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Avery E. Sears
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Structural basis for the acyltransferase activity of lecithin: retinol acyltransferase-like proteins
M Golczak, PD Kiser, AE Sears, DT Lodowski, WS Blaner, K Palczewski
Journal of Biological Chemistry 287 (28), 23790-23807, 2012
822012
Towards treatment of Stargardt disease: workshop organized and sponsored by the Foundation Fighting Blindness
AE Sears, PS Bernstein, AV Cideciyan, C Hoyng, PC Issa, K Palczewski, ...
Translational vision science & technology 6 (5), 6-6, 2017
632017
LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3
M Golczak, AE Sears, PD Kiser, K Palczewski
Nature chemical biology 11 (1), 26-32, 2015
532015
Non-viral gene therapy for Stargardt disease with ECO/pRHO-ABCA4 self-assembled nanoparticles
D Sun, RM Schur, AE Sears, SQ Gao, A Vaidya, W Sun, A Maeda, T Kern, ...
Molecular Therapy 28 (1), 293-303, 2020
402020
Two-photon imaging of the mammalian retina with ultrafast pulsing laser
G Palczewska, P Stremplewski, S Suh, N Alexander, D Salom, Z Dong, ...
JCI insight 3 (17), 2018
322018
An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device
L Hofmann, S Gulati, A Sears, PL Stewart, K Palczewski
Analytical biochemistry 499, 63-65, 2016
302016
Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition
CL Sander, AE Sears, AFM Pinto, EH Choi, S Kahremany, F Gao, ...
Journal of Cell Biology 220 (8), e202101063, 2021
272021
Lecithin: retinol acyltransferase: a key enzyme involved in the retinoid (visual) cycle
AE Sears, K Palczewski
Biochemistry 55 (22), 3082-3091, 2016
272016
Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium
D Sun, RM Schur, AE Sears, SQ Gao, W Sun, A Naderi, T Kern, ...
ACS applied bio materials 3 (5), 3078-3086, 2020
112020
Genome editing in the treatment of ocular diseases
EH Choi, S Suh, AE Sears, R Hołubowicz, SR Kedhar, AW Browne, ...
Experimental & molecular medicine 55 (8), 1678-1690, 2023
72023
Single particle cryo‐EM of the complex between interphotoreceptor retinoid‐binding protein and a monoclonal antibody
AE Sears, S Albiez, S Gulati, B Wang, P Kiser, L Kovacik, A Engel, ...
The FASEB Journal 34 (10), 13918, 2020
52020
Coats plus syndrome in a premature infant, with a focus on management
AE Sears, CC Awh, S Kunhiabdullah, JE Sears, DA Mammo
Journal of VitreoRetinal Diseases 7 (1), 74-78, 2023
12023
Dissecting lipid contents in the distinct regions of native retinal rod disk membranes
C Sander, A Sears, AFM Pinto, EH Choi, S Kahremany, HG Jin, E Pardon, ...
Investigative Ophthalmology & Visual Science 62 (8), 529-529, 2021
12021
Molecular basis for rapid corticosteroid effects: isolation of plasma membrane glucocorticoid receptor from retinal glia
G Hoppe, A Sears, JE Sears
Investigative Ophthalmology & Visual Science 51 (13), 3725-3725, 2010
12010
Triamcinolone Acetonide Induces Synthesis and Secretion of Thrombospondin 1 by Human Müller Cells
AE Sears, G Hoppe, JE Sears
Investigative Ophthalmology & Visual Science 48 (13), 1730-1730, 2007
12007
Cryo-electron microscopy single-particle analysis of interphotoreceptor retinoid-binding protein and the peripherin/ROM1 complex, proteins necessary for the sensation of vision
AE Sears
Case Western Reserve University, 2021
2021
Efficient Non-viral Gene Therapy for Stargardt’s Disease with pH-Sensitive Multifunctional Lipid ECO Plasmid DNA Nanoparticles
D Sun, R Schur, A Sears, S Gao, R Xin, A Maeda, K Palczewski, ZR Lu
Investigative Ophthalmology & Visual Science 60 (9), 2915-2915, 2019
2019
pH-Sensitive Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-Viral Gene Therapy for Stargardt's Disease
D Sun, R Schur, A Sears, S Gao, AM Vaidya, R Xin, A Maeda, ...
MOLECULAR THERAPY 26 (5), 316-316, 2018
2018
Structural and Functional Adaptations in N1pC/P60 Enzymes Facilitate Retinyl Ester Formation
M Golczak, AE Sears, PD Kiser, K Palczewski
Investigative Ophthalmology & Visual Science 56 (7), 5517-5517, 2015
2015
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