Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions KP Cole, JMC Groh, MD Johnson, CL Burcham, BM Campbell, ... Science 356 (6343), 1144-1150, 2017 | 269 | 2017 |
Continuous manufacturing in pharmaceutical process development and manufacturing CL Burcham, AJ Florence, MD Johnson Annual review of chemical and biomolecular engineering 9 (1), 253-281, 2018 | 146 | 2018 |
Regions of attainable particle sizes in continuous and batch crystallization processes T Vetter, CL Burcham, MF Doherty Chemical Engineering Science 106, 167-180, 2014 | 131 | 2014 |
Formulation and analytical development for low-dose oral drug products J Zheng John Wiley & Sons, 2009 | 112 | 2009 |
The electrohydrodynamic stability of a liquid bridge: microgravity experiments on a bridge suspended in a dielectric gas CL Burcham, DA Saville Journal of Fluid Mechanics 405, 37-56, 2000 | 76 | 2000 |
Process intensification through continuous spherical crystallization using an oscillatory flow baffled crystallizer R Peña, JA Oliva, CL Burcham, DJ Jarmer, ZK Nagy Crystal Growth & Design 17 (9), 4776-4784, 2017 | 68 | 2017 |
Electrohydrodynamic stability: Taylor–Melcher theory for a liquid bridge suspended in a dielectric gas CL Burcham, DA Saville Journal of Fluid Mechanics 452, 163-187, 2002 | 64 | 2002 |
Pilot-scale continuous production of LY2886721: amide formation and reactive crystallization CS Polster, KP Cole, CL Burcham, BM Campbell, AL Frederick, ... Organic Process Research & Development 18 (11), 1295-1309, 2014 | 53 | 2014 |
Particle engineering: a strategy for establishing drug substance physical property specifications during small molecule development RG Iacocca, CL Burcham, LR Hilden Journal of pharmaceutical sciences 99 (1), 51-75, 2010 | 51 | 2010 |
Modeling and optimization of spherical agglomeration in suspension through a coupled population balance model R Peña, CL Burcham, DJ Jarmer, D Ramkrishna, ZK Nagy Chemical Engineering Science 167, 66-77, 2017 | 50 | 2017 |
Separation of conglomerate forming enantiomers using a novel continuous preferential crystallization process T Vetter, CL Burcham, MF Doherty AIChE Journal 61 (9), 2810-2823, 2015 | 48 | 2015 |
Further understanding of agglomeration mechanisms in spherical crystallization systems: benzoic acid case study R Peña, DJ Jarmer, CL Burcham, ZK Nagy Crystal Growth & Design 19 (3), 1668-1679, 2019 | 40 | 2019 |
Designing robust crystallization processes in the presence of parameter uncertainty using attainable regions T Vetter, CL Burcham, MF Doherty Industrial & Engineering Chemistry Research 54 (42), 10350-10363, 2015 | 34 | 2015 |
Quantitative measurements of internal circulation in droplets using flow tagging velocimetry SR Harris, WR Lempert, L Hersh, CL Burcham, DA Saville, RB Miles, ... AIAA journal 34 (3), 449-454, 1996 | 28 | 1996 |
A mechanistic model to predict droplet drying history and particle shell formation in multicomponent systems H Abdullahi, CL Burcham, T Vetter Chemical Engineering Science 224, 115713, 2020 | 27 | 2020 |
A continuous multi-stage mixed-suspension mixed-product-removal crystallization system with fines dissolution D Acevedo, DJ Jarmer, CL Burcham, CS Polster, ZK Nagy Chemical Engineering Research and Design 135, 112-120, 2018 | 27 | 2018 |
API continuous cooling and antisolvent crystallization for kinetic impurity rejection in cGMP manufacturing MD Johnson, CL Burcham, SA May, JR Calvin, J McClary Groh, SS Myers, ... Organic Process Research & Development 25 (6), 1284-1351, 2021 | 24 | 2021 |
Chapter 7; Using quality by design principles as a guide for designing a process control strategy CL Burcham, M LaPack, JR Martinelli, N McCracken Comprehensive Quality by Design for Pharmaceutical Product Development and …, 2017 | 21* | 2017 |
Iterative model‐based experimental design for spherical agglomeration processes K Pal, B Szilagyi, CL Burcham, DJ Jarmer, ZK Nagy AIChE Journal 67 (5), e17178, 2021 | 13 | 2021 |
Characterizing the impact of spray dried particle morphology on tablet dissolution using quantitative X-ray microscopy S Zhang, PA Stroud, A Zhu, MJ Johnson, J Lomeo, CL Burcham, J Hinds, ... European Journal of Pharmaceutical Sciences 165, 105921, 2021 | 12 | 2021 |