关注
Anna Wec
Anna Wec
Adagio Therapeutics
在 adagiotx.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Broad neutralization of SARS-related viruses by human monoclonal antibodies
AZ Wec, D Wrapp, AS Herbert, DP Maurer, D Haslwanter, M Sakharkar, ...
Science 369 (6504), 731-736, 2020
5442020
A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus
BM Gunn, WH Yu, MM Karim, JM Brannan, AS Herbert, AZ Wec, ...
Cell host & microbe 24 (2), 221-233. e5, 2018
2212018
Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection
EO Saphire, SL Schendel, ML Fusco, K Gangavarapu, BM Gunn, AZ Wec, ...
Cell 174 (4), 938-952. e13, 2018
1892018
Prolonged evolution of the human B cell response to SARS-CoV-2 infection
M Sakharkar, CG Rappazzo, WF Wieland-Alter, CL Hsieh, D Wrapp, ...
Science immunology 6 (56), eabg6916, 2021
1732021
Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses
AZ Wec, AS Herbert, CD Murin, EK Nyakatura, DM Abelson, JM Fels, ...
Cell 169 (5), 878-890. e15, 2017
1562017
A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses
AZ Wec, EK Nyakatura, AS Herbert, KA Howell, FW Holtsberg, RR Bakken, ...
Science 354 (6310), 350-354, 2016
1282016
Protocadherin-1 is essential for cell entry by New World hantaviruses
RK Jangra, AS Herbert, R Li, LT Jae, LM Kleinfelter, MM Slough, ...
Nature 563 (7732), 559-563, 2018
1112018
Immunization-elicited broadly protective antibody reveals ebolavirus fusion loop as a site of vulnerability
X Zhao, KA Howell, S He, JM Brannan, AZ Wec, E Davidson, HL Turner, ...
Cell 169 (5), 891-904. e15, 2017
1102017
Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection
AZ Wec, ZA Bornholdt, S He, AS Herbert, E Goodwin, AS Wirchnianski, ...
Cell host & microbe 25 (1), 39-48. e5, 2019
1002019
A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates
ZA Bornholdt, AS Herbert, CE Mire, S He, RW Cross, AZ Wec, ...
Cell host & microbe 25 (1), 49-58. e5, 2019
922019
Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine
AZ Wec, D Haslwanter, YN Abdiche, L Shehata, N Pedreño-Lopez, ...
Proceedings of the National Academy of Sciences 117 (12), 6675-6685, 2020
882020
Antibody treatment of Ebola and Sudan virus infection via a uniquely exposed epitope within the glycoprotein receptor-binding site
KA Howell, X Qiu, JM Brannan, C Bryan, E Davidson, FW Holtsberg, ...
Cell reports 15 (7), 1514-1526, 2016
882016
Affinity maturation enhances antibody specificity but compromises conformational stability
L Shehata, DP Maurer, AZ Wec, A Lilov, E Champney, T Sun, ...
Cell reports 28 (13), 3300-3308. e4, 2019
772019
A combination of receptor-binding domain and N-terminal domain neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants
D Haslwanter, ME Dieterle, AZ Wec, CM O’brien, M Sakharkar, C Florez, ...
Mbio 12 (5), 10.1128/mbio. 02473-21, 2021
392021
Structural basis of broad ebolavirus neutralization by a human survivor antibody
BR West, AZ Wec, CL Moyer, ML Fusco, PA Ilinykh, K Huang, ...
Nature structural & molecular biology 26 (3), 204-212, 2019
382019
Generation and characterization of protective antibodies to Marburg virus
JW Froude, T Pelat, S Miethe, SE Zak, AZ Wec, K Chandran, JM Brannan, ...
MAbs 9 (4), 696-703, 2017
282017
Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein
AZ Wec, D Wrapp, AS Herbert, D Maurer, D Haslwanter, M Sakharkar, ...
BioRxiv, 2020
262020
Development of an antibody cocktail for treatment of Sudan virus infection
AS Herbert, JW Froude, RA Ortiz, AI Kuehne, DE Dorosky, RR Bakken, ...
Proceedings of the National Academy of Sciences 117 (7), 3768-3778, 2020
222020
Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses
E Mittler, AZ Wec, J Tynell, P Guardado-Calvo, J Wigren-Byström, ...
Science translational medicine 14 (636), eabl5399, 2022
202022
Viral Hemorrhagic Fever Immunotherapeutic Consortium Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection
EO Saphire, SL Schendel, ML Fusco, K Gangavarapu, BM Gunn, AZ Wec, ...
Cell 174 (4), 938-952, 2018
192018
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