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Astrid M Manuel
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引用次数
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Localizing components of shared transethnic genetic architecture of complex traits from GWAS summary data
H Shi, KS Burch, R Johnson, MK Freund, G Kichaev, N Mancuso, ...
The American Journal of Human Genetics 106 (6), 805-817, 2020
802020
WebCSEA: web-based cell-type-specific enrichment analysis of genes
Y Dai, R Hu, A Liu, KS Cho, AM Manuel, X Li, X Dong, P Jia, Z Zhao
Nucleic acids research 50 (W1), W782-W790, 2022
412022
TSEA-DB: a trait–tissue association map for human complex traits and diseases
P Jia, Y Dai, R Hu, G Pei, AM Manuel, Z Zhao
Nucleic acids research 48 (D1), D1022-D1030, 2020
312020
CSEA-DB: an omnibus for human complex trait and cell type associations
Y Dai, R Hu, AM Manuel, A Liu, P Jia, Z Zhao
Nucleic Acids Research 49 (D1), D862-D870, 2021
202021
Predicting regulatory variants using a dense epigenomic mapped CNN model elucidated the molecular basis of trait-tissue associations
G Pei, R Hu, Y Dai, AM Manuel, Z Zhao, P Jia
Nucleic acids research 49 (1), 53-66, 2021
182021
Dense module searching for gene networks associated with multiple sclerosis
AM Manuel, Y Dai, LA Freeman, P Jia, Z Zhao
BMC Medical Genomics 13, 1-12, 2020
152020
An integrative study of genetic variants with brain tissue expression identifies viral etiology and potential drug targets of multiple sclerosis
AM Manuel, Y Dai, LA Freeman, P Jia, Z Zhao
Molecular and Cellular Neuroscience 115, 103656, 2021
102021
Identifying candidate genes and drug targets for Alzheimer’s disease by an integrative network approach using genetic and brain region-specific proteomic data
A Liu, AM Manuel, Y Dai, BS Fernandes, N Enduru, P Jia, Z Zhao
Human Molecular Genetics 31 (19), 3341-3354, 2022
82022
Distinct effect of prenatal and postnatal brain expression across 20 brain disorders and anthropometric social traits: a systematic study of spatiotemporal modularity
P Jia, AM Manuel, BS Fernandes, Y Dai, Z Zhao
Briefings in bioinformatics 22 (6), bbab214, 2021
82021
Whole-genome sequencing analysis of human metabolome in multi-ethnic populations
EV Feofanova, MR Brown, T Alkis, AM Manuel, X Li, UA Tahir, Z Li, ...
nature communications 14 (1), 3111, 2023
72023
A gene regulatory network approach harmonizes genetic and epigenetic signals and reveals repurposable drug candidates for multiple sclerosis
AM Manuel, Y Dai, P Jia, LA Freeman, Z Zhao
Human Molecular Genetics 32 (6), 998-1009, 2023
72023
Enzalutamide-induced signatures revealed by epigenetic plasticity using single-cell multi-omics sequencing in prostate cancer
H Fan, J Li, AM Manuel, Z Zhao
Molecular Therapy-Nucleic Acids 31, 648-661, 2023
42023
Prioritization of risk genes in multiple sclerosis by a refined Bayesian framework followed by tissue-specificity and cell type feature assessment
A Liu, AM Manuel, Y Dai, Z Zhao
BMC genomics 23 (Suppl 4), 362, 2022
42022
A single-cell atlas of the human brain in Alzheimer’s disease and its implications for personalized drug repositioning
G Pei, BS Fernandes, YY Wang, AM Manuel, P Jia, Z Zhao
bioRxiv, 2022.06. 14.496100, 2022
22022
Disentangling accelerated cognitive decline from the normal aging process and unraveling its genetic components: A neuroimaging-based deep learning approach
Y Dai, YC Hsu, BS Fernandes, K Zhang, X Li, N Enduru, A Liu, ...
Journal of Alzheimer's Disease, 1-21, 2024
12024
Effects of Various Alpha-1 Antitrypsin Supplement Dosages on the Lung Microbiome and Metabolome
T Cickovski, A Manuel, K Mathee, M Campos, G Narasimhan
Computational Advances in Bio and Medical Sciences: 9th International …, 2020
12020
Montelukast as a repurposable additive drug for standard-efficacy multiple sclerosis treatment: Emulating clinical trials with retrospective administrative health claims data
AM Manuel, A Gottlieb, L Freeman, Z Zhao
Multiple Sclerosis Journal 30 (6), 696-706, 2024
2024
Unveiling Gene Interactions in Alzheimer’s Disease by Integrating Genetic and Epigenetic Data with a Network-Based Approach
KL Sanders, AM Manuel, A Liu, B Leng, X Chen, Z Zhao
Epigenomes 8 (2), 14, 2024
2024
Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease
A Liu, C Citu, N Enduru, X Chen, AM Manuel, T Sinha, DA Gorski, ...
bioRxiv, 2024.06. 25.600720, 2024
2024
Shared genetic components between brain regions identify potential therapeutic targets for Alzheimer’s disease by integrative proteomic analysis
A Liu, AM Manuel, Y Dai, BS Fernandes, N Enduru, P Jia, Z Zhao
Alzheimer's & Dementia 18, e061072, 2022
2022
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