Machine learning-assisted directed protein evolution with combinatorial libraries Z Wu, SBJ Kan, RD Lewis, BJ Wittmann, FH Arnold Proceedings of the National Academy of Sciences 116 (18), 8852-8858, 2019 | 560 | 2019 |
Informed training set design enables efficient machine learning-assisted directed protein evolution BJ Wittmann, Y Yue, FH Arnold Cell systems 12 (11), 1026-1045. e7, 2021 | 168 | 2021 |
Advances in machine learning for directed evolution BJ Wittmann, KE Johnston, Z Wu, FH Arnold Current opinion in structural biology 69, 11-18, 2021 | 142 | 2021 |
FLIP: Benchmark tasks in fitness landscape inference for proteins C Dallago, J Mou, KE Johnston, BJ Wittmann, N Bhattacharya, S Goldman, ... bioRxiv, 2021.11. 09.467890, 2021 | 109 | 2021 |
Diversity-oriented enzymatic synthesis of cyclopropane building blocks BJ Wittmann, AM Knight, JL Hofstra, SE Reisman, SB Jennifer Kan, ... ACS catalysis 10 (13), 7112-7116, 2020 | 55 | 2020 |
EvSeq: cost-effective amplicon sequencing of every variant in a protein library BJ Wittmann, KE Johnston, PJ Almhjell, FH Arnold ACS Synthetic Biology 11 (3), 1313-1324, 2022 | 39 | 2022 |
Flip: Benchmark tasks in fitness landscape inference for proteins. bioRxiv C Dallago, J Mou, KE Johnston, BJ Wittmann, N Bhattacharya, S Goldman, ... preprint, 2021 | 24 | 2021 |
Transcriptomic analysis illuminates genes involved in chlorophyll synthesis after nitrogen starvation in Acaryochloris sp. CCMEE 5410 A Yoneda, BJ Wittmann, JD King, RE Blankenship, G Dantas Photosynthesis research 129, 171-182, 2016 | 23 | 2016 |
Machine learning-assisted directed evolution navigates a combinatorial epistatic fitness landscape with minimal screening burden BJ Wittmann, Y Yue, FH Arnold Biorxiv, 2020.12. 04.408955, 2020 | 18 | 2020 |
Machine learning for protein engineering KE Johnston, C Fannjiang, BJ Wittmann, BL Hie, KK Yang, Z Wu Machine Learning in Molecular Sciences, 277-311, 2023 | 11 | 2023 |
Multistate and functional protein design using RoseTTAFold sequence space diffusion SL Lisanza, JM Gershon, SWK Tipps, JN Sims, L Arnoldt, SJ Hendel, ... Nature biotechnology, 1-11, 2024 | 7 | 2024 |
CARE: a Benchmark Suite for the Classification and Retrieval of Enzymes J Yang, A Mora, S Liu, BJ Wittmann, A Anandkumar, FH Arnold, Y Yue arXiv preprint arXiv:2406.15669, 2024 | 5 | 2024 |
Toward AI-Resilient Screening of Nucleic Acid Synthesis Orders: Process, Results, and Recommendations BJ Wittmann, T Alexanian, C Bartling, J Beal, A Clore, J Diggans, ... bioRxiv, 2024.12. 02.626439, 2024 | | 2024 |
Strategies and Tools for Machine Learning-Assisted Protein Engineering BJ Wittmann California Institute of Technology, 2022 | | 2022 |
Oligo Design BJ Wittmann, KE Johnston, PJ Almhjell, FH Arnolda | | |
Machine Learning for Improved Directed Evolution Efficiency and Outcome BJ Wittmann, Z Wu, F Arnold | | |