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Astrid M Manuel
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Localizing components of shared transethnic genetic architecture of complex traits from GWAS summary data
H Shi, KS Burch, R Johnson, MK Freund, G Kichaev, N Mancuso, ...
The American Journal of Human Genetics 106 (6), 805-817, 2020
572020
TSEA-DB: a trait–tissue association map for human complex traits and diseases
P Jia, Y Dai, R Hu, G Pei, AM Manuel, Z Zhao
Nucleic acids research 48 (D1), D1022-D1030, 2020
262020
Dense module searching for gene networks associated with multiple sclerosis
AM Manuel, Y Dai, LA Freeman, P Jia, Z Zhao
BMC Medical Genomics 13 (5), 1-12, 2020
152020
Predicting regulatory variants using a dense epigenomic mapped CNN model elucidated the molecular basis of trait-tissue associations
G Pei, R Hu, Y Dai, AM Manuel, Z Zhao, P Jia
Nucleic Acids Research 49 (1), 53-66, 2021
132021
CSEA-DB: an omnibus for human complex trait and cell type associations
Y Dai, R Hu, AM Manuel, A Liu, P Jia, Z Zhao
Nucleic Acids Research 49 (D1), D862-D870, 2021
132021
WebCSEA: web-based cell-type-specific enrichment analysis of genes
Y Dai, R Hu, A Liu, KS Cho, AM Manuel, X Li, X Dong, P Jia, Z Zhao
Nucleic acids research 50 (W1), W782-W790, 2022
102022
Distinct effect of prenatal and postnatal brain expression across 20 brain disorders and anthropometric social traits: a systematic study of spatiotemporal modularity
P Jia, AM Manuel, BS Fernandes, Y Dai, Z Zhao
Briefings in bioinformatics 22 (6), bbab214, 2021
72021
An integrative study of genetic variants with brain tissue expression identifies viral etiology and potential drug targets of multiple sclerosis
AM Manuel, Y Dai, LA Freeman, P Jia, Z Zhao
Molecular and Cellular Neuroscience 115, 103656, 2021
62021
Prioritization of risk genes in multiple sclerosis by a refined Bayesian framework followed by tissue-specificity and cell type feature assessment
A Liu, AM Manuel, Y Dai, Z Zhao
BMC genomics 23 (4), 1-17, 2022
32022
Identifying candidate genes and drug targets for Alzheimer’s disease by an integrative network approach using genetic and brain region-specific proteomic data
A Liu, AM Manuel, Y Dai, BS Fernandes, N Enduru, P Jia, Z Zhao
Human Molecular Genetics 31 (19), 3341-3354, 2022
22022
A gene regulatory network approach harmonizes genetic and epigenetic signals and reveals repurposable drug candidates for multiple sclerosis
AM Manuel, Y Dai, P Jia, LA Freeman, Z Zhao
Human Molecular Genetics 32 (6), 998-1009, 2023
12023
Effects of Various Alpha-1 Antitrypsin Supplement Dosages on the Lung Microbiome and Metabolome
T Cickovski, A Manuel, K Mathee, M Campos, G Narasimhan
Computational Advances in Bio and Medical Sciences: 9th International …, 2020
12020
Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations
EV Feofanova, MR Brown, T Alkis, AM Manuel, X Li, UA Tahir, Z Li, ...
Nature Communications 14 (1), 3111, 2023
2023
Enzalutamide-induced signatures revealed by epigenetic plasticity using single-cell multi-omics sequencing in prostate cancer
H Fan, J Li, AM Manuel, Z Zhao
Molecular Therapy-Nucleic Acids 31, 648-661, 2023
2023
Shared genetic components between brain regions identify potential therapeutic targets for Alzheimer’s disease by integrative proteomic analysis
A Liu, AM Manuel, Y Dai, BS Fernandes, N Enduru, P Jia, Z Zhao
Alzheimer's & Dementia 18, e061072, 2022
2022
A single-cell atlas of the human brain in Alzheimer's disease and its implications for personalized drug repositioning
G Pei, BS Fernandes, YY Wang, A Manuel, P Jia, Z Zhao
bioRxiv, 2022.06. 14.496100, 2022
2022
TU22. SPATIOTEMPORAL MODULARITY OF GWAS GENES (STGWAS) IDENTIFIED DISTINCT EFFECT OF PRENATAL AND POSTNATAL BRAIN EXPRESSION ACROSS 20 BRAIN DISORDERS AND ANTHROPOMETRIC SOCIAL …
P Jia, A Manuel, B Fernandes, Y Dai, Z Zhao
European Neuropsychopharmacology 51, e105-e106, 2021
2021
Gene network interpretation of genetic variants and brain tissue expression yields potential drug repositioning strategies for multiple sclerosis
A Manuel, Y Dai, L Freeman, P Jia, Z Zhao
MULTIPLE SCLEROSIS JOURNAL 26 (3_ SUPPL), 366-367, 2020
2020
Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data
K Burch, H Shi, R Johnson, M Freund, G Kichaev, N Mancuso, A Manuel, ...
HUMAN HEREDITY 84 (4-5), 207-207, 2020
2020
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