Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning X Xiang, GI Corsi, C Anthon, K Qu, X Pan, X Liang, P Han, Z Dong, L Liu, ... Nature communications 12 (1), 3238, 2021 | 99 | 2021 |
Elevated mitochondrial DNA copy number in peripheral blood cells is associated with childhood autism S Chen, Z Li, Y He, F Zhang, H Li, Y Liao, Z Wei, G Wan, X Xiang, M Hu, ... BMC psychiatry 15, 1-7, 2015 | 77 | 2015 |
Extrachromosomal circular DNA in cancer: history, current knowledge, and methods JB Noer, OK Hørsdal, X Xiang, Y Luo, B Regenberg Trends in Genetics 38 (7), 766-781, 2022 | 75 | 2022 |
CRISPR-C: circularization of genes and chromosome by CRISPR in human cells HD Møller, L Lin, X Xiang, TS Petersen, J Huang, L Yang, E Kjeldsen, ... Nucleic acids research 46 (22), e131-e131, 2018 | 68 | 2018 |
Identification and functional characterization of mutations in LPL gene causing severe hypertriglyceridaemia and acute pancreatitis P Han, G Wei, K Cai, X Xiang, WP Deng, YB Li, S Kuang, Z Dong, ... Journal of Cellular and Molecular Medicine 24 (2), 1286-1299, 2020 | 60 | 2020 |
Production of α1, 3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning H Gao, C Zhao, X Xiang, Y Li, Y Zhao, Z Li, D Pan, Y Dai, H Hara, ... Journal of Reproduction and Development 63 (1), 17-26, 2017 | 59 | 2017 |
Shorter telomere length in peripheral blood leukocytes is associated with childhood autism Z Li, J Tang, H Li, S Chen, Y He, Y Liao, Z Wei, G Wan, X Xiang, K Xia, ... Scientific reports 4 (1), 7073, 2014 | 51 | 2014 |
Factors determining the efficiency of porcine somatic cell nuclear transfer: data analysis with over 200,000 reconstructed embryos T Liu, H Dou, X Xiang, L Li, Y Li, L Lin, X Pang, Y Zhang, Y Chen, J Luan, ... Cellular Reprogramming (Formerly" Cloning and Stem Cells") 17 (6), 463-471, 2015 | 41 | 2015 |
GNL-Scorer: a generalized model for predicting CRISPR on-target activity by machine learning and featurization J Wang, X Xiang, L Bolund, X Zhang, L Cheng, Y Luo Journal of molecular cell biology 12 (11), 909-911, 2020 | 28 | 2020 |
Efficient correction of Duchenne muscular dystrophy mutations by SpCas9 and dual gRNAs X Xiang, X Zhao, X Pan, Z Dong, J Yu, S Li, X Liang, P Han, K Qu, ... Molecular Therapy-Nucleic Acids 24, 403-415, 2021 | 21 | 2021 |
CRISPR/Cas9-mediated gene tagging: a step-by-step protocol X Xiang, C Li, X Chen, H Dou, Y Li, X Zhang, Y Luo CRISPR Gene Editing: Methods and Protocols, 255-269, 2019 | 16 | 2019 |
Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes T Zheng, J Huang, X Xiang, S Li, J Yu, K Qu, Z Xu, P Han, Z Dong, Y Liu, ... Cancer Cell International 21, 1-16, 2021 | 13 | 2021 |
Massively targeted evaluation of therapeutic CRISPR off-targets in cells X Pan, K Qu, H Yuan, X Xiang, C Anthon, L Pashkova, X Liang, P Han, ... Nature Communications 13 (1), 4049, 2022 | 12 | 2022 |
Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing J Yu, X Xiang, J Huang, X Liang, X Pan, Z Dong, TS Petersen, K Qu, ... Nucleic Acids Research 48 (5), e25-e25, 2020 | 12 | 2020 |
Genome-wide characterization of extrachromosomal circular DNA in gastric cancer and its potential role in carcinogenesis and cancer progression X Jiang, X Pan, W Li, P Han, J Yu, J Li, H Zhang, W Lv, Y Zhang, Y He, ... Cellular and Molecular Life Sciences 80 (7), 191, 2023 | 8 | 2023 |
CRISPR-GNL: an improved model for predicting CRISPR activity by machine learning and featurization J Wang, X Xiang, L Cheng, X Zhang, Y Luo bioRxiv, 605790, 2019 | 8 | 2019 |
Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression Y Sun, W Xiao, Y Yu, Y Jiang, Z Xiao, D Huang, T Zhong, J Li, X Xiang, ... Experimental Cell Research 426 (2), 113565, 2023 | 6 | 2023 |
Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy X Xiang, K Qu, X Liang, X Pan, J Wang, P Han, Z Dong, L Liu, J Zhong, ... bioRxiv, 2020.05. 20.103614, 2020 | 5 | 2020 |
LION: a simple and rapid method to achieve CRISPR gene editing X Xiang, L Luo, M Nodzyński, C Li, P Han, H Dou, TS Petersen, X Liang, ... Cellular and molecular life sciences 76, 2633-2645, 2019 | 3 | 2019 |
Circle-seq based method for eccDNA synthesis and its application as a canonical promoter independent vector for robust microRNA overexpression J Yu, H Zhang, P Han, X Jiang, J Li, B Li, S Yang, C He, S Mao, Y Dang, ... Computational and Structural Biotechnology Journal 23, 358-368, 2024 | 1 | 2024 |