Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations AV Khera, M Chaffin, KG Aragam, ME Haas, C Roselli, SH Choi, ... Nature genetics 50 (9), 1219-1224, 2018 | 2555 | 2018 |
MitoCarta3. 0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations S Rath, R Sharma, R Gupta, T Ast, C Chan, TJ Durham, RP Goodman, ... Nucleic acids research 49 (D1), D1541-D1547, 2021 | 895 | 2021 |
Polygenic prediction of weight and obesity trajectories from birth to adulthood AV Khera, M Chaffin, KH Wade, S Zahid, J Brancale, R Xia, M Distefano, ... Cell 177 (3), 587-596. e9, 2019 | 630 | 2019 |
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir, Y Zhang, ... Cell 184 (18), 4784-4818. e17, 2021 | 301 | 2021 |
Biological and clinical insights from genetics of insomnia symptoms JM Lane, SE Jones, HS Dashti, AR Wood, KG Aragam, VT van Hees, ... Nature genetics 51 (3), 387-393, 2019 | 287 | 2019 |
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3 M Qiu, Z Glass, J Chen, M Haas, X Jin, X Zhao, X Rui, Z Ye, Y Li, F Zhang, ... Proceedings of the National Academy of Sciences 118 (10), e2020401118, 2021 | 258 | 2021 |
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression JT Haas, J Miao, D Chanda, Y Wang, E Zhao, ME Haas, M Hirschey, ... Cell metabolism 15 (6), 873-884, 2012 | 222 | 2012 |
Association of habitual alcohol intake with risk of cardiovascular disease KJ Biddinger, CA Emdin, ME Haas, M Wang, G Hindy, PT Ellinor, ... JAMA network open 5 (3), e223849-e223849, 2022 | 216 | 2022 |
The regulation of ApoB metabolism by insulin ME Haas, AD Attie, SB Biddinger Trends in Endocrinology & Metabolism 24 (8), 391-397, 2013 | 184 | 2013 |
Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease D Klarin, E Busenkell, R Judy, J Lynch, M Levin, J Haessler, K Aragam, ... Nature genetics 51 (11), 1574-1579, 2019 | 183 | 2019 |
Phenotypic refinement of heart failure in a national biobank facilitates genetic discovery KG Aragam, M Chaffin, RT Levinson, G McDermott, SH Choi, ... Circulation 139 (4), 489-501, 2019 | 139 | 2019 |
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease CA Emdin, ME Haas, AV Khera, K Aragam, M Chaffin, D Klarin, G Hindy, ... PLoS genetics 16 (4), e1008629, 2020 | 137 | 2020 |
The role of proprotein convertase subtilisin/kexin type 9 in nephrotic syndrome-associated hypercholesterolemia ME Haas, AE Levenson, X Sun, WH Liao, JM Rutkowski, ... Circulation 134 (1), 61-72, 2016 | 114 | 2016 |
Phenotypic consequences of a genetic predisposition to enhanced nitric oxide signaling CA Emdin, AV Khera, D Klarin, P Natarajan, SM Zekavat, A Nomura, ... Circulation 137 (3), 222-232, 2018 | 112 | 2018 |
Genetic association of albuminuria with cardiometabolic disease and blood pressure ME Haas, KG Aragam, CA Emdin, AG Bick, G Hemani, GD Smith, ... The American Journal of Human Genetics 103 (4), 461-473, 2018 | 106 | 2018 |
Role of insulin in the regulation of proprotein convertase subtilisin/kexin type 9 J Miao, PV Manthena, ME Haas, AV Ling, DJ Shin, MJ Graham, ... Arteriosclerosis, thrombosis, and vascular biology 35 (7), 1589-1596, 2015 | 101 | 2015 |
Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene–environment interaction study CA Emdin, M Haas, V Ajmera, TG Simon, J Homburger, C Neben, L Jiang, ... Gastroenterology 160 (5), 1620-1633. e13, 2021 | 94 | 2021 |
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation M Vujkovic, S Ramdas, KM Lorenz, X Guo, R Darlay, HJ Cordell, J He, ... Nature Genetics 54 (6), 761-771, 2022 | 93 | 2022 |
Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease N Ghodsian, E Abner, CA Emdin, E Gobeil, N Taba, ME Haas, N Perrot, ... Cell Reports Medicine 2 (11), 100437, 2021 | 91 | 2021 |
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease CA Emdin, AV Khera, M Chaffin, D Klarin, P Natarajan, K Aragam, M Haas, ... Nature communications 9 (1), 1613, 2018 | 85 | 2018 |