Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach A Cuadrado, G Manda, A Hassan, MJ Alcaraz, C Barbas, A Daiber, ... Pharmacological reviews 70 (2), 348-383, 2018 | 559 | 2018 |
Network-based in silico drug efficacy screening E Guney, J Menche, M Vidal, AL Barábasi Nature communications 7 (1), 10331, 2016 | 495 | 2016 |
Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare D Cirillo, S Catuara-Solarz, C Morey, E Guney, L Subirats, S Mellino, ... NPJ digital medicine 3 (1), 1-11, 2020 | 357 | 2020 |
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen MP Menden, D Wang, MJ Mason, B Szalai, KC Bulusu, Y Guan, T Yu, ... Nature communications 10 (1), 2674, 2019 | 286 | 2019 |
From single drug targets to synergistic network pharmacology in ischemic stroke AI Casas, AA Hassan, SJ Larsen, V Gomez-Rangel, M Elbatreek, ... Proceedings of the National Academy of Sciences 116 (14), 7129-7136, 2019 | 175 | 2019 |
HotSprint: database of computational hot spots in protein interfaces E Guney, N Tuncbag, O Keskin, A Gursoy Nucleic acids research 36 (suppl_1), D662-D666, 2007 | 143 | 2007 |
Exploiting protein-protein interaction networks for genome-wide disease-gene prioritization E Guney, B Oliva Public Library of Science 7 (9), e43557, 2012 | 131 | 2012 |
Architectures and functional coverage of protein–protein interfaces N Tuncbag, A Gursoy, E Guney, R Nussinov, O Keskin Journal of molecular biology 381 (3), 785-802, 2008 | 130 | 2008 |
Tissue specificity of human disease module M Kitsak, A Sharma, J Menche, E Guney, SD Ghiassian, J Loscalzo, ... Scientific reports 6 (1), 35241, 2016 | 106 | 2016 |
Biana: a software framework for compiling biological interactions and analyzing networks J Garcia-Garcia, E Guney, R Aragues, J Planas-Iglesias, B Oliva BMC bioinformatics 11, 1-12, 2010 | 98 | 2010 |
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis SK Sieberts, F Zhu, J García-García, E Stahl, A Pratap, G Pandey, ... Nature communications 7 (1), 12460, 2016 | 92 | 2016 |
Integrating personalized gene expression profiles into predictive disease-associated gene pools J Menche, E Guney, A Sharma, PJ Branigan, MJ Loza, F Baribaud, ... NPJ systems biology and applications 3 (1), 10, 2017 | 64 | 2017 |
A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection F Langhauser, AI Casas, VTV Dao, E Guney, J Menche, E Geuss, ... NPJ systems biology and applications 4 (1), 8, 2018 | 55 | 2018 |
Integrating structure to protein-protein interaction networks that drive metastasis to brain and lung in breast cancer HB Engin, E Guney, O Keskin, B Oliva, A Gursoy PloS one 8 (11), e81035, 2013 | 51 | 2013 |
A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis N Santana-Codina, R Carretero, R Sanz-Pamplona, T Cabrera, E Guney, ... Molecular & Cellular Proteomics 12 (8), 2111-2125, 2013 | 48 | 2013 |
GUILDify: a web server for phenotypic characterization of genes through biological data integration and network-based prioritization algorithms E Guney, J Garcia-Garcia, B Oliva Bioinformatics 30 (12), 1789-1790, 2014 | 46 | 2014 |
iFrag: a protein–protein interface prediction server based on sequence fragments J Garcia-Garcia, V Valls-Comamala, E Guney, D Andreu, FJ Muñoz, ... Journal of molecular biology 429 (3), 382-389, 2017 | 40 | 2017 |
Proximal pathway enrichment analysis for targeting comorbid diseases via network endopharmacology J Aguirre-Plans, J Piñero, J Menche, F Sanz, LI Furlong, HHHW Schmidt, ... Pharmaceuticals 11 (3), 61, 2018 | 39 | 2018 |
FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies A Martínez-Aranda, V Hernández, E Guney, L Muixí, R Foj, N Baixeras, ... Oncotarget 6 (42), 44254, 2015 | 38 | 2015 |
GUILDify v2. 0: A tool to identify molecular networks underlying human diseases, their comorbidities and their druggable targets J Aguirre-Plans, J Piñero, F Sanz, LI Furlong, N Fernandez-Fuentes, ... Journal of molecular biology 431 (13), 2477-2484, 2019 | 36 | 2019 |