The MR-Base platform supports systematic causal inference across the human phenome G Hemani, J Zheng, B Elsworth, KH Wade, V Haberland, D Baird, ... elife 7, e34408, 2018 | 4498 | 2018 |
Mendelian randomization: genetic anchors for causal inference in epidemiological studies G Davey Smith, G Hemani Human molecular genetics 23 (R1), R89-R98, 2014 | 2880 | 2014 |
Defining the role of common variation in the genomic and biological architecture of adult human height AR Wood, T Esko, J Yang, S Vedantam, TH Pers, S Gustafsson, AY Chu, ... Nature genetics 46 (11), 1173-1186, 2014 | 2086 | 2014 |
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions DM Howard, MJ Adams, TK Clarke, JD Hafferty, J Gibson, M Shirali, ... Nature neuroscience 22 (3), 343-352, 2019 | 1921 | 2019 |
Orienting the causal relationship between imprecisely measured traits using GWAS summary data G Hemani, K Tilling, G Davey Smith PLoS genetics 13 (11), e1007081, 2017 | 1293 | 2017 |
Evaluating the potential role of pleiotropy in Mendelian randomization studies G Hemani, J Bowden, G Davey Smith Human molecular genetics 27 (R2), R195-R208, 2018 | 946 | 2018 |
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic … J Zheng, AM Erzurumluoglu, BL Elsworth, JP Kemp, L Howe, PC Haycock, ... Bioinformatics 33 (2), 272-279, 2017 | 933 | 2017 |
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index J Yang, A Bakshi, Z Zhu, G Hemani, AAE Vinkhuyzen, SH Lee, ... Nature genetics 47 (10), 1114-1120, 2015 | 861 | 2015 |
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression U Võsa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ... Nature genetics 53 (9), 1300-1310, 2021 | 802 | 2021 |
Collider bias undermines our understanding of COVID-19 disease risk and severity GJ Griffith, TT Morris, MJ Tudball, A Herbert, G Mancano, L Pike, ... Nature communications 11 (1), 1-12, 2020 | 768 | 2020 |
Improved heritability estimation from genome-wide SNPs D Speed, G Hemani, MR Johnson, DJ Balding The American Journal of Human Genetics 91 (6), 1011-1021, 2012 | 719 | 2012 |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes A Xue, Y Wu, Z Zhu, F Zhang, KE Kemper, Z Zheng, L Yengo, ... Nature communications 9 (1), 2941, 2018 | 709 | 2018 |
Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score Q Zhao, J Wang, G Hemani, J Bowden, DS Small | 620 | 2020 |
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences R Karlsson Linnér, P Biroli, E Kong, SFW Meddens, R Wedow, ... Nature genetics 51 (2), 245-257, 2019 | 598 | 2019 |
Systematic identification of genetic influences on methylation across the human life course TR Gaunt, HA Shihab, G Hemani, JL Min, G Woodward, O Lyttleton, ... Genome biology 17, 1-14, 2016 | 583 | 2016 |
Recent developments in Mendelian randomization studies J Zheng, D Baird, MC Borges, J Bowden, G Hemani, P Haycock, ... Current epidemiology reports 4, 330-345, 2017 | 567 | 2017 |
Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique FP Hartwig, NM Davies, G Hemani, G Davey Smith International journal of epidemiology 45 (6), 1717-1726, 2016 | 543 | 2016 |
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis U Võsa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ... BioRxiv, 447367, 2018 | 494 | 2018 |
Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study PC Haycock, S Burgess, A Nounu, J Zheng, GN Okoli, J Bowden, ... JAMA oncology 3 (5), 636-651, 2017 | 494 | 2017 |
The MRC IEU OpenGWAS data infrastructure B Elsworth, M Lyon, T Alexander, Y Liu, P Matthews, J Hallett, P Bates, ... BioRxiv, 2020.08. 10.244293, 2020 | 486 | 2020 |