Structural basis for the acyltransferase activity of lecithin: retinol acyltransferase-like proteins M Golczak, PD Kiser, AE Sears, DT Lodowski, WS Blaner, K Palczewski Journal of Biological Chemistry 287 (28), 23790-23807, 2012 | 82 | 2012 |
Towards treatment of Stargardt disease: workshop organized and sponsored by the Foundation Fighting Blindness AE Sears, PS Bernstein, AV Cideciyan, C Hoyng, PC Issa, K Palczewski, ... Translational vision science & technology 6 (5), 6-6, 2017 | 63 | 2017 |
LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3 M Golczak, AE Sears, PD Kiser, K Palczewski Nature chemical biology 11 (1), 26-32, 2015 | 53 | 2015 |
Non-viral gene therapy for Stargardt disease with ECO/pRHO-ABCA4 self-assembled nanoparticles D Sun, RM Schur, AE Sears, SQ Gao, A Vaidya, W Sun, A Maeda, T Kern, ... Molecular Therapy 28 (1), 293-303, 2020 | 40 | 2020 |
Two-photon imaging of the mammalian retina with ultrafast pulsing laser G Palczewska, P Stremplewski, S Suh, N Alexander, D Salom, Z Dong, ... JCI insight 3 (17), 2018 | 32 | 2018 |
An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device L Hofmann, S Gulati, A Sears, PL Stewart, K Palczewski Analytical biochemistry 499, 63-65, 2016 | 30 | 2016 |
Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition CL Sander, AE Sears, AFM Pinto, EH Choi, S Kahremany, F Gao, ... Journal of Cell Biology 220 (8), e202101063, 2021 | 27 | 2021 |
Lecithin: retinol acyltransferase: a key enzyme involved in the retinoid (visual) cycle AE Sears, K Palczewski Biochemistry 55 (22), 3082-3091, 2016 | 27 | 2016 |
Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium D Sun, RM Schur, AE Sears, SQ Gao, W Sun, A Naderi, T Kern, ... ACS applied bio materials 3 (5), 3078-3086, 2020 | 11 | 2020 |
Genome editing in the treatment of ocular diseases EH Choi, S Suh, AE Sears, R Hołubowicz, SR Kedhar, AW Browne, ... Experimental & molecular medicine 55 (8), 1678-1690, 2023 | 7 | 2023 |
Single particle cryo‐EM of the complex between interphotoreceptor retinoid‐binding protein and a monoclonal antibody AE Sears, S Albiez, S Gulati, B Wang, P Kiser, L Kovacik, A Engel, ... The FASEB Journal 34 (10), 13918, 2020 | 5 | 2020 |
Coats plus syndrome in a premature infant, with a focus on management AE Sears, CC Awh, S Kunhiabdullah, JE Sears, DA Mammo Journal of VitreoRetinal Diseases 7 (1), 74-78, 2023 | 1 | 2023 |
Dissecting lipid contents in the distinct regions of native retinal rod disk membranes C Sander, A Sears, AFM Pinto, EH Choi, S Kahremany, HG Jin, E Pardon, ... Investigative Ophthalmology & Visual Science 62 (8), 529-529, 2021 | 1 | 2021 |
Molecular basis for rapid corticosteroid effects: isolation of plasma membrane glucocorticoid receptor from retinal glia G Hoppe, A Sears, JE Sears Investigative Ophthalmology & Visual Science 51 (13), 3725-3725, 2010 | 1 | 2010 |
Triamcinolone Acetonide Induces Synthesis and Secretion of Thrombospondin 1 by Human Müller Cells AE Sears, G Hoppe, JE Sears Investigative Ophthalmology & Visual Science 48 (13), 1730-1730, 2007 | 1 | 2007 |
Cryo-electron microscopy single-particle analysis of interphotoreceptor retinoid-binding protein and the peripherin/ROM1 complex, proteins necessary for the sensation of vision AE Sears Case Western Reserve University, 2021 | | 2021 |
Efficient Non-viral Gene Therapy for Stargardt’s Disease with pH-Sensitive Multifunctional Lipid ECO Plasmid DNA Nanoparticles D Sun, R Schur, A Sears, S Gao, R Xin, A Maeda, K Palczewski, ZR Lu Investigative Ophthalmology & Visual Science 60 (9), 2915-2915, 2019 | | 2019 |
pH-Sensitive Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-Viral Gene Therapy for Stargardt's Disease D Sun, R Schur, A Sears, S Gao, AM Vaidya, R Xin, A Maeda, ... MOLECULAR THERAPY 26 (5), 316-316, 2018 | | 2018 |
Structural and Functional Adaptations in N1pC/P60 Enzymes Facilitate Retinyl Ester Formation M Golczak, AE Sears, PD Kiser, K Palczewski Investigative Ophthalmology & Visual Science 56 (7), 5517-5517, 2015 | | 2015 |