| Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains JM Kavran, DE Klein, A Lee, M Falasca, SJ Isakoff, EY Skolnik, ... Journal of Biological Chemistry 273 (46), 30497-30508, 1998 | 567 | 1998 |
| The pleckstrin homology domains of dynamin isoforms require oligomerization for high affinity phosphoinositide binding DE Klein, A Lee, DW Frank, MS Marks, MA Lemmon Journal of Biological Chemistry 273 (42), 27725-27733, 1998 | 254 | 1998 |
| Structural basis for negative cooperativity in growth factor binding to an EGF receptor D Alvarado, DE Klein, MA Lemmon Cell 142 (4), 568-579, 2010 | 202 | 2010 |
| Argos inhibits epidermal growth factor receptor signalling by ligand sequestration DE Klein, VM Nappi, GT Reeves, SY Shvartsman, MA Lemmon Nature 430 (7003), 1040-1044, 2004 | 177 | 2004 |
| Structure of a dengue virus envelope protein late-stage fusion intermediate DE Klein, JL Choi, SC Harrison Journal of virology 87 (4), 2287-2293, 2013 | 140 | 2013 |
| Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation Cell 168 (6), 1053-1064. e15, 2017 | 116 | 2017 |
| Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells EL Bao, SK Nandakumar, X Liao, AG Bick, J Karjalainen, M Tabaka, ... Nature 586 (7831), 769-775, 2020 | 111 | 2020 |
| ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor D Alvarado, DE Klein, MA Lemmon Nature 461 (7261), 287-291, 2009 | 107 | 2009 |
| High-affinity binding of a FYVE domain to phosphatidylinositol 3-phosphate requires intact phospholipid but not FYVE domain oligomerization VG Sankaran, DE Klein, MM Sachdeva, MA Lemmon Biochemistry 40 (29), 8581-8587, 2001 | 96 | 2001 |
| Sequential conformational rearrangements in flavivirus membrane fusion LH Chao, DE Klein, AG Schmidt, JM Peña, SC Harrison Elife 3, e04389, 2014 | 94 | 2014 |
| Structural basis for EGFR ligand sequestration by Argos DE Klein, SE Stayrook, F Shi, K Narayan, MA Lemmon Nature 453 (7199), 1271-1275, 2008 | 64 | 2008 |
| Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics A Kiyatkin, IK van Alderwerelt van Rosenburgh, DE Klein, MA Lemmon Science Signaling 13 (645), eaaz5267, 2020 | 52 | 2020 |
| Computational analysis of EGFR inhibition by Argos GT Reeves, R Kalifa, DE Klein, MA Lemmon, SY Shvartsman Developmental biology 284 (2), 523-535, 2005 | 49 | 2005 |
| Massively parallel base editing to map variant effects in human hematopoiesis JD Martin-Rufino, N Castano, M Pang, EI Grody, S Joubran, A Caulier, ... Cell 186 (11), 2456-2474. e24, 2023 | 47 | 2023 |
| Infantile myelofibrosis and myeloproliferation with CDC42 dysfunction JM Verboon, D Mahmut, AR Kim, M Nakamura, NJ Abdulhay, ... Journal of clinical immunology 40, 554-566, 2020 | 31 | 2020 |
| Structural basis for ligand reception by anaplastic lymphoma kinase T Li, SE Stayrook, Y Tsutsui, J Zhang, Y Wang, H Li, A Proffitt, SG Krimmer, ... Nature 600 (7887), 148-152, 2021 | 28 | 2021 |
| Structural basis of neurohormone perception by the receptor tyrosine kinase Torso S Jenni, Y Goyal, M von Grotthuss, SY Shvartsman, DE Klein Molecular cell 60 (6), 941-952, 2015 | 17 | 2015 |
| Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B. 1.617 L Peng, Y Hu, MC Mankowski, P Ren, RE Chen, J Wei, M Zhao, T Li, ... Nature communications 13 (1), 1638, 2022 | 15 | 2022 |
| ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK. CAR-T cells E Bergaggio, WT Tai, A Aroldi, C Mecca, E Landoni, M Nüesch, I Mota, ... Cancer cell 41 (12), 2100-2116. e10, 2023 | 14 | 2023 |
| 7SK methylation by METTL3 promotes transcriptional activity M Perez-Pepe, AW Desotell, H Li, W Li, B Han, Q Lin, DE Klein, Y Liu, ... Science advances 9 (19), eade7500, 2023 | 9 | 2023 |
