22023
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