Transglutaminase-based chemo-enzymatic conjugation approach yields homogeneous antibody–drug conjugates P Dennler, A Chiotellis, E Fischer, D Brégeon, C Belmant, L Gauthier, ... Bioconjugate chemistry 25 (3), 569-578, 2014 | 303 | 2014 |
Antibody conjugates: from heterogeneous populations to defined reagents P Dennler, E Fischer, R Schibli Antibodies 4 (3), 197-224, 2015 | 119 | 2015 |
Site-specific conjugation of monomethyl auristatin E to anti-CD30 antibodies improves their pharmacokinetics and therapeutic index in rodent models F Lhospice, D Brégeon, C Belmant, P Dennler, A Chiotellis, E Fischer, ... Molecular pharmaceutics 12 (6), 1863-1871, 2015 | 118 | 2015 |
Enzymatic conjugation of polypeptides D Bregeon, P Dennler, C Belmant, E Fischer, L Gauthier, F Romagné, ... US Patent 9,717,803, 2017 | 51 | 2017 |
DOTA-functionalized polylysine: a high number of DOTA chelates positively influences the biodistribution of enzymatic conjugated anti-tumor antibody chCE7agl J Grünberg, S Jeger, D Sarko, P Dennler, K Zimmermann, W Mier, ... PLoS One 8 (4), e60350, 2013 | 48 | 2013 |
Enzymatic conjugation of antibodies P Dennler, D Bregeon, L Gauthier, F Romagné, C Belmant, E Fischer, ... US Patent 9,764,038, 2017 | 30 | 2017 |
Microbial Transglutaminase and c‐myc‐Tag: A Strong Couple for the Functionalization of Antibody‐Like Protein Scaffolds from Discovery Platforms P Dennler, LK Bailey, PR Spycher, R Schibli, E Fischer ChemBioChem 16 (5), 861-867, 2015 | 30 | 2015 |
Enzymatic antibody modification by bacterial transglutaminase P Dennler, R Schibli, E Fischer Antibody-drug conjugates, 205-215, 2013 | 22 | 2013 |
Genomics drugs in clinical trials J Hall, P Dennler, S Haller, A Pratsinis, K Säuberli, H Towbin, K Walther, ... Nature reviews drug discovery 9 (12), 988-988, 2010 | 22 | 2010 |
Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis R Meletta, A Müller Herde, P Dennler, E Fischer, R Schibli, SD Krämer EJNMMI research 6, 1-12, 2016 | 21 | 2016 |
Synthesis, radiolabelling and in vitro and in vivo evaluation of a novel fluorinated ABP688 derivative for the PET imaging of metabotropic glutamate receptor subtype 5 SM Sephton, P Dennler, DS Leutwiler, L Mu, CA Wanger-Baumann, ... American Journal of Nuclear Medicine and Molecular Imaging 2 (1), 14, 2012 | 21 | 2012 |
Development of [18F]-PSS223 as a PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGluR5) SM Sephton, P Dennler, DS Leutwiler, L Mu, R Schibli, SD Krämer, ... Chimia 66 (4), 201-201, 2012 | 14 | 2012 |
Recognition tags for TGase-mediated conjugation E Fischer, F Romagne, P Dennler US Patent 10,036,010, 2018 | 12 | 2018 |
Screening of conjugated antibodies C Belmant, D Bregeon, P Dennler, E Fischer, F Romagne, R Schibli, ... US Patent 10,132,799, 2018 | 11 | 2018 |
Enzymatic conjugation of polypeptides D Bregeon, P Dennler, C Belmant, L Gauthier, F Romagne, E Fischer, ... US Patent 10,434,180, 2019 | 9 | 2019 |
Enzymatic conjugation of polypeptides D Bregeon, P Dennler, C Belmant, E Fischer, L Gauthier, F Romagné, ... US Patent App. 15/654,585, 2018 | 5 | 2018 |
Enzymatic conjugation of antibodies P Dennler, D Bregeon, L Gauthier, F Romagné, C Belmant, E Fischer, ... US Patent 10,675,359, 2020 | 3 | 2020 |
Recognition tags for tgase-mediated conjugation E Fischer, F Romagne, P Dennler US Patent App. 16/035,437, 2019 | 2 | 2019 |
Towards homogenous adcs: A new site-specific antibody conjugation using bacterial transglutaminase (btg-adc) F Lhospice, D Bregeon, C Belmant, A Represa, A Boedec, Y Morel, ... Cancer Research 74 (19_Supplement), 2514-2514, 2014 | 1 | 2014 |
Imaging atherosclerotic plaque inflammation with the CD80/CD86-specific In-111-DOTA-Belatacept R Meletta, AM Herde, P Dennler, E Fischer, SD Kraemer, R Schibli JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 58, S346-S346, 2015 | | 2015 |