| Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells) F Kazmi, T Hensley, C Pope, RS Funk, GJ Loewen, DB Buckley, ... Drug Metabolism and Disposition 41 (4), 897-905, 2013 | 251 | 2013 |
| Mechanisms of amine accumulation in, and egress from, lysosomes SDB Goldman, RS Funk, RA Rajewski, JP Krise Bioanalysis 1 (8), 1445-1459, 2009 | 120 | 2009 |
| Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: implications for an intracellular distribution-based drug interaction RS Funk, JP Krise Molecular pharmaceutics 9 (5), 1384-1395, 2012 | 119 | 2012 |
| Pediatric pharmacokinetics: human development and drug disposition RS Funk, JT Brown, SM Abdel-Rahman Pediatric Clinics of North America 59 (5), 1001-1016, 2012 | 69 | 2012 |
| Precision pharmacotherapy: integrating pharmacogenomics into clinical pharmacy practice JK Hicks, CL Aquilante, HM Dunnenberger, RS Gammal, RS Funk, ... Journal of the American College of Clinical Pharmacy 2 (3), 303-313, 2019 | 60 | 2019 |
| A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells M Duvvuri, S Konkar, RS Funk, JM Krise, JP Krise Biochemistry 44 (48), 15743-15749, 2005 | 60 | 2005 |
| Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications R Logan, RS Funk, E Axcell, JP Krise Expert opinion on drug metabolism & toxicology 8 (8), 943-958, 2012 | 46 | 2012 |
| Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model RK Singh, L van Haandel, P Kiptoo, ML Becker, TJ Siahaan, RS Funk European journal of pharmacology 853, 264-274, 2019 | 26 | 2019 |
| Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line RS Funk, L van Haandel, ML Becker, JS Leeder Journal of Pharmacology and Experimental Therapeutics 347 (1), 154-163, 2013 | 26 | 2013 |
| Cytokine biomarkers of disease activity and therapeutic response after initiating methotrexate therapy in patients with juvenile idiopathic arthritis RS Funk, MA Chan, ML Becker Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 37 (6 …, 2017 | 19 | 2017 |
| Exposure of cells to hydrogen peroxide can increase the intracellular accumulation of drugs RS Funk, JP Krise Molecular Pharmaceutics 4 (1), 154-159, 2007 | 19 | 2007 |
| Immunogenicity in clinical practice and drug development: when is it significant? V Shakhnovich, B Meibohm, A Rosenberg, AM Kierzek, R Hasenkamp, ... Clinical and translational science 13 (2), 219, 2020 | 18 | 2020 |
| Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate RS Funk, L van Haandel, JS Leeder, ML Becker Arthritis & rheumatology 66 (12), 3476-3485, 2014 | 18 | 2014 |
| Variability in potency among commercial preparations of berberine RS Funk, RK Singh, RD Winefield, SE Kandel, JF Ruisinger, PM Moriarty, ... Journal of dietary supplements 15 (3), 343-351, 2018 | 17 | 2018 |
| Plasma metabolome normalization in rheumatoid arthritis following initiation of methotrexate and the identification of metabolic biomarkers of efficacy MR Medcalf, P Bhadbhade, TR Mikuls, JR O’dell, RL Gundry, RS Funk Metabolites 11 (12), 824, 2021 | 15 | 2021 |
| Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro RS Funk, R Singh, L Pramann, N Gigliotti, S Islam, DP Heruth, SQ Ye, ... Clinical and translational science 9 (3), 149-157, 2016 | 14 | 2016 |
| Altered folate homeostasis in children with down syndrome: a potential basis for enhanced methotrexate toxicity RS Funk, NJ Talib, KO Zimmerman, L van Haandel, ML Becker The Journal of pediatrics 221, 235-239, 2020 | 13 | 2020 |
| Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro RS Funk, RK Singh, ML Becker Clinical and translational science 13 (1), 137-146, 2020 | 13 | 2020 |
| Disease modifying anti-rheumatic drugs in juvenile idiopathic arthritis: striving for individualized therapy RS Funk, ML Becker Expert Review of Precision Medicine and Drug Development 1 (1), 53-68, 2016 | 13 | 2016 |
| Factors associated with reduced infliximab exposure in the treatment of pediatric autoimmune disorders: a cross-sectional prospective convenience sampling study RS Funk, V Shakhnovich, YK Cho, K Polireddy, T Jausurawong, K Gress, ... Pediatric Rheumatology 19 (1), 62, 2021 | 11 | 2021 |
