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Robert J Watson
Robert J Watson
在 gsk.com 的电子邮件经过验证
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引用次数
引用次数
年份
An improved procedure for the preparation of the Garner aldehyde and its use for the synthesis of N-protected 1-halo-2-(R)-amino-3-butenes
A McKillop, RJK Taylor, RJ Watson, N Lewis
SYNTHESIS-STUTTGART, 31-33, 1994
1611994
CXCR3 antagonist NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor–deficient mice
EJA Van Wanrooij, SCA de Jager, T van Es, P de Vos, HL Birch, DA Owen, ...
Arteriosclerosis, thrombosis, and vascular biology 28 (2), 251-257, 2008
1342008
1, 3-Dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain
EH Demont, P Bamborough, C Chung, PD Craggs, D Fallon, LJ Gordon, ...
ACS medicinal chemistry letters 5 (11), 1190-1195, 2014
992014
Structure-based optimization of naphthyridones into potent ATAD2 bromodomain inhibitors
P Bamborough, C Chung, RC Furze, P Grandi, AM Michon, RJ Sheppard, ...
Journal of Medicinal Chemistry 58 (15), 6151-6178, 2015
982015
Fragment-based discovery of low-micromolar ATAD2 bromodomain inhibitors
EH Demont, C Chung, RC Furze, P Grandi, AM Michon, C Wellaway, ...
Journal of medicinal chemistry 58 (14), 5649-5673, 2015
962015
An enantioselective synthesis of sulphonamide hydroxamic acids as matrix metalloproteinase inhibitors
RJ Watson, D Batty, AD Baxter, DR Hannah, DA Owen, JG Montana
Tetrahedron Letters 43 (4), 683-685, 2002
922002
A chemical probe for the ATAD2 bromodomain
P Bamborough, C Chung, EH Demont, RC Furze, AJ Bannister, KH Che, ...
Angewandte Chemie 128 (38), 11554-11558, 2016
832016
A simple and efficient procedure for the preparation of p-quinols by hypervalent iodine oxidation of phenols and phenol tripropylsilyl ethers
A McKillop, L McLaren, RJK Taylor
Journal of the Chemical Society, Perkin Transactions 1, 2047-2048, 1994
791994
Copper-catalyzed rearrangement of oximes into primary amides
SK Sharma, SD Bishopp, CL Allen, R Lawrence, MJ Bamford, AA Lapkin, ...
Tetrahedron letters 52 (33), 4252-4255, 2011
782011
Iridium-catalyzed formylation of amines with paraformaldehyde
O Saidi, MJ Bamford, AJ Blacker, J Lynch, SP Marsden, P Plucinski, ...
Tetrahedron Letters 51 (44), 5804-5806, 2010
782010
A simple and efficient procedure for the preparation of chiral 2-oxazolidinones from α-amino acids
N Lewis, A McKillop, RJK Taylor, RJ Watson
Synthetic communications 25 (4), 561-568, 1995
761995
GSK789: a selective inhibitor of the first bromodomains (BD1) of the bromo and extra terminal domain (BET) proteins
RJ Watson, P Bamborough, H Barnett, C Chung, R Davis, L Gordon, ...
Journal of Medicinal Chemistry 63 (17), 9045-9069, 2020
682020
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor
J Liddle, FL Atkinson, MD Barker, PS Carter, NR Curtis, RP Davis, ...
Bioorganic & medicinal chemistry letters 21 (20), 6188-6194, 2011
652011
GSK6853, a chemical probe for inhibition of the BRPF1 bromodomain
P Bamborough, HA Barnett, I Becher, MJ Bird, C Chung, PD Craggs, ...
ACS medicinal chemistry letters 7 (6), 552-557, 2016
622016
Synthesis and structure–activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors
MJ Barnes, N Cooper, RJ Davenport, HJ Dyke, FP Galleway, FCA Galvin, ...
Bioorganic & medicinal chemistry letters 11 (8), 1081-1083, 2001
602001
Pt/C catalysed direct reductive amination of nitriles with primary amines in a continuous flow multichannel microreactor
SK Sharma, J Lynch, AM Sobolewska, P Plucinski, RJ Watson, ...
Catalysis Science & Technology 3 (1), 85-88, 2013
57*2013
Discovery of a bromodomain and extraterminal inhibitor with a low predicted human dose through synergistic use of encoded library technology and fragment screening
CR Wellaway, D Amans, P Bamborough, H Barnett, RA Bit, JA Brown, ...
Journal of Medicinal Chemistry 63 (2), 714-746, 2020
522020
Identification and structure–activity relationships of 1-aryl-3-piperidin-4-yl-urea derivatives as CXCR3 receptor antagonists
DR Allen, A Bolt, GA Chapman, RL Knight, JWG Meissner, DA Owen, ...
Bioorganic & medicinal chemistry letters 17 (3), 697-701, 2007
472007
The optimization of a novel, weak bromo and extra terminal domain (BET) bromodomain fragment ligand to a potent and selective second bromodomain (BD2) inhibitor
JT Seal, SJ Atkinson, H Aylott, P Bamborough, C Chung, RCB Copley, ...
Journal of Medicinal Chemistry 63 (17), 9093-9126, 2020
442020
Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3
ME Hayes, GA Wallace, P Grongsaard, A Bischoff, DM George, W Miao, ...
Bioorganic & medicinal chemistry letters 18 (5), 1573-1576, 2008
442008
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