New trends in the use of aminoglycosides MY Fosso, Y Li, S Garneau-Tsodikova MedChemComm 5 (8), 1075-1091, 2014 | 95 | 2014 |
Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts Y Li, KD Green, BR Johnson, S Garneau-Tsodikova Antimicrobial agents and chemotherapy 59 (7), 4148-4156, 2015 | 61 | 2015 |
Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and bromperidol derivatives in the treatment of various fungal infections SYL Holbrook, A Garzan, EK Dennis, SK Shrestha, S Garneau-Tsodikova European Journal of Medicinal Chemistry 139, 12-21, 2017 | 49 | 2017 |
Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis … A Garzan, MJ Willby, HX Ngo, CS Gajadeera, KD Green, SYL Holbrook, ... ACS infectious diseases 3 (4), 302-309, 2017 | 46 | 2017 |
Evaluation of Aminoglycoside and Carbapenem Resistance in a Collection of Drug-Resistant Pseudomonas aeruginosa Clinical Isolates SYL Holbrook, S Garneau-Tsodikova Microbial drug resistance 24 (7), 1020-1030, 2018 | 43 | 2018 |
Potent 1,2,4-Triazino[5,6b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis HX Ngo, KD Green, CS Gajadeera, MJ Willby, SYL Holbrook, C Hou, ... ACS infectious diseases 4 (6), 1030-1040, 2018 | 24 | 2018 |
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis A Punetha, HX Ngo, SYL Holbrook, KD Green, MJ Willby, SA Bonnett, ... ACS chemical biology 15 (6), 1581-1594, 2020 | 23 | 2020 |
What is medicinal chemistry?–Demystifying a rapidly evolving discipline! SYL Holbrook, S Garneau-Tsodikova MedChemComm 8 (9), 1739-1741, 2017 | 15 | 2017 |
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance A Punetha, KD Green, A Garzan, NT Chandrika, MJ Willby, AH Pang, ... RSC Medicinal Chemistry 12 (11), 1894-1909, 2021 | 12 | 2021 |
Expanding aminoglycoside resistance enzyme regiospecificity by mutation and truncation SYL Holbrook, S Garneau-Tsodikova Biochemistry 55 (40), 5726-5737, 2016 | 12 | 2016 |
Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity AH Pang, KD Green, NT Chandrika, A Garzan, A Punetha, SYL Holbrook, ... European journal of medicinal chemistry 242, 114698, 2022 | 10 | 2022 |
Emerging targets in anti-tubercular drug design KD Green, SYL Holbrook, HX Ngo, S Garneau-Tsodikova | 2 | 2017 |
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobact A Punetha, KD Green, A Garzan, NT Chandrika, MJ Willby, AH Pang, ... RSC Med. Chem. 11 (12)), 2021 | 1 | 2021 |
Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3′-O-phosphotransferase type IIa SYL Holbrook, MS Gentry, OV Tsodikov, S Garneau-Tsodikova MedChemComm 9 (8), 1332-1339, 2018 | 1 | 2018 |
Antifungal Compositions S Garneau-Tsodikova, A Garzan, SYL Holbrook, EK Dennis US Patent App. 16/038,171, 2019 | | 2019 |
Discovery of New Antimicrobial Options and Evaluation of Aminoglycoside Resistance Enzyme-associated Resistance Epidemic SYL Holbrook | | 2018 |
Supporting Information Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'-O-phosphotransferase type IIa SYL Holbrook, MS Gentry, OV Tsodikov, S Garneau-Tsodikovaa | | |
Broadening the field of opportunity for medicinal chemists rsc. li/medchemcomm SYL Holbrook, S Garneau-Tsodikova | | |